Conserved Protein Domain Family
bHLH_TS_MIST1
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cd19711: bHLH_TS_MIST1 
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins
MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription.
Links
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Statistics
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PSSM-Id: 381554
Aligned: 5 rows
Threshold Bit Score: 118.665
Created: 3-Aug-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   # ### #    #                 ####                        
Q7RTS1        76 RRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSS 137 human
NP_001071120  77 RRLESNERERQRMHKLNNAFQALREAIPHVKTEKKLSKIETLTLAKNYIKALTTIILGMSNG 138 zebrafish
OCT64195      67 RRLESNERERQRMHKLNNAFQALREVIPHVRAEKKLSKIETLTLAKNYINTLTATILNMSSG 128 African clawed frog
XP_006000846  69 RRLESNERERQRMHKLNNAFQALREVIPHVKAEKKLSKIETLTLAKNYIKCLTTTILNMSNG 130 coelacanth
KFQ21198      67 RRLESNERERQRMHKLNNAFQALREVIPHVRAENKLSKIETLTLAKNYIKSLTSTILSMSNG 128 brown roatelo

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