4JNB,4KI9


Conserved Protein Domain Family
DSP_DUSP12

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cd14520: DSP_DUSP12 
dual specificity phosphatase domain of dual specificity protein phosphatase 12 and similar proteins
Dual specificity protein phosphatase 12 (DUSP12), also called YVH1, functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). It deactivates its MAPK substrates by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. DUSP12 is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. It targets p38 MAPK to regulate macrophage response to bacterial infection. It also ameliorates cardiac hypertrophy in response to pressure overload through c-Jun N-terminal kinase (JNK) inhibition. DUSP12 has been identified as a modulator of cell cycle progression, a function independent of phosphatase activity and mediated by its C-terminal zinc-binding domain.
Statistics
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PSSM-Id: 350370
Aligned: 20 rows
Threshold Bit Score: 194.391
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:4KI9: Human DUSP12 binds a phosphate ion in the active site; contacts at 4A
  • Comment:also based on the structures of some DUSP family members with bound phosphorylated substrates (peptide and non-peptide)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                                                    
4JNB_A         1 MLEVQPGLYFGGAAAV--AEPDHLREa-GITAVLTVDseepsfk------------------------------------ 41  human
4KI9_A         1 MLEVQPGLYFGGAAAV--AEPDHLREa-GITAVLTVDseepsfk------------------------------------ 41  human
EAY79854       2 PHLVRERLFFGDINDAiaALTTTTAEagGFTHLLSVVssasisfitdcrpglsipteevrrvva---------------- 65  Indian rice
XP_002984182   1 MKKVREGLYIGCLDDA--LKYLFGSEs-GITHVLSLAslnfltddkslnafsafrmraslrsslm--------------e 63  Selaginella moe...
XP_002981726   1 MNEIREGLFLGSIDDA--VSCLVGRHssKISHVLSVAnihlsdkaietrs------------------------------ 48  Selaginella moe...
XP_002883256   4 LDLVRENLYLGDICAA--AEILKNGSa-EISHLLTVFhcpsisvfeewrnvkldskqikemyvgdddq--------ddsl 72  Arabidopsis lyr...
XP_002977472   1 MKKVRDGLYIGSAEDA--EMFLCGEKr-GVTHILSLEkvrdirllkkerrrnrdhpklsklqqall------------ds 65  Selaginella moe...
XP_002975977   1 MKKVRPGLYIGNQFDA--FYFLTGKHr-GVTHILSVVplcpghefstplgpprdna------------------------ 53  Selaginella moe...
ABK24703       2 PVKVREGLLIGDINDA--AEVISNGSs-EITHVLSLLssasitffsdwrrgfeaqhkeiekvykeingrnnkkanpgnas 78  Sitka spruce
XP_002977192   1 MKKVRDDLYLGDIGDA--LLFLSGTKa-GVTHVLSVLplcpnheskdfvpygppsd------------------------ 53  Selaginella moe...
Feature 1                                             #                              #######     
4JNB_A        42 ---------------------agpgveDLWRLFVPALDKpeTDLLSHLDRAVAFIGQARAEGrAVLVHSHAGVSRSVAII 100 human
4KI9_A        42 ---------------------agpgveDLWRLFVPALDKpeTDLLSHLDRAVAFIGQARAEGrAVLVHSHAGVSRSVAII 100 human
EAY79854      66 geegappvsavapgrlmrvveragvglRVTRMAVPLRDTeeENLLDHLEPCLDFIDEGRKEG-NVLVHCFAGVSRSATII 144 Indian rice
XP_002984182  64 svknpnadaaasrpepvtaeqaaanraKLVRKTVPLIDTeaQNLLDYLEECLEFIDKGRSEG-SVLVHCVAGISRSATVI 142 Selaginella moe...
XP_002981726  49 --------------qitrnerkqmpkrDLVRKEVPLVDSetQNILERLEECLDFIEHGRQHG-GVLVHCLQGISRSASVV 113 Selaginella moe...
XP_002883256  73 qgkefatesalpsgnllyslehtgkdlKFTRMVVFAYDQewENLLDLFDICLDFIDAGRKEK-GVLVHCFAGQSRSASMV 151 Arabidopsis lyr...
XP_002977472  66 skpkpddeafrdvarellakckdaavaKPVRKVFLLEDTmeEDLLACLGECLDFVEKGREDG-IVLVHCGAGISRSAAVI 144 Selaginella moe...
XP_002975977  54 ---------ilykiaaeldtkraefdgAIVRKVIPVEDShdENLLEHLEDALKFIDEGVNKG-IVLVHCGGGISRSASVV 123 Selaginella moe...
ABK24703      79 gsssdeelpptqagkllynlelvgpelKILRMAVPLRDMenENLLDYLDTCLDFIERGRREG-AILVHCYAGVSRSASVV 157 Sitka spruce
XP_002977192  54 --------anaffrvsvelqnkcdfsgLPIRKVVPLEDSadENLFERLEECLEFINRGVQEG-IVLVHCGGGFSRSPSIM 124 Selaginella moe...
Feature 1                                                       
4JNB_A       101 TAFLMKTDQLPfEKAYEKLQILKPeAKMNEGFEWQLKLYQAMGYEVD 147 human
4KI9_A       101 TAFLMKTDQLPfEKAYEKLQILKPeAKMNEGFEWQLKLYQAMGYEVD 147 human
EAY79854     145 VAYLMRTEQKSlEEALESLKEVNEsACPNDGFLEQLKLFEEMGFKVD 191 Indian rice
XP_002984182 143 TAYLMRSERLIlKEALASLKECSKtACPNKGFKRQLQMFEEMGCVVD 189 Selaginella moellendorffii
XP_002981726 114 TAYLMRSERLSvKDALASLRLHNEmICPNPGFMHQLELFYEMKFTAD 160 Selaginella moellendorffii
XP_002883256 152 IAYLMRTEKLSrEEALASLRQSAQ-ASPNLGFLKQLDLFERMNFKVD 197 Arabidopsis lyrata subsp. lyrata
XP_002977472 145 TAYLMRKENLLrDEALASLRECSPqVSPNDNFMLQLQIFENAGCVCG 191 Selaginella moellendorffii
XP_002975977 124 IAYLMWKEKLSaSEALASLRKCSPtVKPNSGFMKQVFESSGCVVRVH 170 Selaginella moellendorffii
ABK24703     158 MAYLMKMERLSqEDALKSLREQNEfVCPNDGFLEQLKMFEDMGFEVD 204 Sitka spruce
XP_002977192 125 IAYLMWKEKLSfADALASLKKSSPsVDPNPGFVKQLKAFETNGFKVP 171 Selaginella moellendorffii

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