Conserved Protein Domain Family
Syntaphilin

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pfam15290: Syntaphilin 
Golgi-localized syntaxin-1-binding clamp
Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.
Statistics
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PSSM-Id: 464617
Aligned: 18 rows
Threshold Bit Score: 411.05
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011471585  58 PPGSPTANRDAdlyaphkTPPRAaLSTTNSSSCNSSPTS-RRVSLGRYHSCGENHGIRPPNPEQYLTPLQQKEVAIRHLK 136
XP_016082314 251 NQMSPVNAHPN-------YGPSS-PSSSNSGSYKGSDSSpVLRRAGRYASCGESHGVKPPNPEQYLTPLQQKEVTVRHLK 322
XP_006921737  62 RTSPPVSVRDA-------YGTSSlSSSSNSGSCKGSDSSpTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLK 134
XP_004177133  14 RRRPSPPGRDT-------YGTSSlSSSSNSGSCKGSDSSpTPRRSSKYNLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLK 86 
XP_003226156  16 RPSPPVSMRDT-------YGTSSlSSSSNSGSCKGSDSSpTPRRPVKYLLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLR 88 
XP_005158281  58 PAGSPSAPRDAelyapirTPPKT-PSFTNSSSCSNSSSSrRRTAPVRYHSCGDNHGIKPPNPEQYLTPLQQKEVAIRHLK 136
CAF96264     114 PAGTPMANRDAelyapykTAPKAaSS-TNSSSCNSSPTSsRRAGLGSYHLCGDNHGVRPPNPEQYLTPLQQKEVAIRHLR 192
XP_005472635 184 PAGNPAANRDAelyapyrTPPRA-ASSTNSSSCTSSPTS-RRAGLGRYHSCGDNHGIRPPNPEQYLTPLQQKEVAIRHLK 261
1_pfamImport   1 PPGSPAANRGAelyapyrTPPRAaSSTTNSSSCNSSPTS-RRVNPGRFHSCGDNHGIRPPNPEQYLTPLQQKEVAIRHLK 79 
XP_016287348   5 NQQSPVNVHPN-------YGPSS-PSSSNSGSYKGSDSSpIMRRPGRYMSCGENHGVKPPNPEQYLTPLQQKEVTVRHLK 76  gray short-tail...
XP_011471585 137 TKLLESENKVCDRETEIEELKGQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDI 216
XP_016082314 323 TKLKESESQLQERETEIAELKSQLTRMRDDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 402
XP_006921737 135 ARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDI 214
XP_004177133  87 ARLKDTQERLQDRDAEIEDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLLEKDKGLQKYFVDI 166
XP_003226156  89 ARLKDTHERLQDRDSEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIEKDKGLQKYFVDI 168
XP_005158281 137 TKLRDSENTVCDRESEIEELKSQLGRMREDWIEEECHRVEAQLALKEARKEIKQLRQVVETMKNSLMEKDKGIQKYFIDI 216
CAF96264     193 TKLLESENRVHDREAEIQDLKTQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDI 272
XP_005472635 262 TKLLESENRVHDRETEIEELKAQLSRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDI 341
1_pfamImport  80 TKLLESENTVRDRETEVGELKSQLGRMREDWIEEECHRVEAQLSLKEARKEIKQLRQVVETMKSSLMEKDKGIQKYFIDI 159
XP_016287348  77 TKLKESESRLQERETEIAELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDI 156 gray short-tail...
XP_011471585 217 NIQNRKLESLLHSMELAQSGSsLQDENPLDFMCDSSDGS----------GRKMLrmeeggIELGDQGAEALADSGllVND 286
XP_016082314 403 NIQNTKLESLLQCMEMAQNGC-FREELCLEYLVESPGQSvplspactplARGLA------LEDQAGALEELGETP--APD 473
XP_006921737 215 NIQNKKLETLLHSMEVAQNGT-AKEDGTGESAGGSPARSltrsstytklSDPAVcgdlppGDHPASSAEDGADSGfvAND 293
XP_004177133 167 NIQTKKLETLLHSMEVAQNGA-PKEEGAGESAGGSPARSltrsstytklSDQGAggr-nvGGSQTISLDEGADSGfvGME 244
XP_003226156 169 NIQNKKLETLLQTMEVAQDGA-GKEEGAAESAGGSPARSltrsstytklSDQGAadr-niGGSQTISVDDAADSGfaAAD 246
XP_005158281 217 NIQNRKLESLLHSMELAQNGCnLQDEPTLDFICEAPESS----------TEAKMel---eLHCGEQAVEEMANSEllIND 283
CAF96264     273 NIQNRKLESLLRSMELAQSGTnLQDENTLDFLCERPNGG----------GNKLVgeeghgLEMGEQGVEAMADSGllIND 342
XP_005472635 342 NIQNRKLESLLQSMELAQSGAnLQDENTLDFMYDSSDGS----------GKKMVgdeegaMEVGHQGAEAMADSGllAND 411
1_pfamImport 160 NIQNRKLESLLQSMELAQSGTsLQDDNTLDCICDGPGPC----------GKKMVgdeeggLELGTQGAEAMADSGllAND 229
XP_016287348 157 NIQNKKLESLLQSMEMAQNGS-LRDEQCLDYLCDSPEKSlppntaygkmADARA--------LEDQTIEEGAESEllAIE 227 gray short-tail...
XP_011471585 287 EMANSADIF--------------EQVFMSTAVDFSQDSSNNpgaag-----esgaLSEEE----QMASASTAPLS--PKT 341
XP_016082314 474 SLPTGLDLF--------------EEFMTAATTESGEVAVFQ--------------SSAAP----APPDQMAPAVE--DSV 519
XP_006921737 294 DTMSRTDALeassllssgvdcgpEEASLHSSFSLGPRFPAS--------------NTYEK----LL---CGMEAGvqASC 352
XP_004177133 245 EAPGHTDPL-------------------EVGGEPGTRLPPS--------------NTYEK----VLGLRSSVEAG--VQA 285
XP_003226156 247 DSLSRTDFLdqsslissgvdcgtDEISLQTNSTLGSRVPTS--------------STYEK----LMGSQQSVEAAvqVSC 308
XP_005158281 284 EMVNRVEIL------------------MSTAVDSSQDGSTKiisq-------pglSCLEP-----------------SVS 321
CAF96264     343 EIASRVDIL--------------EQVFMSTAVDFSQDCKRRadp---------gvSTLSEdplmIGEPPKPRsnpissa- 398
XP_005472635 412 EMANRADIL--------------EKVFMSTAMDFSQDCSSKlrasaesgpgvsalSGERQl---TDSSTGTQPTL--PDM 472
1_pfamImport 230 EMANRADIL--------------EQVFMSTAVDF-------------------------KegrlIEDSIGPPPALpnNMA 270
XP_016287348 228 NVENSTDLF--------------EEIMMATTTEAGDLSLLH--------------STSIS----SPFKTKAFEMG--PVT 273 gray short-tail...
XP_011471585 342 lfsps----pcqqnTEDKGIQTELMPVSPDLQALL 372
XP_016082314 520 --------------VMEQVVQLDMAPCGPGIEQPL 540
XP_006921737 353 --------------MQERAIQTDFVQYQPDLDTIL 373
XP_004177133 286 s------------cMQERAIQTDFVPCQPDLDTIL 308
XP_003226156 309 --------------MQEQAIQTDFVPYQPDLDTIV 329
XP_005158281 322 ekstkehvssipigAEDKGIQTDDVIYSTDLQTLL 356
CAF96264     399 --------tsvkqsTEDKGMQTDAMPCSPDLSALV 425
XP_005472635 473 vais------gtlpHQDKEVQADIMPMPPDLQALL 501
1_pfamImport 271 sitisms-apsqqdTEDKGMQTDMLPVGPDLQAVL 304
XP_016287348 274 qee--------dsmVTEQAIQTDVVPYSPDVEQLI 300 gray short-tailed opossum
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