Conserved Protein Domain Family
CLCA

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pfam08434: CLCA 
Calcium-activated chloride channel N terminal
The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N-terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage.
Statistics
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PSSM-Id: 462476
Aligned: 24 rows
Threshold Bit Score: 469.883
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3SYU0        24 VRLNNNGYEGIIIAIDPAVPEDETLIEKI-----QNMVIDASTYLFEATEKRFFFKNVSILIPENWKSITQYKRPKHESY 98   cattle
XP_007667306  25 IELKNNGYEGIVIAINPQIPEDEKIIQQI-----QDMVTEASTYLFQATKKMVYFKSVAILIPETWQDKPEYLISKRESY 99  
XP_016284979  24 IQLNGNGYDGIVIAINPSVLEDEKLIQKT-----KEMVTEASTVLFHATNKRAYFRNVSILIPMTWTSKPEYLIPKLESY 98  
XP_008263168  24 VNLNNNGYDGIVIAINPSVPEDEKLIQNI-----KEMVTDASTYLFQATKRRVFFRNVHILVPITWKSKSEYLMPKQESY 98  
XP_024840409  32 VNLINNGYDGIVIAINPSVPEDEKLIENI-----KEMVTEASTYLFHATKRRVYFRNVSILIPMTWKSKSEYFIPKQESY 106 
XP_422360     31 VKLNESGYEDLVVAINPSVTEDANIILNT-----KAMIKDASNYLFEATKHRFFFKSVKIILPKTWKKNSTYSRLKTESY 105 
XP_008107509  23 VTLNNGGFENVIIAINPGIPEDDKIIDSI-----KDMVKDASSYLFSATEQRFYFKSVKIIIPLTWTPKPEYKRVTTESY 97  
2_pfamImport   1 IQLNNNGYEGIVIAIDPNVPEDETLIQNI-----KDMVTQASPYLFEATEKRFYFKSVAILIPEKWKTKPEYVRPKLETY 75  
EHB18742      25 IQLNNNGYEGIVIAIDPTVPEDEGLIQQIkaifpKDMVTEASPYLFEATEKRFYFKSVSILIPQNWKTKPDYVKPKLETY 104 
KAE8610708    24 VKLQNGGYEDLVFAINPGLRENVKIIDNI-----QNMITEASQYLFSATKNRVYIRNAKILIPMAW-SNNKYTKARTETY 97   tropical clawe...
Q3SYU0        99 KHADVRVAPPTLPGRD-----------EPYTKQFTACEEKGEYIHFTPDFVLGNKQ-NEFGPSGRLLVHEWAHLRWGVFD 166  cattle
XP_007667306 100 QTADVIVAEPSPAHID-----------TPYTKQTGLCGEPGQYIHFTPKFLAGDLL-REHGPLGRVFVHEWAHFRWGVFD 167 
XP_016284979  99 EQADVIVADPYLKYGN-----------DPYTLQYGQCGEKGRYIHFTPNFLLGDNL-NIYGPRGKVFVHEWAHLRWGVFD 166 
XP_008263168  99 DQADVIIANPSLKYAD-----------DPYTLQYGQCGDKGQYIHFTPNFLLTNNL-SAYGPRGRVFAHEWAHLRWGVFD 166 
XP_024840409 107 DQADVIVANPYLKYGD-----------DPYTLQYGRCGEKGKYIHFTPNFLLTNNF-HIYGSRGRVFVHEWAHLRWGIFD 174 
XP_422360    106 NKADVIIADPYLKYGD-----------DPYTLQYGGCAMKGRYIHFTPNFLLDSSMiKVYGERGRVFVHEWAHLRWGVFD 174 
XP_008107509  98 DKADIIVADPFLKYGD-----------DPYTLQYGGCGEPGRYIHLTSNFLTNDSMhDVYGPRGRVLVHEWAHLRWGVFD 166 
2_pfamImport  76 KNQNILESNETVPKSScvneviyllikRSQTNVLLCCS-------FT-----TLDL-PTYGSIGRVFVHEWAHLRWGVFD 142 
EHB18742     105 KNADVLV-EPNQPGNE-----------EPYTEQVGKCGDKGERIHFTPDFLAGKML-NQYGLQGRVFVHEWAHLRWGVFD 171 
KAE8610708    98 DKADVIIASSHVKFGD-----------DPYTLQYGRCGEPGKYIHMTPDFLLNDSLiSTYGPRGRAFVHEWAHLRWGVFD 166  tropical clawe...
Q3SYU0       167 EYNDDEPFYRAKSRKIEATRCSTSITGLNRVYM-CEGGSCVTnRECRIDSKTKLYEKNCQFFPDKDQTEKTSIMFMQGID 245  cattle
XP_007667306 168 EYDDKQPFYISSDGHLEATRCSSEIEGKFMMQK-CQGGSCIT-KLCKIVPQTGLLEEGCTFIPNEFQSVTSSLMYMQSLE 245 
XP_016284979 167 EYNLDQPFYITRQNTIEATRCSRNIAGVNRVLK-CSNKSCAI-KMCKTNRKTGMYEAKCQFIPEKSQSAKASIMFMQSLD 244 
XP_008263168 167 EYNVDRPFYSSTKNTIEATRCSTQITGRKVVFReCKGGSCIT-RPCRWDSQTGLYEAKCTFIPDKSQLAKESIMFMQNLD 245 
XP_024840409 175 EYNVDQPFYISRKNTIEATRCSTHITGINVVFKkCPGGSCIT-SLCRRDSQTGLYEAKCTFLPKKSQTAKESIMFMPSLH 253 
XP_422360    175 EYNNDAPFYVSENARVEPTRCSAGVTGKP-VFRnCNGNQCTT-RECQYDGQ--LYEAGCVFVPDLNQNSKNSIMYMQSLP 250 
XP_008107509 167 EYNNDAPFYTTGVNQAEATRCSAGITGQY-IFRsNTGAA----RKCKFEYRTQLYEPGCQFIPDKKQTASASIMYMQSLS 241 
2_pfamImport 143 EYNNNQKFYLLNGKR-EAVRCSARIAGKYQAEH-CQGGSCAW-KPCKIDQATGLYKEGCEFIPNKFQTEKASIMFSPSIN 219 
EHB18742     172 EYNNDEKFYLLKNKP-EAVRCSADITGKYEEVK-CQGGSCVVgRPCSFDKVTGLYKEGCEFIPHKQQTVKTSIMFAQSID 249 
KAE8610708   167 EYNYEKPFYIAGNKNIEATRCSADIIGTH-IKQ-CQGKTC----KCARDPQTGLYEDGCVFVPDKNQVPKASIMYLQALQ 240  tropical clawe...
Q3SYU0       246 SVTEFCNEKSHNQEAPTLQNKMCNYRSTWEVISNSEDFKNTTAML 290  cattle
XP_007667306 246 SVTEFCNKENHNAEAPNQQNRMCELRSTWDVIQGSADFNNTKPMT 290 
XP_016284979 245 SVVEFCTKKTHNPDAPNLQNKMCNHRSTWEVIMASEDFRNLSSMR 289 
XP_008263168 246 SVTEFCTANTHNTEAPNLQNKMCNHRSTWDVIMDSEDFQNASSMA 290 
XP_024840409 254 SVTEFCTEKTHNTEAPNLQNKMCNGKSTWDVIMNSVDFQNTSPMT 298 
XP_422360    251 SVVEFCDKNTHNSEAPNMQNKMCNYKSTWEIIMESDDFRNSSVVN 295 
XP_008107509 242 SAMQFCNKSNHNIKATNMQNKQCNFRSTWEVIMNSSDYASSFPIN 286 
2_pfamImport 220 SVVEFCTEKNHNKEAPNPQNQKCNLRSTWEVIRDSEDFQKTTPMT 264 
EHB18742     250 SVVGFCTEKNHNKVAPNMQNQKCNLRSTWDVISDSEDFKKTTPMT 294 
KAE8610708   241 SVTEFCD-KNHNTEAPTLQNRICNSRSTWDVIMNSTDIKSTPPQA 284  tropical clawed frog
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