1NTG,1FL0,1NTG,1EUJ,1E7Z


Conserved Protein Domain Family
tRNA_bind_EMAP-II_like
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cd02799: tRNA_bind_EMAP-II_like 
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tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Links
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Statistics
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PSSM-Id: 239198
Aligned: 32 rows
Threshold Bit Score: 142.367
Created: 22-Jun-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative tRNA-binding site [nucleic acid binding site]
Evidence:
  • Comment:These residues were identified by mutational analysis as important for interaction with tRNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            #                      #                         #   #   
1NTG_A      5 VIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGe----------aEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMR 74  human
NP_702290 239 DDISRLNVLVGYVEQVEIHPDADTLYCLKINLGe----------dKPRDICSGLRNKKNAEDLLNKYVLVLANLKEKSLR 308 Plasmodium falcipa...
AAX70714   56 TSMSKCRFVVGRVNSVRPHPESQKLYIEEIDLGee--------ggKCRTILSGLQEYVKQEDFLNRLVLVIANLEPRKIG 127 Trypanosoma brucei
CAA10536  280 EPVSQLDIRIGKITKIWKHPESDNLYCEEIDIGd----------eKPRQIASGLQQFVPIEQMENALVLVLANLKPRKLG 349 Euplotes octocarin...
NP_915251 247 CNVSILNIQVGLIRKAWKHPSADSLLVEEIDLGd----------gNVHQVVSGLAKFFSPEELVNRHVVLITNVKPGKLR 316 Japanese rice
AAL15216  227 LSVSLLNIQVGLIRKAWKHPSADSLLVEEIDVGe----------dKVRQVVSGLAKFCSPEDLTNRLVALITNVKPGKLR 296 thale cress
EAN32410  198 DDVTRLNVVVGSVLSIRKHQDADKLYCLKVDIGt-----------EVRSICSGLVDFLGPDDILNKKVCILANLPKKNLR 266 Theileria parva
CAG86493   10 VPPSLLNIKVGKILQCQRHKNADKLYVSQIQIEenpiednenieaKIVQVCSGLVDFIPIEQMKDRKVAVLANLKASKQR 89  Debaryomyces hanse...
AAS53535   24 LPYSLADIRIGKVLSVREHPESYKMYITQVSFGg----------lGTKQICTGLRDHVPTSEMQDSLVVVLNNIKKCKLR 93  Ashbya gossypii AT...
EAA07816  379 NTPDKLELKVGQIMDAVKHPDADSLCVLTVDIGg----------gERKAIVSNLMAHYTLEQLRDRFVVVLTNMKASKIR 448 Anopheles gambiae ...

Feature 1        #  #                                     
1NTG_A     75 GVESQGMLLCASieg------inrQVEPLDPPAg--sAPGEHVF 110 human
NP_702290 309 GKKSHGMVLCGSfd---------eKVELLVPPNg--vKIGERIL 341 Plasmodium falciparum 3D7
AAX70714  128 GIPSEGMVLCAScnde-----gsrSVVLLDVPEg--tPVGERIL 164 Trypanosoma brucei
CAA10536  350 GFESQGMVLMAGnnd-------ytYFELPVIPEg--cKAGDLVT 384 Euplotes octocarinatus
NP_915251 317 DVMSAGLVLCASnqd-------htVVEPLIPPEg--aKPGERIS 351 Japanese rice
AAL15216  297 DVMSQGLVLCASsed-------hsVVEPLLPPAg--aKPGERVS 331 thale cress
EAN32410  267 GEESNGMVLCVSneg-------ksSVELLEPPEe--tPVGERVS 301 Theileria parva
CAG86493   90 GVKSEAMLLAVEksfgsdaelsdaKVELINPPRn--aKVGQKLY 131 Debaryomyces hansenii CBS767
AAS53535   94 GEVSEAMILCAEyspq----eskpSVQLLQPAIsspeFCGARVL 133 Ashbya gossypii ATCC 10895
EAA07816  449 GVESEGLVLYAAga---------eKCEALAVPEg--sKVGERII 481 Anopheles gambiae str. PEST

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