4UJ3,4UJ5


Conserved Protein Domain Family
Rab11BD_RAB3IP
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cd21068: Rab11BD_RAB3IP 
Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)
RAB3IP, also called Rabin-3, or SSX2-interacting protein, or Rabin8, acts as a guanine nucleotide exchange factor (GEF) which promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. It mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. It modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. The model corresponds to the Rab11a/Rab11b-binding region of RAB3IP lies within its carboxy-terminus, a region distinct from its GEF domain and Rab3a-binding region.
Links
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Statistics
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PSSM-Id: 411032
Aligned: 8 rows
Threshold Bit Score: 400.45
Created: 20-Dec-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Rab11 binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:Rab11 binding site [polypeptide binding site]
Evidence:
  • Structure:4UJ3; Homo sapiens RAB3IP (also called Rabin8) in complex with Rab11A and RAB11FIP3, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4UJ3_B         1 GAASNKSTSSAMsgshqDLSVIQPIVKDCKEADLSLYNEFRLWKDEPtMDRTCPFLDKIYQEDIFPCLTFsKSELASAVL 80  human
NP_001018417 231 GHVRNKSTSSAMlgsqqEVAVTQPIVRECKEVDSLLFTEFKAWKEEPtLERSCSFLERIYREDIYPCLTFsKSELGSAIL 310 zebrafish
NP_001080218 262 GHARNKSTSSAMgggtlDLSVLPPIVTESKEPDLSLYYEFRTWKEEPsMNRTCPFLHRIYQEDICPCLTFpKSELAAAVL 341 African clawed ...
XP_006006628  60 GHARNKSTSSAIgsnhaDLSAIQPIVKDCKEVDLLLFNEFKIWKEEPsMDRECPFLNRIYKEDIFPCLTFsKSELASAIL 139 coelacanth
XP_007901938 265 GHGRNKSTSAMLsn-sqELNVMQPIVRDCKEVDLLLFGEFKVWKEEPaMDRACCFLDRIYKEDIYPCLTFsKSELASTIL 343 elephant shark
Q96QF0       282 GHTRNKSTSSAMsgshqDLSVIQPIVKDCKEADLSLYNEFRLWKDEPtMDRTCPFLDKIYQEDIFPCLTFsKSELASAVL 361 human
4UJ5_C         1 GAASNKSTSSAMsgshqDLSVIQPIVKDCKEADLSLYNEFRLWKDEPtMDRTCPFLDKIYQEDIFPCLTFsKSELASAVL 80  human
PKK22873     235 GHARNKSTSSAMggshqDLTMMQPIVKDCKEADLSLYNEFRSWKDEPtMDRTCPFLDKIYREDIFPCLTFsKSELASAVL 314 rock pigeon

Feature 1             #######                                                       #  ##  #   # 
4UJ3_B        81 EAVENNTLSIEPVGLQpIRFVKASAVEC-GGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYI 159 human
NP_001018417 311 EAVEQNTLSVEPVGFQpLPVVRASAVEC-GGPKKCALCGQTKTCKHRIKFGDSSSYYYVSPFCRYRITSVCNFFTYIRYI 389 zebrafish
NP_001080218 342 EAVENNTLSIEPAGQQsVRFVKASAVEC-GGSKKCALSGQTKLCKHRIKLGDSSNYYYISPCCRYRIASVCNFFTYIRYI 420 African clawed ...
XP_006006628 140 EAVENNTLSIEPVGFQpLPVVKASAVDCsGGSRKCALSGQTKTCKHRIKLGDSSNYYYVSPFCRYRITSVCNFFTYIRYI 219 coelacanth
XP_007901938 344 EAVESNTLSIEPVGFQsLPVVKASAMEC-GGPKKCALSGQTKTCKHRIKLGDSSSYYYVSPFCRYRIMSVCNFFTYIRYI 422 elephant shark
Q96QF0       362 EAVENNTLSIEPVGLQpIRFVKASAVEC-GGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYI 440 human
4UJ5_C        81 EAVENNTLSIEPVGLQpIRFVKASAVEC-GGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYI 159 human
PKK22873     315 EAVENNTLSIEPVGLQpVRFVKASAVEC-GGPKKCALSGQSKSCKHRIKLGDSSSYYYISPFCRYRITSVCNFFTYIRYI 393 rock pigeon

Feature 1           #####                          
4UJ3_B       160 QQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 193 human
NP_001018417 390 LQGLVKQQDAEQMFWEVLQLRKEMSNAKLGFYKD 423 zebrafish
NP_001080218 421 HQGLLKQQDVDQMFWEVMQLRKEMSQAKLGYFKE 454 African clawed frog
XP_006006628 220 QQGLVKQQDAEQMFWEVVQLRKEMSLAKLGYYKE 253 coelacanth
XP_007901938 423 QQGLVKQQDVEQMFWEVMHLRKEMSLAKLGFYKE 456 elephant shark
Q96QF0       441 QQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 474 human
4UJ5_C       160 QQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKE 193 human
PKK22873     394 QQGLLKQQDVDQMFWEVMQLRREMSLAKLGFYKE 427 rock pigeon

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