3VGL,3VGM,3VGK


Conserved Protein Domain Family
ASKHA_NBD_ROK_SgGLK-like
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cd24061: ASKHA_NBD_ROK_SgGLK-like 
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins
Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Links
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Statistics
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PSSM-Id: 466911
Aligned: 12 rows
Threshold Bit Score: 336.633
Created: 13-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:DClick to see conserved feature residue pattern help
Evidence:
  • Comment:The catalytic Asp of ROK family proteins forms a bidentate hydrogen bond with glucose (C4 and C6 hydroxyls).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3VGL_A         4 TIGVDIGGTKIAAGVVdeEGRILSTFKVATppt-aeGIVDAICAAVAGAseghdvEAVGIGAAGYVddKRATVLFAPNId 82  Streptomyces gr...
3VGM_A         4 TIGVDIGGTKIAAGVVdeEGRILSTFKVATppt-aeGIVDAICAAVAGAseghdvEAVGIGAAGYVddKRATVLFAPNId 82  Streptomyces gr...
3VGK_A         4 TIGVDIGGTKIAAGVVdeEGRILSTFKVATppt-aeGIVDAICAAVAGAseghdvEAVGIGAAGYVddKRATVLFAPNId 82  Streptomyces gr...
TNV70903       4 TIGIDVGGTKVLGGVVdeNGKILATARKETprqggsELTRTIADTAKELmaqfkvSSVGVSAAGFVssDRKTMLATPNIa 83  Halteria grandi...
P0A4E1         4 TIGVDIGGTKIAAGVVdeEGNILSTHKVPTptt-peAIVDAIASAVEGArvgheiVAVGIGAAGYVnrQRSTVYFAPNId 82  Streptomyces co...
WP_020487701   6 TVGVDIGGTNILAGVVteSGEILASARRATdasdpdQIERAVAEAVGELqatypvAGVGVAAAGFVsaDRRKLLFAPNIa 85  Dehalobacter sp...
VDG63239       3 TIGFDIGGTNTRAGVVdkHGEIVDVEDTHTphd-adGLTHAIVELVEVLrrrhpiGAVGLAVAGFLdpDCKVVRFAPHLp 81  Streptococcus t...
WP_047566554   3 AIGIDIGGTKIAGALVteQGEIIAERREPTpagdpsAITELVVRMIEQLreghdvIAAGVAAAGFIdaAQSTVYYAPNIn 82  
WP_150890197   3 NVGIDIGGTKIAGGVVdaAGGILEKLRVDTpvd-vsELVDAVVGMAEELrgrhvvSGIGVAAAGFIdrERSTVIHAPNIa 81  Leclercia adeca...
TXJ07498       6 GIGVDIGGTKTAIGVVtaTGELLERVVVATpkesaqQLIDVITQTTSELaqrfafTTMGVAIAGLVdaNQAKVAYATHLp 85  Aeromicrobium sp.
CAD67224       4 AIGVDIGGTKISAALVdrSGNMDGQLTVPTdp---vGVIDQVVELVNKLsdgesvCAVGVAVASFLnySRDFVYNSPNLg 80  Tropheryma whip...
TQJ66641       4 SLGIDIGGTKIASAVLdhDGTVMDVETTPTarg-gdLILEQIAAIVDGFagkydlPGIGIAVPGDVnpITGIIRSAPNIg 82  

Feature 1                                 #                                                      
3VGL_A        83 w-rHEPLKDKVEQrv--glPVVVENDANAAAWGEYRFGagq----ghDDVICITLGTGLGGGIIIGNKLRRGrfGVAAEF 155 Streptomyces gr...
3VGM_A        83 w-rHEPLKDKVEQrv--glPVVVENDANAAAWGEYRFGagq----ghDDVICITLGTGLGGGIIIGNKLRRGrfGVAAEF 155 Streptomyces gr...
3VGK_A        83 w-rHEPLKDKVEQrv--glPVVVENDANAAAWGEYRFGagq----ghDDVICITLGTGLGGGIIIGNKLRRGrfGVAAEF 155 Streptomyces gr...
TNV70903      84 dwnGVDLDADLTAqi--glPVVIENDANAAAWGEAKFGagr----nqNHMMMLTVGTGIGGGIVVNGSLYRGafGIAAEF 157 Halteria grandi...
P0A4E1        83 w-rQEPLKEKVEArv--glPVVVENDANAAAWGEYKFGggk----ghRNVICITLGTGLGGGIIIGNKLRRGhfGVAAEF 155 Streptomyces co...
WP_020487701  86 w-rDHPLADRLEAli--grPVVIENDANAAAWAEYRFGqgr----gtTDMVMLTLGTGLGGAIITGGHLVRGafGAAAEL 158 Dehalobacter sp...
VDG63239      82 wqdNEPVKSLLEEel--elPVRLEHDANAAAWGEYRYGaaq----dvDTWVFFAVGTGIGATLMHHGEIYRGsfGTAPEF 155 Streptococcus t...
WP_047566554  83 w-rNEPFRDRLRAri--dlDITIDNDANAAGWAEFRFGagr----daHDMTMLTIGTGVGGAIVVGDRLLRGgfGTAGEL 155 
WP_150890197  82 w-rNEPLRAILQDrl--gaPVSIENDANAAGWGEFRFGagr----grRDIVMLTMGTGVGGAVVADGALYRGghGIGGEL 154 Leclercia adeca...
TXJ07498      86 v-rGLAMKAQLEAat--glTVLIENDATAALWAEWAWGaar----elQNSVMVAIGTGIGGGFVVDGHVQRGatGLSGEI 158 Aeromicrobium sp.
CAD67224      81 l-eNIPIRNLLQNri--kfPVFIENDANAAAWAEWRFAprsveivnsQDLFMITVGTGVGGAAILDGKILKGgfGIASEP 157 Tropheryma whip...
TQJ66641      83 w-tDLDIVEHVRAllpaeaAVRVDNDANAAAWAEYRFGghp----rtDSFAMITVGTGLGGGFVINGRLLRGatGAAGEI 157 

Feature 1                                                                                        
3VGL_A       156 GHIRVVPDGlLCGCGSQGCwEQYASGRALVRYAKQRANATpenaavllglgdgsvdgieGKHISEAARQGDPVavdsFRE 235 Streptomyces gr...
3VGM_A       156 GHIRVVPDGlLCGCGSQGCwEQYASGRALVRYAKQRANATpenaavllglgdgsvdgieGKHISEAARQGDPVavdsFRE 235 Streptomyces gr...
3VGK_A       156 GHIRVVPDGlLCGCGSQGCwEQYASGRALVRYAKQRANATpenaavllglgdgsvdgieGKHISEAARQGDPVavdsFRE 235 Streptomyces gr...
TNV70903     158 GHLRVVPDGhLCGCGARGCfEQYASGNALLRHAREAINASpeiarnllsrgdgtvagltGKAITDAAREGDPValaaFNT 237 Halteria grandi...
P0A4E1       156 GHIRMVPDGlLCGCGSQGCwEQYASGRALVRYAKQRANATperaevllalgdgtpdgieGKHISVAARQGCPVavdsYRE 235 Streptomyces co...
WP_020487701 159 GHIKIVPDGhYCGCGQEGCwEAYSSGTALGKLAQSVATTDpegskamla--ladgqplaGQHVTAAARAGDPVatrlLRR 236 Dehalobacter sp...
VDG63239     156 GHITVVQGGrACSCGKQGClERYASGTALVDTAIEIAAKGgfepctlyr--savdkratGNDVVTAARNGDALalatMDD 233 Streptococcus t...
WP_047566554 156 GHLRVVPDGlPCGCGARGCiEQYGSGRALLRMANEIADAGgiglqlala--rqeaggltGEILAEHLRAGDAGalhaLRQ 233 
WP_150890197 155 GHVRFERNGlRCGCGQNGClEQYASGRALQREAAVLAEEDgrgaalraa--raedgvihGAEISRLVMAGDPGaleaLRR 232 Leclercia adeca...
TXJ07498     159 GHLRFVPDGiACPCGLNGCwEQYGSGRVLDRWAQAEIAAQssistklie-qagsverisGRTVSELARAGAPEavkcLEE 237 Aeromicrobium sp.
CAD67224     158 GHIVLVPDGiPCGCGKRGCsEQYASGTALLRYVKSNMPDFpfg-------------rnpSDVIGELVAKSDPVvlsaVSQ 224 Tropheryma whip...
TQJ66641     158 GHLALVPGGdSCPCGSRGCwERYASGSALQRASVAAGWDNpt----------------aGQDVLSAAGTHPAAhq-vVEG 220 

Feature 1                                                                                     
3VGL_A       236 LARWAGAGLADLASLFDPSAFIVGGGVs-dEGELVLDPIRKSFRRWLiggewRPHAQVLAAQLGGKAGLVGAADLAR 311 Streptomyces grise...
3VGM_A       236 LARWAGAGLADLASLFDPSAFIVGGGVs-dEGELVLDPIRKSFRRWLiggewRPHAQVLAAQLGGKAGLVGAADLAR 311 Streptomyces grise...
3VGK_A       236 LARWAGAGLADLASLFDPSAFIVGGGVs-dEGELVLDPIRKSFRRWLiggewRPHAQVLAAQLGGKAGLVGAADLAR 311 Streptomyces grise...
TNV70903     238 TGQWLGAGIASLSVLLDPACVVIGGGVi-dAGEILLKPTREALERTMpfagkHPYPELIAAELGNEAGLVGVADLAR 313 Halteria grandinella
P0A4E1       236 LARWAGAGLADLASLFDPSAFIVGGGLs-dEGDLVLDPIRKSYKRWLvggnwRPVADVIAAQLGNKAGLVGAADLAR 311 Streptomyces coeli...
WP_020487701 237 FGKYLGIGIATIAAVTDPQIVVIGGGIasaAGDFILPAARKAFLQRLsgrgfRGELTITTASLANNAGIIGAADSAR 313 Dehalobacter sp. FTH1
VDG63239     234 FACWLGQGLSIVGDVLDPELIVLGGGVs-aDADLFLDSAYTAMRRNMvgsgfRPIPRLQTADLGPQAGMIGVADLAR 309 Streptococcus ther...
WP_047566554 234 LGTWLGQACASLSAVLDPELFVFGGGVs-vAGDELLGPVREAYLAHLpargyHPEPRFVVAELVNDAGVVGAADLAR 309 
WP_150890197 233 VATALGEACGGFQATLDPELFVIGGGVa-qLGDVLLEPIRLAYETSLpgygdRPVAEFAVAQLGNDAGLIGVADLAG 308 Leclercia adecarbo...
TXJ07498     238 LGRNIGIGMASLATILDPELFVIGGGLl-dNKELLLGPMSEAFEQHLfardhRAIPRIVPAACGPDAALIGAAGQLL 313 Aeromicrobium sp.
CAD67224     225 VADNVGRTAAAVTAILDPELFVIGGGVs-kIGTFFIDSIRESYKEYLphsesRPCANFRLAHFYNTAGIIGAADLAR 300 Tropheryma whipple...
TQJ66641     221 VARDLTRGILLLSSALDPSLVILGGGLg--SDRRFLAIAQEALAGAEvt-ppRSRPQLRTAVLGPLAGAIGAADLSL 294

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