Conserved Protein Domain Family
PT_UbiA_DGGGPS

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cd13961: PT_UbiA_DGGGPS 
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.
Statistics
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PSSM-Id: 260124
Aligned: 129 rows
Threshold Bit Score: 147.265
Created: 26-Feb-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative active
Feature 1: putative active site [active site], 4 residue positions
Conserved feature residue pattern:d d d dClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on homology modeling using structures of trans prenyltransferases that are helical enzymes containing two D-rich motifs in the active site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                      #   #             
YP_005920236   6 VFLEIMRPGNCLMAGIAALIGLMVADsgpl-------pvtAALVFIAVFAVTGAGNAVNDYFDREIDAVNRPGRPIPSKR 78  Methanosaeta ha...
EEG43537      15 AFFSVLRGYNIALIVLAQYLCSIFILapnkslkeiildphLALLVLSTAIVIGSGYIINSFYDAEKDLINRPRKTLLDRH 94  Flavobacteria b...
EJU34740      11 GLFSVVRGYNILMLCVAQYLTAIFILsrapikr-vlldgrLFAIVLSGALAVAGGYIINAFYDKEKDMINKPTRAMIERL 89  Capnocytophaga ...
YP_004740800  16 GLFSVVRGYNILTICVAQYLAAVFVFsknesfkevffndvLFMLVVAGAFAVAGGYIINSFYDYEKDLINNPFKSMIDRL 95  Capnocytophaga ...
EAR13177      15 SLFSAVRAYNILVLIIAQYLVAIFIFsptkslvkvvfdiqLLFVVLASVFVIAGGYIINNFYDVKADKINRPLKASFDNY 94  Polaribacter ir...
AGC77118      24 SLFSSVRLYNIVLVGFAQLLAAIFIIapelsvksilldyrLWMIIFATSAAIAGGYIINNFYDREKDLINRPQKTLLENK 103 Donghaeana dokd...
EEG41113      16 SLFSLVRGYNIIVLVLAQYLTARYILapqrswwslildydFFSIIIASSLTTSAGYIINNFYDAAKDQINRPKKYILEHL 95  Flavobacteria b...
AFL97217      15 ALFAVIRGYNVAILVLAMYFAAFFIFakgdslsqffrnveIHYIIISTALSVSAGYIINNFYDLDKDQIARPIMAYLAKF 94  Ornithobacteriu...
ADX67823      10 ALLNVVRVYNLMVLALAQYLAALFVFapnqshreiildpiFNAIVFASTLSAAAGYIINNFYDLEKDAIKRPLLAYLNRK 89  Weeksella viros...
ADQ81604      29 SLMLGARVFVLAFYVFTLYVSTFFLFnqeeslrvfvfdykVHGIIVCSMLSIAAGGLINQFYDKEKDQITKPFRSYFQSF 108 Riemerella anat...
Feature 1                                                                                        
YP_005920236  79 ISPerAFAWSILLf-lLGSAVAlLINPVAFAIAVAnsILLYLYARNLKVtpFFGNLAVGYLTGSTFLFGGAAgg-dvGIT 156 Methanosaeta ha...
EEG43537      95 ISQr-AKITAYFTgnfLAVFMAsAVSFRAVVFFSAyiFGIWLYSHKLKRmaFLGNVVSACLAITPFFTVFVYhknlaPVI 173 Flavobacteria b...
EJU34740      90 VGQntKLTLYFVLn-fLSVIVAsYVSFAAVLFFSIyiFMMWFYSHRLKKmvLVGNIISGILSIIPFFAIFVYyhnfqKVI 168 Capnocytophaga ...
YP_004740800  96 ISQntKLTAYFLLn-fFSIFVAgYVSFRAILFFSAyiFGMWIYSHRLKKipFVGNVTAALLAITPFFAIFLYyknfdLII 174 Capnocytophaga ...
EAR13177      95 VKQstKLKLYFLLn-fIGFSFGiLISLRASLFFASyiFAIWFYSHKLKKypFLGVISATVLTVLPFFAVFVYfgnfhKII 173 Polaribacter ir...
AGC77118     104 VRRstLWSVYFTVn-gIAFVLGsIVSWRAGLFFAFyiFAMWFYSHKLKRtlFLGNLMAALLAVTPFFVLFMYyknfyPVI 182 Donghaeana dokd...
EEG41113      96 ISQqhQMVLYLFLn-mFAFIFAsVISFRAVLFFLFymLAIWFYSYRIKRlfWLSNLYSALLMILPFWAITFYlknfeALV 174 Flavobacteria b...
AFL97217      95 VSQnfKLITYLFLn-sLALIFAfLASWRVAIFILVfqFLTWFYCHKLNKivFINNLSSTVLALFPFLALFLYfnnysAVI 173 Ornithobacteriu...
ADX67823      90 VSQgfKLRLYIFLn-sLALLLAfYVSWRVLLFFVGyqFLVWIYSHRINKivFLKNLFSVILRVFPFFALLLYfenyhLNV 168 Weeksella viros...
ADQ81604     109 VKEkyILYSYLLLn-vLSLGIAlVLSYRILIFFLVyqFLIWFYSHKLSRiaVVNNLTYVSLSLYPFFGLLVYyqhfsGLL 187 Riemerella anat...
Feature 1                             #   #                                                      
YP_005920236 157 LFLFLLATLATLAREVEKDIEDVPGDRasGARTLPIVIGERRAShLAASFVLIAILLSYLAPl-------GRAYLAAv-- 227 Methanosaeta ha...
EEG43537     174 FVQAIFLFLLVLARDMVKDLENLTGDLtqDYKTVAVTYGTRFSKyCVSILLVATVFPTYLLItkfn-vgyMDWYFKG--- 249 Flavobacteria b...
EJU34740     169 FVHAAFLYYLLLAKDFVKDLQNIKGDFalGYHTIATDYGERSSKqLISLLVGLTLLCVYFLTsfpd-tgaMKYYFILa-- 245 Capnocytophaga ...
YP_004740800 175 FVHAFLVFLLILIKDLTKDLRSLKGDLaqNYQTIAVKYGEKVSKiAISIAVLMCFIPIYALLthfd-vgnMKYYLAFt-- 251 Capnocytophaga ...
EAR13177     174 FVYASFLFLVIMVRQLIKDLQNIKGAIvnNYSTFPVVYGEKKTKeLALVVLLLTSIPIAILFsapa-esfVKYYFYF--- 249 Polaribacter ir...
AGC77118     183 LVHGGFLFLILGMRELVKDLENLRGDLaqNYRTIPVVMGEKVSKqFYTFLTFLTIVPITVLItyfe-ighMQYYFTL--- 258 Donghaeana dokd...
EEG41113     175 FYHAGFLFFLILGRDIIKDLENFRGDWvhRYKTLPVVFNDSITKwIATFCLMLSLFPSYFLIqhp--lglMYYYFAL--- 249 Flavobacteria b...
AFL97217     174 FVHGAFLGLNLLTLDIEKDFLTQRADSiyEYQTLPTVLGTRKAKlILNLLLLLTAVVAFLLAhfdg-vgnMSYYFYSvgv 252 Ornithobacteriu...
ADX67823     169 FVHAGFLTVLLMITDLLKDLSSQKADAiyGYNTLPIVYGEKRTKtILQLLSLSAICLAIFLVvsy--slgSMQYFFYa-c 245 Weeksella viros...
ADQ81604     188 FLMSVFLFVLLLIIDVIKDIVTRAADKlfGYATIPVLFGKTKTVyWLYLLLIINSLTSYLIVnklkyfnlVAYYFSVs-- 265 Riemerella anat...
Feature 1                                                
YP_005920236 228 TVADLLFLAALASilrg--eapRAQKMLKAGMAAALVAFM 265 Methanosaeta harundinacea 6Ac
EEG43537     250 VFVLLIAAIVGLWlakekkqylNIHNLLKFIIVGGVFGIL 289 Flavobacteria bacterium MS024-3C
EJU34740     246 AIVLLAVFTPILWrskteihyaFLHNLLKVIIVVGVFCIV 285 Capnocytophaga sp. CM59
YP_004740800 252 CVFLCFYIFFLWIsnkq-kqytLLHNLLKITLISGVFSIS 290 Capnocytophaga canimorsus Cc5
EAR13177     250 AIVVLLFVGFYLWqsktkkeyqILHNILKLLLLIGVLCLL 289 Polaribacter irgensii 23-P
AGC77118     259 ITGALLVCLPLIWssrrkreylLIHFILKVIIGAGVFSIL 298 Donghaeana dokdonensis DSW-6
EEG41113     250 SAPYLLLVLVLLWrakdqkmylWLHNLIKAWILIGVLSIA 289 Flavobacteria bacterium MS024-2A
AFL97217     253 VFFALPYFILKAKskk---ewhLLHFVLKILLWIGVLSLA 289 Ornithobacterium rhinotracheale DSM 15997
ADX67823     246 IFILLGFIFRIGRinsi-ryyqAMHLFFKAIIVTGVISII 284 Weeksella virosa DSM 16922
ADQ81604     266 ILVYLLVGISLYFfrys--kmsRLINALRVWVFIGVVFML 303 Riemerella anatipestifer RA-CH-2

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