Conserved Protein Domain Family
CYP39A1
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cd20635: CYP39A1 
cytochrome P450 family 39, subfamily A, polypeptide 1
Cytochrome P450 39A1 (CYP39A1) is also called 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) or oxysterol 7-alpha-hydroxylase. It is involved in the metabolism of bile acids and has a preference for 24-hydroxycholesterol, converting it into the 7-alpha-hydroxylated product. It may play a role in the alternative bile acid synthesis pathway in the liver. CYP39A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410728
Aligned: 13 rows
Threshold Bit Score: 659.773
Created: 12-Sep-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #      #     
Q9NYL5        49 PLEFIEKARIKYGPIFTVFamGNRMTFVTeEEGINVFLKSKkvdfeLAVQNIVYRTasipknvFLALHEKLYIMLKGKMG 128 human
NP_001025360  49 PLHFIQQARAKYGPVFTVVaaGKRMTFVTlNEDFRVFFTSKdvdfeQAVQEPVHNTasiskdnFFESHPTCSAIIKGRLT 128 zebrafish
AAI06434      60 PLEFIARAKEKHGPVFTVLaaGNRLTFLNgKEGVSAFFSSKdadfqQAVQKPVQHTasinkadFMKSHSSIHETMKLRLS 139 African clawed ...
XP_006003735  49 PLEFIEDARVKYGPVFTVVaaGNRMTFVTeEEGFNLFFTSKdvdfqEAVQDPVQHTasiskesFYKNHTATHDMLKGRLA 128 coelacanth
KFV41728      31 PLEFIEQARSKHGPVFTIValGKRFTFVTeEEGTEAFFKSKdlnfeQAVQQAVENAvsvpaeaFYQNHSNLYSMMKGKMG 110 Gavia stellata
XP_020849602  49 PLEFIEQARIKHGPVFTVFalGKRLTFVTeEEGFDVFFKSKeinfeHAVEDHIYRTvsvpksiFLTSHGLLYGVMKNKMK 128 koala
XP_021376799  62 PLAFIDKMRQQMGAIYTLYvaGERLTFLTdADDFHHFFQSAnvdfqKAVQDPVQNIasvseesFFQFHTKVHDMVKGRLA 141 Yesso scallop
XP_009046186  43 PLHFINKKSKELGSIFSIKvtGEYMTFVTdPKDFQYFFQSPcldfqKAVQGPVQNVvsitkesFFAYHSSIHDLVKGKLA 122 owl limpet
ELU17287      63 PLNFIQNARQKLGPIFTLKvlGQRLTFVTeEEDIEVFFNNPdldfeLAVHKPVKNAasippepFFSNHFKLHSMMKGYLA 142 Capitella teleta
XP_009060299  64 PLEFIHKKQQDLGPVFTCKiaGENMTFLTdPQDLHAFFQSPcldfqKAVQTSVQNVasiskesFFKYHSNIHDLVKGKLA 143 owl limpet
XP_011456120  58 PLGFIDKKRRELGPVFTLHvaGERLTFLTeAEDFHHFFQSSnvdfqRAVQDPVQNIasvseesFMQYHTKIHDMMKGRLA 137 Pacific oyster
XP_003387846  68 PLYYIKRVHEELGDIFTIYavGKRMTFLLdYKDSSTYFKTPsasfkEAAIDFTTAAasieptsFSEHHTKIHDIFKGQLT 147 Amphimedon quee...
XP_005101364  51 PIDFIEAKRRQLGSVFTLKvaGEHITFVCdPEDFHYVFKSSkvsfpKSVQDPVNKVagitrksFNEIHTKMHDTLKGQLA 130 California sea ...

Feature 1                                                                                        
Q9NYL5       129 tv----nlHQFTGQLTEELHEQLENLGTHGTmdl-----nnLVRHLLYPVTVNMLFNkslfstn-kkkikeFHQYFQVYD 198 human
NP_001025360 129 pg----ntAMLSPHLCEEFNDHLESLGSEGSgql-----neLIKSVMYPSVMSNLLGrcnspss-alsrqeFLEKFTTYD 198 zebrafish
AAI06434     140 qn----rlNLYFDRIRNEFGTRIELLDPEGTedl-----ftLVKQVMYPAVVDTLFGkglcptg-kdnlkeFAEHFWKFD 209 African clawed ...
XP_006003735 129 ps----nlHLFSEGLCQEFTEHLQYLGEKGTeel-----sdLVRHVMYPAVVNNLFGkgicpts-kdaikeFEEHFLKFD 198 coelacanth
KFV41728     111 ps----nlHMFTGTLCEELHEHMAHLGTEGTgdl-----ndLVRHVMYPAVVNTLFGkgicpts-qseikeFEEHFQKYD 180 Gavia stellata
XP_020849602 129 is----nlCQFSEKLVEGLHEQLESLGTDGSkdl-----ynLVRHALYPVTVNTIFGkglyptt-qeniqeFLKHFQIYD 198 koala
XP_021376799 142 ss----rlVYFHDDLCQEFDKEIDEIVSIKGacn----lhqVVRQSMYKAVINNLFGpgvlpttdmtkfknLEKNFVLFD 213 Yesso scallop
XP_009046186 123 ss----qlAPMSDKLYTEFKEQLAKLPESGTidl-----nrLIRSVLYKSVLNILFGknilptd-deqyreLEDNFTKFD 192 owl limpet
ELU17287     143 pa----klEPLCKRLNEKFSWHVKKWGESGSgdl-----ykMVRKAMYAPVVEGLFGddvlptn-ddeyktFEKLFVQFD 212 Capitella teleta
XP_009060299 144 ss----qlAAMSDKLYTEFKEQLDTLPSQGTedl-----nkLVRYLMYKPTLNCLFGrnslpvn-nevnknCFEHFVKFD 213 owl limpet
XP_011456120 138 ss----rlSDVTPHLIQQFKGKIQLVFGDEGegd----lhdLVRKTMYAGVINNLFGdntlpvddpkefekICQHFIVFD 209 Pacific oyster
XP_003387846 148 mh----hlDPLCQELSLSFYHEILLQVREREgqevemelmdFVRKTMFGPVVKQLFGqsnlqls-eeeiksMLTNFIKYD 222 Amphimedon quee...
XP_005101364 131 ttqlsstcDLLFKKFEHFFGQLKENVDPQQEtdl-----ygIVRSIMYRSVIHIFFGegsipvekeedfldFENHFMTFD 205 California sea ...

Feature 1                                                                                   ##  #
Q9NYL5       199 EDFEYGsqlpeclLRNWSKSKKWFLELFEKNIPDIkacks-akdnSMTLLQATLDIVetetsKENSPNYGLLLLWASLSN 277 human
NP_001025360 199 EGFEYGsqlpemfLKEWSNSKHWLLSLLRKMVIKSeetly-sesdRKTLLQHLAASIs----EQYLPNYGLLLLWASLAN 273 zebrafish
AAI06434     210 EGFEYGsqlpeflLRDWSQSKQWLLSLFKKIVIEAemnnp-leetSKTLYQHVLDTLk----GIATYNNSLLLLWASQAN 284 African clawed ...
XP_006003735 199 EDFEYGsqlpeifLTNWSKSKQWLLSVLEKVVENAertkp-sdnnSKTLLQHLLETLn----GNGAPNYCLLMLWASQAN 273 coelacanth
KFV41728     181 EDFEYAsqmpecfLRNWSKSKKWLLKLFEKVVSDAertnp-setaSKTLLQHLLDNLq---gKHLAPNYGLLMLWASQAN 256 Gavia stellata
XP_020849602 199 DGFQNGgqipecfLRNWSKSKMWLLNLLEKSIPDLekne---tldDLTVMQLIANTLrprakQDKVPNYAVLMLWASLSN 275 koala
XP_021376799 214 ELFEYGarlpsfmIRDWTSSKWQLVGMFKDLYKGIknkk---rteNETVLQTLLNLVd----DKHAPNYALLFLWASLAN 286 Yesso scallop
XP_009046186 193 EQFEYGsklpaflLGGWSQSRQYLIDMFKNLVDSEkkksqdlpvsEKTLLHNVLECVd----KENSPNYSVLLLWATLAN 268 owl limpet
ELU17287     213 DNFEYAaqippffLKDFNSAKTWLMDKFVTATKIAekak--lnngAETLFQTLIKTVd----HEWAPNFGLLMMWASLAN 286 Capitella teleta
XP_009060299 214 DQFEYGaklpaflLKAWSSSREYLLKIFCSLVNDKkessh-qtnnDKTLFESLLDTId----DQSSPNFCLLLMWASLAN 288 owl limpet
XP_011456120 210 EQFEYGarlppmfIRDWSTAKQYLLSKFRGVVPKLqnek---tqgNQTVLQSLVSITd----KPHAPNYALMLLWAALAN 282 Pacific oyster
XP_003387846 223 ADFKYAqlp-aifNREWGSTKEYLLNIMKKVVGRVpkq----adcLKHAAEHIISAVd----PANAPGYSLMVLWASQAN 293 Amphimedon quee...
XP_005101364 206 EQFEYGtrlpvifIRKWAASRQWLLEKCERVVSLCtktmp-kepkDKNIFQNLLPLId----EDNKANWSLLTLWAALAN 280 California sea ...

Feature 1        #  #                                                                # #         
Q9NYL5       278 AVPVAFWTLAYVLSHPDIHKAIMEGISSvfgkagkd----kikvsedDLENLLLIKWCVLETIRLKAPGVITRKVVKPVE 353 human
NP_001025360 274 AIPVTFWAVAFILSNPTAYKIVMDQINSvlgrqdkq----ktkvtldDLQQMPYVKWCIMEAIRLRAPGAITRKVVRPLK 349 zebrafish
AAI06434     285 ANPVTFWTLAFIISDPLVYKTAMDEIYSvfgktgns----plnineaELKRLPFIKNCVLEAIRLRSPGAITRKAVQPLK 360 African clawed ...
XP_006003735 274 AVPVTFWSLAFIVSHPSVYKTAMDKISSvfgkkgkd----svkvsetHLHQLCYIKWCILEAIRLCSPGAIARKVIRPLK 349 coelacanth
KFV41728     257 AVPIAFWTLVFILSYPSIYKKIMEDLASvfgkagkd----kievseeDLKKLPFIKWCTLEAIRLRSPGAITKKVVNPIR 332 Gavia stellata
XP_020849602 276 ATPVAYWTIVYVLYNPSVYENIMEGISSvfgeagkk----kieisenDLKKVPLIKRCVLETIRLVAPGMITRKVIEPVK 351 koala
XP_021376799 287 AVPITFWCLVFILSDQTVLSKLKRELVStlgtlekg----kvriteeQIKEMPYLRWCVLEAIRLRPVGIITRRVIKAFK 362 Yesso scallop
XP_009046186 269 SIPMIFWTMAFIVTRQSVYEKVCNEIEEklpekl-------etiteaDLRKMPYLKSCILETVRLRSPGIIPRYVAKPFK 341 owl limpet
ELU17287     287 AIPITFWVLAFILENPDVLAEVRKELRRelkgllfcwfisfakisleKLQNLELIKRCILESIRLRSPGAISRGVEKEIK 366 Capitella teleta
XP_009060299 289 AIPMTFWTLAYILTHEDVYKKVCDEINNtipdnily----ilivfniDINKMVYIKSCILETIRLRSPGVIPRYVVQPFQ 364 owl limpet
XP_011456120 283 AVPITFWALSMILSNKRVLEKLQKQVDDtlgntpee----kwefnedFFKKMPYLKSCVMEAIRLHSVGVITRRVMTSFT 358 Pacific oyster
XP_003387846 294 AIPISFWTLSFILSHPNVYKKIKEELKEwplfqkdet-sfnavkeedLKAAPPTIKRAILEAIRLRSPGMIARKVTEPIK 372 Amphimedon quee...
XP_005101364 281 AIPLSFWVLTFVYQDKKVLGKVQREIDAalkdgr--------pitesVLSEMPYTLRCVMEGIRLRSPGMIPRRVVEPIV 352 California sea ...

Feature 1                                                            ###   # ###  ##             
Q9NYL5       354 ILNYIIPSGDLLMLSPFWLHrNPKYFPEPELFKPERWkkanlekhsfldcFMAFGSGKFQCPARWFALLEVQMCIILILY 433 human
NP_001025360 350 LQNYVIPPGDMLMLSPYWAHrNPKYFPDPEDFKPERWetadleknvllegFVAFGGGKNQCPGRWYAIMELHMFVALILY 429 zebrafish
AAI06434     361 IYNYIIPAGDLLMLSPYWLHrDPVLFPEPEMFRPERWskanleknvflegFVAFGGGKYQCPGRWFALMEMHMLVVMMLY 440 African clawed ...
XP_006003735 350 VQNYIIPPGDMLMMSPFWAHrNPKYFPEPEQFIPERWrkadleknvfldgFVAFGGGRYQCPGRWFALMEIHMLVIMMLY 429 coelacanth
KFV41728     333 IQNFTIPAGDMLMLSPYWLHrNPKYFPDPEMFKPDRWkeanleknafldsFVAFGGGKHQCPGRWFAIMEIQLFVVLLLY 412 Gavia stellata
XP_020849602 352 ILNYTVPSGDMLMMSPFWIHrNPKYFPEPELFKPERWekanleknafldgFVAFGGGKYPCPGRWFALLEIEICVALVFY 431 koala
XP_021376799 363 VKEMVIPEGDMLMLSPYWAHrNPKYFTASEEFRPDRWkdadleknlfldgFVAFGGGRYQCPGRWYAQMEIQMYVALFLH 442 Yesso scallop
XP_009046186 342 IRDLTVPAGNLIFASPFWAHrNPEHYPDPEEHKPERWnmkdvernifpeyFFAFGGGRFQCPGRWFGLMEIQIFVIMFLK 421 owl limpet
ELU17287     367 IKDFTIPEGDMLMLSPYWMHrNPKFFPDPEAFKPDRWlqadvkrniflkgFMPFGGGRFQCPGRWFALMEIQLFVAIVLK 446 Capitella teleta
XP_009060299 365 IGKYTVPVGHRIFASVFWAHrNPDCFQDPNRFNPERWdtkdiernvfpkyFFPFGGGRYQCPGRWFGLMEIQIFLVMFLK 444 owl limpet
XP_011456120 359 MREYVIPKGDMLMVSPFWSHrNPKYFPEPDTFNPDRWntsdleknlylegFIAFGGGRYQCPGRWYALMELQMFIALFLF 438 Pacific oyster
XP_003387846 373 IKEYTVPAGHYLMMSPYHSHrNQTYFPDPETFNPERWlecdidknqflpgFIAFGGGRYQCPGRWFALMELHLYISMILK 452 Amphimedon quee...
XP_005101364 353 VKGYTVPPGHMLSVSPYWVNrNPDIYEDPELFNPDRWsdwtpg--sipetFIPFGGGRYMCPGRWFALMEIHMFVAMFFH 430 California sea ...

Feature 1                             #        
Q9NYL5       434 KYDc-sLLDPLPKQSylHLVGVPQPEGQCR 462 human
NP_001025360 430 KFEf-aQLDPMPKPSplHLVGTQQPDGPCT 458 zebrafish
AAI06434     441 KYEf-sLLDPLPKQSnlHLVGTQQPDGPCR 469 African clawed frog
XP_006003735 430 SYEf-tLLDPLPKQSplHLVGTQQPVGPCR 458 coelacanth
KFV41728     413 KYEf-vLLDAVPKESplHLVGTQQPMAPCR 441 Gavia stellata
XP_020849602 432 KYQf-nLLDPFPKQNfnQLLGVQRPSTPCR 460 koala
XP_021376799 443 KVDctvLSDHVPSPStkHLVGTQQPAEPFL 472 Yesso scallop
XP_009046186 422 QFTc-eAFDPVPQPSpfHIVGTQQPLGPCM 450 owl limpet
ELU17287     447 SVDi-dLLEKVPDNSllHLLGVQQPETGLM 475 Capitella teleta
XP_009060299 445 KFKf-eVFDSLPKPSylHIVGTQQPATSFS 473 owl limpet
XP_011456120 439 KYKvnaLSDHVPSPSlkHVVGTQQPSKPFL 468 Pacific oyster
XP_003387846 453 LLDm-tLIDEVPKPSplHLTGSQQPEGSCF 481 Amphimedon queenslandica
XP_005101364 431 TFDc-hLTKGIPDFCklHLVGSQQPLQNCP 459 California sea hare

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