1PRZ,1V9K,1V9K


Conserved Protein Domain Family
PseudoU_synth_RluA_like

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cd02869: PseudoU_synth_RluA_like 
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Pseudouridine synthase, RluA family.
This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and TruA. Pseudouridine synthases catalyze the isomerization of specific uridines in a n RNA molecule to pseudouridines (5-ribosyluracil, psi) requiring no cofactors. E. coli RluC for example makes psi955, 2504 and 2580 in 23S RNA. Some psi sites such as psi1917 in 23S RNA made by RluD are universally conserved. Other psi sites occur in a more restricted fashion, for example psi2819 in 21S mitochondrial ribosomal RNA made by S. cerevisiae Pus5p is only found in mitochondrial large subunit rRNAs from some other species and in gram negative bacteria. The E. coli counterpart of this psi residue is psi2580 in 23S rRNA. psi2604in 23S RNA made by RluF has only been detected in E.coli.
Statistics
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PSSM-Id: 211346
Aligned: 264 rows
Threshold Bit Score: 90.4744
Created: 1-Aug-2005
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1prz_a, active site residues for catalytic function
  • Structure:1prz_a, active site residues based on reference

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
1PRZ_A        19 IIVINKPrDLVVhpgagnpdgtvlnal----------------------------------------------------- 45   Escherichia coli
Q12362       170 ILVIDKPsSIPVhptgryrfntitk------------------------------------------------------- 194  baker's yeast
EAL51350      64 RRVLPYFyTFKVnakgrwigrtiv-------------------------------------------------------- 87   Entamoeba hist...
CAC22676    1209 ALVQRWPpFSSSssssastvryd--------------------------------------------------------- 1231 Leishmania major
ZP_00307802   17 YFFINKPpFISSldertggapsii-------------------------------------------------------- 40   Cytophaga hutc...
CAF23430      84 ILYEDEDlFIYDkpaemncdeqgii------------------------------------------------------- 108  Parachlamydia ...
CAJ05143     449 VPAVHAPsSTPAsppaslqrvlasryelqk-------------------------------------------------- 478  Leishmania major
EAN89094     429 WLRVDRLiGCLSyhkslywcpdaalt------------------------------------------------------ 454  Trypanosoma cruzi
CAF89720      20 YVVVDKHwDLRIdskmwyekltvq-------------------------------------------------------- 43   Tetraodon nigr...
CAJ06253      92 YYVALLHgHLPSdtalledaassdqpgsafssdtkarrasfaawanacnkaweglgcvragcsasasggssansaggdev 171  Leishmania major
Feature 1                                              ####                                      
1PRZ_A        46 ----------------------lhyyppiadvpragiVHRLDKDTTGLXVVAktVPAQTRLvesl------------qrr 91   Escherichia coli
Q12362       195 -------------------------mlerqlgysvhpCNRLDKPTSGLMFLAktPLGADRMgdqm------------kar 237  baker's yeast
EAL51350      88 -------------------------dvfvhefklcneETTIKKIEKGLIKINnkIIEPSTIihhhdeiehq-vhrheppv 141  Entamoeba hist...
CAC22676    1232 --------------------------ddnaaaaplfsVSPFLSPMPSAVVCApvYAAGATAssisrrsalplshgrqlqs 1285 Leishmania major
ZP_00307802   41 -------------------------rmakeywpdaqlCHRIDKETSGVLAVAknPAAYRHLsmaf------------esr 83   Cytophaga hutc...
CAF23430     109 -------------------------allrpsfpsiqlIHRLDRQTTGVLALAknKTTFEALvnqf------------kql 151  Parachlamydia ...
CAJ05143     479 --------------------yylarvrvestrvlpgsGTTFEAEAQRQHTPQpsPLTSPSLplalppplr--vwrvagde 536  Leishmania major
EAN89094     455 ------------------------eswlnekekwekdAKEQQQSASMVKGHAagRKRGAPFgdaa------------ale 498  Trypanosoma cruzi
CAF89720      44 --------------------------aqlqasfppagRPQHLLRFQVLSPVGf-LDKWSSLccp--------------qq 82   Tetraodon nigr...
CAJ06253     172 agfrhllqrpdktaweavglanskdaeegepvtvvhrYRSHRSPASSLITVAp-ENSAPVPadav-------------ed 237  Leishmania major
Feature 1                                                                                        
1PRZ_A        92 eITREYEAVAIGhxtaggtvdepisrh-------------------------------------------ptkrthxavh 128  Escherichia coli
Q12362       238 eVTKEYVARVKGefpigivevdkpvrsvnp--------------------------------------kvalnavcemsd 279  baker's yeast
EAL51350     142 yCDKLTIVKETNdfiaidkpssipvhpkigrk---------------------------------riddkkihvsvneie 188  Entamoeba hist...
CAC22676    1286 pGQPSADALAASragstlswsssvpvslssl-----------------------------------ehvhqqyatlhaal 1330 Leishmania major
ZP_00307802   84 nVTKEYHAVVNGthdldgvdvylpilv-------------------------------------------lptgtvkidk 120  Cytophaga hutc...
CAF23430     152 kVSKSYRAIVDGiltsskghienylgkkhv--------------------------------------yqgqsiwgevps 193  Parachlamydia ...
CAJ05143     537 pCLRTHNAYVSRmlssangvcdvaslrarqptkcssalpgvfpdgvlttvpvpasgalasspaaaatlcqllfalptitn 616  Leishmania major
EAN89094     499 aKHERMRQLTRGgrakataasdgevnndsrh-----------------------------------pvestskiqmqrlk 543  Trypanosoma cruzi
CAF89720      83 sCCWPGVPLLQGphrhqslpr--------------------------------------------------------lsc 106  Tetraodon nigr...
CAJ06253     238 lIYRTLLESTTTcsvvfvdlp--------------------------------------------------------vgy 261  Leishmania major
Feature 1                                                                                   #    
1PRZ_A       129 pxgkpAVTHYRIXEhfr-----------------------------------------vhtRLRLRLETGRTHQIRVHXA 167  Escherichia coli
Q12362       280 enakhAKTVFQRVSydg-----------------------------------------qtsIVKCKPLTGRTHQIRVHLQ 318  baker's yeast
EAL51350     189 edgkeCHSEFNPLFydek---------------------------------------tnttVAVALLGSGRTHQIRVHLQ 229  Entamoeba hist...
CAC22676    1331 qdqrnAITRYRVLEyfas---------------------------------------agvaYVQVELCSGRRHQIRQHFA 1371 Leishmania major
ZP_00307802  121 skgklAETIFFTIQayk-----------------------------------------katLVRCLPITGRMHQIRIHLA 159  Cytophaga hutc...
CAF23430     194 fqglyASTYWSCLEigk-----------------------------------------kasLVRCFPKTGRTHQIRVHLA 232  Parachlamydia ...
CAJ05143     617 aarqdGVQHAETSAagvs----------------------------------------eeaVVLCTPYTGRLHQIRMHLS 656  Leishmania major
EAN89094     544 esmkqAITLIRLLAydaa---------------------------------------cdesVVECLLLTGRTHQVRVHLA 584  Trypanosoma cruzi
CAF89720     107 ekpktCRSELAVLEyglyd-------------------------------------gepvtKALLQPLTGRTHQLRVHCS 149  Tetraodon nigr...
CAJ06253     262 dltdpEHLRMAVTAeqsrdaktsllvlkrtylaapppaggevpqrgaiakdspsvtsypvtLVLLAPHTGRRHQLRVHCR 341  Leishmania major
Feature 1                                                                                        
1PRZ_A       168 HITHplvGDPVYGgrprppkgasea----------------------------------------------fistlrkfd 201  Escherichia coli
Q12362       319 YLGFpiaNDPIYSnpdiwgpdlgrgglqnyddivlkldaigktnpaeswihphsegeyllgrqceeceaemytdpgtndl 398  baker's yeast
EAL51350     230 SIHHpivNDPIYAaqfdeskcddegifetqyggtiq------------------------wkieegciecehlkgdpiqy 285  Entamoeba hist...
CAC22676    1372 QLGFplvGDARYHagvvaghag----------------------------------------------------ttlgmr 1399 Leishmania major
ZP_00307802  160 TLGAsivGDETYGgkp---------------------------------------------------------------- 175  Cytophaga hutc...
CAF23430     233 GLGHpilGDYQYGkkftcly---------------------------------------------------------npp 255  Parachlamydia ...
CAJ05143     657 SLGCpivGDVVYAptsgsadvpgtp----------------------------------------------stpvqpplp 690  Leishmania major
EAN89094     585 SLGHpirGDKKYIrlaadspsiplrtdlrdeee------------------------------edeeeeeeeskgylssh 634  Trypanosoma cruzi
CAF89720     150 AIGHpivGDVTYScgadag-----------------------------------------------------------py 170  Tetraodon nigr...
CAJ06253     342 AIGFpivGDTSYCadlpwctalplgss-------------------------------------------pstwvtagar 378  Leishmania major
Feature 1                   
1PRZ_A       202 rqaLHATXLRL 212  Escherichia coli
Q12362       399 dlwLHAFRYES 409  baker's yeast
EAL51350     286 giyLHAWRYVI 296  Entamoeba histolytica HM-1:IMSS
CAC22676    1400 raaLHAYTVDI 1410 Leishmania major
ZP_00307802  176 -lfLSEIKRKK 185  Cytophaga hutchinsonii
CAF23430     256 rylLHAEEMGF 266  Parachlamydia sp. UWE25
CAJ05143     691 rggLGATESTT 701  Leishmania major
EAN89094     635 gifLHAWRYTL 645  Trypanosoma cruzi
CAF89720     171 rmmLHAHLLHL 181  Tetraodon nigroviridis
CAJ06253     379 rmyLHAWRLLL 389  Leishmania major

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