pfam13890: Rab3-GTPase_cat (this model, PSSM-Id:404730 is obsolete and has been replaced by 464022)
Rab3 GTPase-activating protein catalytic subunit
This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2.
Jiyao W et al.(2023). "The conserved domain database in 2023.",