pfam05871: ESCRT-II (this model, PSSM-Id:399106 is obsolete and has been replaced by 461763)
ESCRT-II complex subunit
This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB). This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo.
Jiyao W et al.(2023). "The conserved domain database in 2023.",