Conserved Protein Domain Family
AKR_AKR8A1-2

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cd19077: AKR_AKR8A1-2 
AKR8A family of aldo-keto reductase (AKR)
Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Statistics
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PSSM-Id: 381303
Aligned: 27 rows
Threshold Bit Score: 309.94
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ###                                         #    #                    
Q06494      8 NNIHKLDTGYGLMSLTWrae-------piPQSQAFEAMHRVVELSRerghkAFFNVGEFYGpd---fiNLSYVHDFFAKY 77  baker's yeast
GAC75470   11 GAQELGPFGLGLSLYSPwaalykhvptaeQDEASMATILAAVERGV-----RLLDSATYYGhd---hhGLKLLAKVIKRV 82  Pseudozyma antarct...
GAM86996    4 MPIPLPTNGFGLMRKVV------------PDERAFPVLATAIRQGA-----TVWSIATHYGtpd--enSLHLMKRYFSAR 64  fungal sp. No.11243
KIR84022   10 AGKQVSRMGYGLMQLTWnpq-------ppSQDVSFAAMKAAADFGS-----TIWSSAAFYGnpgdnfaNIKLIAAFFDKY 77  Cryptococcus gatti...
CNE06205    9 DGPAVSTLGLGAMGMSGayg-------etDRAESIATVHAALDAGV-----TLIDTADFYGmg----hNELLLAEALRGR 72  Mycobacterium tube...
KPL81716    9 DGLVVSVAGLGCMAMSGmyg-------psDRAESIATIHAALDAGI-----NLLDTGDFYGig----hNELLISEALRER 72  Herpetosiphon geys...
KZZ92707    5 LGQEVGEIGYGLMHFTWaas-------ppSPEKYTEPMRTALARGS-----NYWNGGELYGppe--fnSLHMLRDYFRAH 70  Ascosphaera apis A...
OBR85492   13 AGKPTIRMGLGLMGLTAgrd------epvSDQVAFEVIKKSLDAGA-----NLLNTAMFYGghsdplsNLKLLGRFFAQY 81  Cryptococcus dejec...
OCL06440    5 CGKEVGPVGYGMHTLTRrgf-------alEVEEGISILKATFDAGY-----RFWNGGMHYGtpe--ynSLHLLNAYFTKY 70  Glonium stellatum
POE71345   23 GVPLQRSTGYGLMGLTWran-------ppSQEQAFAAMKAALGQGA-----NFWNGGEIYGsak--rnSLHLLREYFTQY 88  Quercus suber
Feature 1                #                                           ##                       
Q06494     78 PdlrKDVVISCKGGAdnatl----tprgsHDDVVQSVKNSVSAIg--GYIDIFEVARIDtslctkgevypYESFEALAEM 151 baker's yeast
GAC75470   83 Gr--EKLVLSVKFGGkitgkg--mehhvgRKDVRREIETTLAVLg-vEYVDIFVPARVTpet------piEETVDELKAL 151 Pseudozyma antarct...
GAM86996   65 PedaPKVTLCLRAGVvsidk-----mdcsPANMRRSLEVALDILggtKSIDLYGPGRVDpnv------aiEHTVREVARL 133 fungal sp. No.11243
KIR84022   78 PeykSKIVLVVKGGAdyadlh---prgteLDFLRTELKEMKRILg-dKEIDVYSLARLPeg-------svEETFKGLDAL 146 Cryptococcus gatti...
CNE06205   73 Pr--DGYELSVKFGMlrgpgpefggidgrPEAVKNYLAYSLARLg-tDHIDVYRPARLDpav------piEETVGAIKEM 143 Mycobacterium tube...
KPL81716   73 Sr--TDVVLSVKFGAmrgpdgswlgydsrPAAVKNSLAHTLTRLn-tDYIDIYRPSRLDpav------piEETIGAIAEM 143 Herpetosiphon geys...
KZZ92707   71 PedaDKVVLNIKGGLipgtl----tpdgsKANIDRSINECLRVLdgtKALDVFEAARVDpnh------piEETIGYLAEH 140 Ascosphaera apis A...
OBR85492   82 PeyrDKAIVSVKGGMigkfs----ectgdYDHLKKEILVAKDLLq-gKEIDIFAPARLPddr------plEETIANLLKL 150 Cryptococcus dejec...
OCL06440   71 PedaDAVVISIKGAWdstaf----ipyctPEGLMDSVETCLRILdgkKKIDIFEPTRLDkqi------piEAVVEVLGAL 140 Glonium stellatum
POE71345   89 PgdaSKVVISIKGGCqydsm----vpdggTENTRRSIQECIDVLggtKKLDIWEAARVDpkt------piEVTMRAAKEF 158 Quercus suber
Feature 1                ##                    #                             #######          
Q06494    152 ISEGVIGGISLSEVnEEQIRAIHKdwgkFLTCVEVELSLFSNDil-hNGIAKTCAELgLSIICYSPLGRGLLTGQLKSna 230 baker's yeast
GAC75470  152 VQEGKIRAIGLSEAsAASIARASAv--hPIACLQTEFGPMETSie-qNGILEACRKNnVLVLAYGVVQHGFLSDKGLSpw 228 Pseudozyma antarct...
GAM86996  134 VAQGLVKGIVLSEVsAATIRRAAAv--hSIAAVETEVSLWAREvf-dNGVASTCKELgIPILAYSPLGRGMLAGNFANld 210 fungal sp. No.11243
KIR84022  147 KKEGLFGGVGASEMsAPSLEKAHKi--tPIAINEIEISLFSYDkp-iRDAIEWHDTNkIPVFAYSPLGRGFITRTYKSpd 223 Cryptococcus gatti...
CNE06205  144 IDAGHVRHLGLSEVdAETIRRAHAv--hPVADLQIEYSVIFREv--eADVLPTLRELgIGLTAYGVLGRGLISGHWSPgh 219 Mycobacterium tube...
KPL81716  144 IEKGYVRHIGLSEVgVETIRRAAAv--hPIVDLQIEYSLMSRGi--eAEILPTCRELgIGITAYGVLSRGLLSGAWSKer 219 Herpetosiphon geys...
KZZ92707  141 VKAGNIKGIGLSHVdAETIRRAHKv--hPIASVEVMLHLGNRTil-kNGVTATCKELgIPILAYSPLGSGVLIGKVKSls 217 Ascosphaera apis A...
OBR85492  151 QKEGLFRTIGLSEVsHQSLRRAYQlsngQISSNEIEVSLQTLGdaelVETVRTCSELgIKVIGYSPFGHGFLSGTLKDls 230 Cryptococcus dejec...
OCL06440  141 AQSGDIGGVGLTEVnHETIKRAHAv--yPIAAVEIELSLFSTEvl-tNGIVKTCNELgIPVVAYAPFARGWLTGGLKSrg 217 Glonium stellatum
POE71345  159 IDAGTLGGVSLSECsEDTIRRAAKv--lKPVAVEVEFSLWSTEiv-dNGITAACKELdIPIVAYSPLGRGFLTGQVKSld 235 Quercus suber
Feature 1                                                     #                       ######  
Q06494    231 di-pegdFRKSLKRF--SDESLKKNLTLVRFLQEEIVDKRpqnnsiTLAQLALGWVKHWnkvpeysgaKFIPIPSGSSIS 307 baker's yeast
GAC75470  229 defrdaaSRAFYPRF--HKENYEHNQGLLRQLQRFIEQRQln---iSISALAVAWVMRRggyatetdaRIMPLLGMRTTR 303 Pseudozyma antarct...
GAM86996  211 dv-angeFHSMYPRF--QAGQFEQNLELVRAVQKLATQKGc-----TSAQLALAWLRYKgget--gmpAIIPVPGARSQE 280 fungal sp. No.11243
KIR84022  224 di-pegdFKRYLPRF--QGQAFYENLKLVDKLDEIAARKGv-----NGSQVALAWILSLs-------nYIIPIPGSSNTK 288 Cryptococcus gatti...
CNE06205  220 ts-gpgdGRGSSPRF--SGGNVEHNLALVDALRRIAEAKGc-----TVAQLVIAWVAAQg-------dDIVPLVGARTRK 284 Mycobacterium tube...
KPL81716  220 vl-agsdFRAHGPRF--TGENLDRNLDLVAALQTIADAKGa-----SIAQIASAWVAAQg-------aDIIPLFGARRLH 284 Herpetosiphon geys...
KZZ92707  218 -----dlPEGDVRRFltDDEKLRATKAFVQRITEVAEKKGl-----TPAQLSLTWIRTLssqd--dmpTIIPIPGSTNVS 285 Ascosphaera apis A...
OBR85492  231 gigktdwRNILPRLS--DKDNFETNLVLVNEIQELARRQGke---rSMPELILGSLLRFd-------eCIIPLPGSIDPK 298 Cryptococcus dejec...
OCL06440  218 ql-kegdWRLKLARF--NDEVWQANQAVVDALMKITERKGc-----GINELALAWVVKT---------GALPIPGSGRKE 280 Glonium stellatum
POE71345  236 di-paddFRRSIPRF--SEENFPKNLELVKEVERLAEKKGc-----KPGQIGMAWIKAKsgte--glpTIVPIPGATTAE 305 Quercus suber
Feature 1     #  ##                   
Q06494    308 KVNENFDeq--kTKLTDQEFNAIN 329 baker's yeast
GAC75470  304 SLQDNIKaakfaSLMSQHDADALE 327 Pseudozyma antarctica T-34
GAM86996  281 RVEENYGp----IVLSPAEMDRIQ 300 fungal sp. No.11243
KIR84022  289 RVAENIQsa--nVKLTSEEKKEIN 310 Cryptococcus gattii IND107
CNE06205  285 RLAEALPaa--dLDLTADDLAEID 306 Mycobacterium tuberculosis
KPL81716  285 QLHDSLAsl--eIGLNADELASIE 306 Herpetosiphon geysericola
KZZ92707  286 RVIENTEl---lPLLTAEDMAEIE 306 Ascosphaera apis ARSEF 7405
OBR85492  299 KAAQNAKaa--nTQLTDEEMKEVM 320 Cryptococcus dejecticola CBS 10117
OCL06440  281 GIKANMEaa--qLKLTDEDCEAID 302 Glonium stellatum
POE71345  306 RIEENMVd----VELSSNDVKEID 325 Quercus suber

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