1CPZ,1FVQ,1AFJ,2AW0,1JK9,1CC8,1FE4,1K0V


Conserved Protein Domain Family
HMA
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cd00371: HMA 
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Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.
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Statistics
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PSSM-Id: 238219
Aligned: 105 rows
Threshold Bit Score: 30.6517
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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metal-binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:metal-binding site [ion binding site]
Evidence:
  • Comment:conserved metal binding sequence motif: M-[T/H]-C-X-X-C
  • Structure:1K0V_A:B. subtilis copper-transport CopZ protein bound to Cu ion
  • Structure:2AWO: human Menkes Copper-transporting ATPase bound to Ag ion
  • Citation:PMID 9437429
  • Structure:1FE4_A: Hah1 metallochaperone protein bound to Hg ion
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###  #                                                    
1CPZ_A      3 EFSVKgMSCNHCVARIEEAVGRIsGVkKVKVQLkkeKAVVKFDeanvQATEICQAINELGYQAE 66  Enterococcus hirae
1K0V_A      5 TLQVEgMSCQHCVKAVETSVGELdGVsAVHVNLeagKVDVSFDadkvSVKDIADAIEDQGYDVA 68  Bacillus subtilis
3108347    24 EFMVD-MTCEGCVNAVKNKLETIeGIeKVEVDLsnqVVRILGSs---PVKAMTQALEQTGRKAR 83  thale cress
3929319    12 EFMVD-MTCEGCVSAVKNSMLKLdGVsGVDVDLsnqLVRVIGSv---PVKTMLKALEQTGRNAR 71  Dendrobium grex Madame Thong-In
6522569     4 EIRVPnLDCEGCASKLRKTLLKLkGVeEVEVEMetqKVTARGYr--lEEKKVLKAVRRAGKAAE 65  thale cress
4469010    19 EMMVP-LYSYGCEKKVKRALSHLkGIySVKVDYynqKVTVWGIc---NKLDVLAMVKKKRKEAR 78  thale cress
3377812    29 ALRVArIDCEGCERKIKHVLSGVkGVkSVDVDVklqKVTVTGYi---DPKKVLEAAKSTKKKVE 89  thale cress
18424719  174 VLKVH-MHCEACATEIKKRIMRMkGVeSAESDLkssQVTVKGVf--ePQKLVEYVYKRTGKHAA 234 thale cress
5759320    95 EFMVD-MSCQGCVSAVKSKLQTVeGVkNVDVDLdnqVVRILGSs---PVKTMTEALEQTGRKAR 154 tomato
3080439    35 ELKVR-MDCDGCVLKIKNSLSSLkGVkTVEINKkqqKVTVSGYa---DASKVLKKAKATGKKAE 94  thale cress

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