P2 domain of macrophage-expressed gene 1 protein (MPEG1) and similar proteins
Macrophage-expressed gene 1 protein (MPEG1), also called perforin-2 (P-2) or macrophage gene 1 protein (Mpg-1), is a pore-forming, antibacterial protein with broad-spectrum activity. It is a major antibacterial effector protein of the innate immune system in phagocytic as well as tissue forming cells. It plays an essential role in intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria by inserting into the bacterial surface to form pores. This model corresponds to a unique membrane bound P2 domain of MPEG1, which helps to stabilize the pre-pore state by swapping between monomers and enables MPEG1 to bind its targeted membrane.
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