1MJH,1JMV,1TQ8


Conserved Protein Domain Family
USP_Like
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cd00293: USP_Like (this model, PSSM-Id:238182 is obsolete and has been replaced by 467483)
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Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, athough Usp lacks ATP-binding activity.
Links
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Statistics
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PSSM-Id: 238182
Aligned: 805 rows
Threshold Bit Score: 34.2678
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Ligand Binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Ligand Binding Site [chemical binding site]
Evidence:
  • Structure:1mjh_b, ATP binding sites determined by 3.5A distance
    - View structure with Cn3D
  • Comment:Although proteins of USP family share the /bea/alpha fold for ATP binding, not all other proteins in this family binds ATP
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###                                            #                            
1MJH_B        7 KILYPTDf-------------SETAEIALKHVKAFKtl----kaEEVILLHVIdereikkrdifslllgvaglnksveef 69  Methanocaldococc...
AAF96072      6 NILFATQg-------------LPGHSDALEQAIQLAynnr-gqlAGLIAFPAFp-------------------------- 45  Vibrio cholerae ...
NP_279740    11 CFMVAAQavsgmdraiavveaSDSAKQLVEEAGELAag----vgADLLLLHVTtet------------------------ 62  Halobacterium sp...
NP_440274   156 NLLVPYDa-------------SSAGNYLIERLKSALekappgkvESCYFLSILedgmrrpe------------------- 203 Synechocystis sp...
ZP_00109960 616 KILVPTVg-------------TEYSKNAVEMASTIAaq----tgALVMIVNVInlpqv---------------------- 656 Nostoc punctifor...
NP_866284     6 NILVYAG--------------TEQPETSVSKATELAla----ngARLTLMDVVkpipralgmltdv------------aq 55  Rhodopirellula b...
NP_968999   157 NILFPTEf-------------GEHSKDNFRHVLELAkn----lkSGVTLLHAIarpie---------------------- 197 Bdellovibrio bac...
CAG23544      5 QLLIPIAp-------------EQPLGDSFHQALRCAns----naSQVTLLMVIeelaelreianhsgt--------tldl 59  Photobacterium p...
ZP_00300638   6 RILVVSRm-------------TTYCQEAVHCGVSLArk----ygAELFLIHAIhnpfglegwnlpv------------vs 56  Geobacter metall...
CAG35472      4 KILVPIAf-------------SQHSQGMLDYAAELAes----ldAELLIVNIIstrdieave------------------ 48  Desulfotalea psy...

Feature 1                                                                                       
1MJH_B       70 enelknklteEAKNKMENIKkel-------------------------edvGFKVKDIIVVGip--------------he 110 Methanocaldococc...
AAF96072     46 ---------aDLQRYQEPYEqsylntlmetve--------acrsqhhihkdEVPFPLMVEHSeqp-------------av 95  Vibrio cholerae ...
NP_279740    63 -------eygERRESMANIPdfdvtytidea---------tdgarkfasdiGRDVLSDVDIEptsvgr------vgdkgd 120 Halobacterium sp...
NP_440274   204 ---lleirrqEAEAKLAEIKq-----------------------------qFSPLVPNIITEvrhg----------spvq 241 Synechocystis sp...
ZP_00109960 657 ------eyilYEQRSLTPVKeiahdlleq--------------qaaigrnlGADVKTYILQGssp-------------er 703 Nostoc punctifor...
NP_866284    56 pkeleklvaeDHRRRLLNIAady-------------------------sdtGLSMDVVVAIGdp--------------at 96  Rhodopirellula b...
NP_968999   198 -----slfdlDTRPRIYNFKgqmltldqiiehtieeqshraqhwvdwahkeGVEAQFIIDNSfrg-------------vd 259 Bdellovibrio bac...
CAG23544     60 ldkatkvyhaELKQHVLNLKal---------------------------ysNVKFNTQIRTGip--------------fi 98  Photobacterium p...
ZP_00300638  57 lekeyekitrEAKADLDRILere-------------------------rsnGLPVAELIRKGep--------------tk 97  Geobacter metall...
CAG35472     49 -rissygykvDTEHYLETIRkd----------------------------rGAQIIELTEKLtlpdervsfsfrmgdptt 99  Desulfotalea psy...

Feature 1                       ## ##         ####              
1MJH_B      111 EIVKIAEDeg-vdIIIMGSHGktnlkeilLGSVTENVIkksnKPVLVV 157 Methanocaldococcus jannaschii
AAF96072     96 AIIKSALNhh-idLLIKEAEPmths-qqgFKALDMTLLrkcpCPVWLH 141 Vibrio cholerae O1 biovar eltor str. N16961
NP_279740   121 EILALADDrd-adHIFIAGRKrsptgkaiFGDVTQRIIlefdGAVTVI 167 Halobacterium sp. NRC-1
NP_440274   242 EILDTAFVnd-itAIAVASRRatll-dwtVPSLTDSILnrswFPLLFF 287 Synechocystis sp. PCC 6803
ZP_00109960 704 EILKFAQTqe-vdLIILGSSIrmvtgrvfFGHRVDAILskahCPVAVI 750 Nostoc punctiforme PCC 73102
NP_866284    97 EITRQVIHdd-hdLLIKTADGfsaa-grlFGSVAKSLLrlcpCPVWLL 142 Rhodopirellula baltica SH 1
NP_968999   260 ELVMEAIDsteadLVVMEAQSgpms-aalLGSYTRNVVrkahCPVYVL 306 Bdellovibrio bacteriovorus HD100
CAG23544     99 EIIKSAKEfq-skVIIIDSHRsnkeracqSGSTTRHLMrkseIPIWSI 145 Photobacterium profundum SS9
ZP_00300638  98 EILKAVEElk-idLLIMLSHEewrlehflFGRSNEEIVrkmpCSVLLV 144 Geobacter metallireducens GS-15
CAG35472    100 ELLKMIVEqe--iDMIVMGVKtrdftamfTGSVAERLFr--kCPITVV 143 Desulfotalea psychrophila LSv54

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