1YRL


Conserved Protein Domain Family
ilvC

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TIGR00465: ilvC 
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ketol-acid reductoisomerase
This is the second enzyme in the parallel isoleucine-valine biosynthetic pathway [Amino acid biosynthesis, Pyruvate family]
Statistics
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PSSM-Id: 273093
Aligned: 10 rows
Threshold Bit Score: 443.358
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YRL_A        35 LQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEaiaekrASWRKATEN----GFKVGTYEELIPQADLVINLTPDK- 109 Escherichia col...
P37253        15 LAGKTVAVIGYGSQGHAHALNLKESGVDVIVGVRQG------KSFTQAQED----GHKVFSVKEAAAQAEIIMVLLPDEq 84  Bacillus subtil...
O27491        14 LADKKIAVIGYGSQGEAQARNMADSGLNVIVGLRRGg-----SSWKKAHDD----GMNVMTIEDASREADIIHILIPDEi 84  Methanothermoba...
O25097        16 IQSLQVGIIGYGAQGEAQALNLRDSKVKARIGLYQGs-----LSVSKAKKE----GFEVLEVKELVQNSDVIMALLPDEl 86  Helicobacter py...
P06168        75 FKNDTFALIGYGSQGYGQGLNLRDNGLNVIIGVRKDg-----ASWKAAIEDgwvpGKNLFTVEDAIKRGSYVMNLLSDAa 149 Saccharomyces c...
Q58938        15 VKDKTIAVIGYGSQGRAQALNMKDSGLNVIVGLRPNg-----ASWNKAIKD----GHKVMTIEEAAEKADIIHILIPDEv 85  Methanocaldococ...
WP_010874148  51 LAGKTVAIIGYGSQGHAHALNLKDSGVNVVVGLYSGs-----KSVAKAEGA----GLKVLSVAEAAKAADLIMILLPDEv 121 Synechocystis s...
WP_000956955  80 LQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEaiaekrASWRKATEN----GFKVGTYEELIPQADLVINLTPDK- 154 Escherichia
WP_005644201  35 LKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEaiaekrASFQRATEN----GFKVGTYEELIPTADLVVNLTPDK- 109 Haemophilus hae...
O28294        15 LDGKTVCIIGYGSQGHAHALNLKDSGVNVVVGLPEWd----kATWERAEKD----GMVVKKLSEAADGADVIAMLIPDMv 86  Archaeoglobus f...
1YRL_A       110 QHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQ---IRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPenD--PK 184 Escherichia col...
P37253        85 QQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIV---PPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQ--D--VT 157 Bacillus subtil...
O27491        85 QETVFEQSIRPYLKEGNTISFSHGYNIHYGYIK---APEGVNVTMVAPKGPGAMVRRTYLEGFGIPGLVAVEV--D--AT 157 Methanothermoba...
O25097        87 HKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVV---LPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQ--Es-SI 160 Helicobacter py...
P06168       150 QSETWPA-IKPLLTKGKTLYFSHGFSPVFKDLThvePPKDLDVILVAPKGSGRTVRSLFKEGRGINSSYAVWN--D--VT 224 Saccharomyces c...
Q58938        86 QPAVYKKQIEPYLTEGKTISFSHGYNIHYGFIR---PPENVNITMVAPKSPGAMVRKTYEEGFGVPGLVAVER--D--YT 158 Methanocaldococ...
WP_010874148 122 QKTVYEAEIAPNLVAGNVLLFAHGFNINFAQIV---PPADVDVVMAAPKGPGHLVRRTYEQGQGVPALFAVYQ--D--AS 194 Synechocystis s...
WP_000956955 155 QHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQ---IRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPenD--PK 229 Escherichia
WP_005644201 110 QHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEE---IRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHP--EndPK 184 Haemophilus hae...
O28294        87 QPAVYREHIQDKLKEGAMLMFAHGFNIHYNQIV---PPEYVDVAMVAPKGPGPLVRRMYVEGKGVPSLVAVEQ--N--YT 159 Archaeoglobus f...
1YRL_A       185 GEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGW-ETITE 263 Escherichia col...
P37253       158 GEARDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGYQPELAYFECLHEL-KLIVD 236 Bacillus subtil...
O27491       158 GDAMEQALAMAKACGLARAGVLETTFREETETDLFGEQAVLCGGVTELINTAFKTLVRAGYQPEIAYFETCHEL-KLIVD 236 Methanothermoba...
O25097       161 HNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIVRMGFETLIKAGYPEELAYFECVHEV-KLVAD 239 Helicobacter py...
P06168       225 GKAHEKAQALAVAIGSG--YVYQTTFEREVNSDLYGERGCLMGGIHGMFLAQYDVLRENGHSPSEAFNETVEEAtQSLYP 302 Saccharomyces c...
Q58938       159 GDALQIALGMAKGIGLTKVGVIQTTFREETETDLFGEQVVLCGGVTELIKAAFETLVEAGYAPEMAYFETCHEL-KLIVD 237 Methanocaldococ...
WP_010874148 195 GQARDYAMAYAKGIGGTRAGILETTFREETETDLFGEQVVLCGGLTALIKAGFDTLVEAGYQPELAYFECLHEV-KLIVD 273 Synechocystis s...
WP_000956955 230 GEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGW-ETITE 308 Escherichia
WP_005644201 185 GEGMAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGW-ETITE 263 Haemophilus hae...
O28294       160 GKALEVALAYAKGIGATRAGVIETTFKEETETDLFGEQVDLCGGVAEMIKMSFETLVEAGYQPEIAYFEVLHEL-KLIVD 238 Archaeoglobus f...
1YRL_A       264 ALKQGGITLMMDRLSNPAKLRAYALS-EQLKEIMAPLFQKHMDDIISGEFSSgmmaDWANDDkklltwreETGKTAFETA 342 Escherichia col...
P37253       237 LMYEEGLAGMRYSISDTAQWGDFVSGpRVVDAKVKESMKEVLKDIQNGTFAK----EWIVEN--------QVNRPRFNAI 304 Bacillus subtil...
O27491       237 LIYERGFRGMWHNVSNTAEFGGLTRRgRIITEETEKEMDEILKEIQNGKFAK----EWALEN--------RAGAPMLKRM 304 Methanothermoba...
O25097       240 LLHYKGVEGLRKHISNTAEFGAIKAR-EPMGKLLKKRMQKILKKIQNGSFAK----DFLLEK--------SLNYPRLNTE 306 Helicobacter py...
P06168       303 LIGKYGMDYMYDACSTTARRGALDWY-PIFKNALKPVFQDLYESTKNGTETK-----RSLEF---------NSQPDYREK 367 Saccharomyces c...
Q58938       238 LIYQKGLQGMWENVSNTAEYGGLTRRaRVINEESRKAMKEILKEIQDGRFAK----EWSLER--------EAGFPHLNAL 305 Methanocaldococ...
WP_010874148 274 LIVEGGLAKMRDSISNTAEYGDLTRGpRIVTEETKAEMRQILDEIQSGQFAR----EFVLEN--------QAGKPGFTAM 341 Synechocystis s...
WP_000956955 309 ALKQGGITLMMDRLSNPAKLRAYALS-EQLKEIMAPLFQKHMDDIISGEFSSgmmaDWANDDkklltwreETGKTAFETA 387 Escherichia
WP_005644201 264 ALKQGGITLMMDRLSNSAKLRAFELA-EQIKESLGFLYYKHMDDIISGHFSAtmmaDWANGDkdlfawreATGKTAFENA 342 Haemophilus hae...
O28294       239 LIYEGGIYNMWSAVSETAKYGGMTRGkRIFTEQTREEMRKILKEIQTGEFAR----EWILEN--------MAGRPVYNKL 306 Archaeoglobus f...
1YRL_A       343 PQYEgk-iGEQEYFDKGVLMIAMVKAGV 369 Escherichia coli BW2952
P37253       305 NASE----NEHQIEVVGRKLREMMPFVK 328 Bacillus subtilis subsp. subtilis str. 168
O27491       305 RKLE----SELEIEEVGSKLRKLCGLEK 328 Methanothermobacter thermautotrophicus str. Delta H
O25097       307 RKAL----KETKIEQIGEILRAPFNHKK 330 Helicobacter pylori 26695
P06168       368 LEKEldtiRNMEIWKVGKEVRKLRPENQ 395 Saccharomyces cerevisiae S288c
Q58938       306 RRLE----KEHLIEKVGKELRKMCGLEK 329 Methanocaldococcus jannaschii DSM 2661
WP_010874148 342 RRRE----SEELIEEVGKDLRAMFSWLK 365 Synechocystis sp. PCC 6803
WP_000956955 388 PQYEgk-iGEQEYFDKGVLMIAMVKAGV 414 Escherichia
WP_005644201 343 PKYDgk-iSEQEYFDNGVLMIAMVKAGV 369 Haemophilus haemolyticus
O28294       307 LQME----REHPIEKIGKELRAMMPWLK 330 Archaeoglobus fulgidus DSM 4304
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