Conserved Protein Domain Family
EAL
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cd01948: EAL 
EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second messenger, cyclic di-GMP, and is a good candidate for a diguanylate phosphodiesterase function. Together with the GGDEF domain, EAL might be involved in regulating cell surface adhesiveness in bacteria.
Links
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Statistics
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PSSM-Id: 238923
Aligned: 386 rows
Threshold Bit Score: 89.1419
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6580642     455 TALPAALERgeffIEYQPLVHlgdg--svrGAEALVRWLHPQHgv--lgPDRFIPLAEh---TGLIVPLGRWVLEQSVRQ 527 Streptomyces coe...
NP_385058    20 VTLAKLVIE----NALQPIVEattg--avfGYESLMRGFERLGfa---sPVELLDKAEa---AGQLLALEHLINSRAVAA 87  Sinorhizobium me...
NP_250823    28 RRFQAALARgrvrLDWQAVRHaghpeweplYRETLLRVTAASGep--plPTQELILALe--rLGLVRLLDRCVLGTVLDR 103 Pseudomonas aeru...
YP_051637     6 LNIDGEILRl--tAEFQPIIHlpkn--kifRYEALARFYNSEGal--tpTQQTIDKIEk---CQAIDKVTDFMFDVVCQV 76  Erwinia carotovo...
AAQ87269     11 GGAVRAMQHgrigFSLQKINAvddp-stilYSECLGRFVEPDGtv--rtRGEFSAFPEa---SQVDLAFGPDLLGLAFEW 84  Rhizobium sp. NG...
YP_051360    30 ADYWHQCQRr---YTFQPIYRtsg---klmAIELLTSVFSPTL------PQKFISPEKy--fANIDVETRLLIIVEQLQL 95  Erwinia carotovo...
YP_072309    46 QSFWRQCQRr---YTFQPIYRtsg---allAIELLTAVFHPSApetrlsPEDYFSTISt--gARLDVVLEQLNMVKQWHQ 117 Yersinia pseudot...
NP_796755    12 TTIRSERSCvtleFLLQPIYLpkng--qtvYYEALSSVISDSGehl-nsEAFFETINDefikTVLLLQMEHFSQSNSISQ 88  Vibrio parahaemo...
YP_110809   159 VAFRQSLRSnlsyLSFQPIVRrnsa-pavlYEQALLSIVGDDDqsg-ehPASIIAALEr---LGLARLFDYRVVHAVVAR 233 Burkholderia pse...
ZP_00270821   9 ADLSSLGRD----VALDPVISlrsg--rviGYQAVAGPPPGGR------EEDDLLLREaieaAVWSSAIALFAAVSAGRD 76  Rhodospirillum r...

6580642     528 arvwrerygesgaagplrINVNLSPCqlt-hpgLVQDTVEILERTGVap--daLCLEVTESALIgadd--dllkPLRRLA 602 Streptomyces coe...
NP_385058    88 fatlpd-------fsartLFLNFDARliggegdIVERLVSHLKRANIap--ssLCFELSERFDSskmp--dfpvLVRQLR 156 Sinorhizobium me...
NP_250823   104 lnae----------ptlrLACNLSRQsaa-mdaWWEAVCRWLAARPQva--rrLTLELTETAVGerva---treFIRRLR 167 Pseudomonas aeru...
YP_051637    77 iknk----------nsmtISFNLSHLlfn-ntlYLESLYQKCLSNNVsp--qnIEIEISEKTTRqqli--dgipFLNQAK 141 Erwinia carotovo...
AAQ87269     85 lach----------psyvLGCDISAEnma-derTCTVLYDLLSRHRAla--trMVLEVTENLRPngls--vaadLLKGAR 149 Rhizobium sp. NG...
YP_051360    96 lsqwnfr----firddlfASVNIDGM-------TLLALQNNLEAKRLiaampwIRFEMVENQGGlp------keILTKLP 158 Erwinia carotovo...
YP_072309   118 ifvh----------hsvlVSINIDGQv------LVAMQEDHAAKRLIdam-pyIRFELLEHVDTsl------dtPFARIA 174 Yersinia pseudot...
NP_796755    89 di---------------lLNVNLSSLk------DDDFIESIIKRNKSn----kYHIEVNEIDTPvrdv--kilkNIKRLQ 141 Vibrio parahaemo...
YP_110809   234 llrt----------sdarLGCRISPRsam-ldvWWASLVDWLASHPCva--rrFTVEIPCNTPVtrra--aalaFVRKLQ 298 Burkholderia pse...
ZP_00270821  77 qr--------------lfLGLDFGLVvrw--pdMAARLAMLLDAHGVdr--rvITLSLSERRSIldlgggsgerALDRVA 138 Rhodospirillum r...

6580642     603 EMGVd-------IALDDFGTGYSnl-anLRRLPVSVLKLDRSFTQSmqqfpadpvdLKIVEGIVALAHs---LDLAVTVE 671 Streptomyces coe...
NP_385058   157 LAGFk-------LAIDDFGAGFSgl-klLCDQPVDYVKIDRHFVSEidkd---arkRHLVRHTVNMAHa---LGTRVIAE 222 Sinorhizobium me...
NP_250823   168 EHGVr-------IAIDDFGAAHNnl-dfVLDARPDVIKIDCRYTREarrs---akgAEVLRHLLALCRe---LAPCVVLE 233 Pseudomonas aeru...
YP_051637   142 KYGFm-------ISLDDFGAGNLqi-dsLSLFNFDTIKIDRSIIDGigke---etkSQKLKVLLNKLIp---LGVNIICE 207 Erwinia carotovo...
AAQ87269    150 AIGYr-------IAIDKFGTGNS-----RLSIPADAVKIDACFAQHrrg-----daAPILRDMVALASc---AATTVVVE 209 Rhizobium sp. NG...
YP_051360   159 EAQT--------LWLDDFGCGMAnf-ssLMLAQYDCIKVARELFILlqqs---segRTVFPALIALLSr---FCNYVVIE 223 Erwinia carotovo...
YP_072309   175 EADR--------LWLDDFGSGLAnf-tsFISWRYEYIKVARDLFTVlqds---eagNRLFFTLVTLMDr---YSKGVIVE 239 Yersinia pseudot...
NP_796755   142 KSGIy-------IILDDYYHENEvahlsLGVIDWDYIKIDKSFLLYns------gnDDCLKALIFVISp--yCKNGLIIE 206 Vibrio parahaemo...
YP_110809   299 TLGCs-------VAVTDFDTGGCdl-efALLARPQVVKISAGALRAlp------agNSLAERLARLVRpcssFDPQIVVE 364 Burkholderia pse...
ZP_00270821 139 GAVVqmrgavgsIALDGFGGGHAgl-alLAAVKPDYVVLDPYFVSTqaid---qtrRLFLGHLVDVAHl---LGAQVIAP 211 Rhodospirillum r...

6580642     672 GVETGAQAEQLRiLGCDTAQGWYYARPGPPDR 703 Streptomyces coelicolor A3(2)
NP_385058   223 GVETEAEFLVCRdLGCDLMQGYFIARPTTHIM 254 Sinorhizobium meliloti 1021
NP_250823   234 GLEEDDAFARLP-TGDVYLQGNAIAPPMRVEP 264 Pseudomonas aeruginosa PAO1
YP_051637   208 GVEKATDLNRLNkYHPIGIQGYIFYRPLTFSQ 239 Erwinia carotovora subsp. atroseptica SCRI1043
AAQ87269    210 GIETYDQLEAARiAGATHVQGFLLSEPTLPPI 241 Rhizobium sp. NGR234
YP_051360   224 GIETQEEWAIVQaSHAYAAQGYYLSRPQPFEN 255 Erwinia carotovora subsp. atroseptica SCRI1043
YP_072309   240 GVETSQEWAMVQrSDAVAAQGYYLSRPTSFDG 271 Yersinia pseudotuberculosis IP 32953
NP_796755   207 GVETYFQNEFVK-KYNLLAQGYYYSRPKNIFK 237 Vibrio parahaemolyticus RIMD 2210633
YP_110809   365 GVNDPHDLNVLEaVDAAWVQGLLQSAAVNGSR 396 Burkholderia pseudomallei K96243
ZP_00270821 212 QVEHLADYHACRdAGCDLVRGPVLAKPDRDPR 243 Rhodospirillum rubrum
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