Conserved Protein Domain Family
DUF2235

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pfam09994: DUF2235 
Uncharacterized alpha/beta hydrolase domain (DUF2235)
This domain, found in various hypothetical bacterial proteins, has no known function.
Statistics
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PSSM-Id: 462937
Aligned: 306 rows
Threshold Bit Score: 69.1605
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KLU90879         65 RKLVLCFDGTGNKFRGD--D--------SDSNILKIFRMLDRTA-SD---------Q---YHYYQPGIGtyvvsnnlsah 121 
ENH79334          8 RRIIVCVDGTWYNADGKegYgk-----gNNSNVFRIFASVRPGLvTDgegk--qaeQ---IVKYFPGIG----------- 66  
Q0U1K9           68 KRLVVCVDGTWGCPDGTagSpe-----gNISTVYRVYASVKEGYvTDkatgkrwdqQ----RVYFNGLG----------- 127  Parastagono...
XP_007929914     41 RRFVICVDGASYKPDANs----------iPTNIYRIYTSIKNGKcVDrdtgityhqE----PLYYAGIGga--------- 97  
ELS:G432_12230   10 KNIVIFSDGTGQDGGVRpeQ--------RLSNIYKMYRAARPGPdSQidp----rlQ---VAFYDPGLGtdtsa------ 68  
WP_015934059      3 KNIVVFSDGTGQDGGVRpeQ--------RVSNVYKMYRVCKVGPeSGidp----aeQ---VAFYDPGLGtdiga------ 61   Methylobact...
Q11MJ3            3 KNIVIFSDGTGQEGGIRveQ--------RLSNIYKMYRVCRVSPeTNinp----reQ---VAFYDPGLGtetta------ 61   Chelativora...
WP_013834157      3 KNILIFSDGTGQYGGIRpdQ--------RLSNIYKMYRAMRPGTqTGisp----aeQ---VAYYDPGLGsgel------- 60   Novosphingo...
Q12DA6            3 KNIIIFSDGTGQAGGLKpdQ--------NLSNIYKLFRAARPGPeSPinp----aeQ---IAFYDAGLGtetdeg----- 62   Polaromonas...
Q0K247           44 ihINLFFDGTNNNDDVRtpArwrdstykTHTNVARLFRACPTRP------------QqgiFSSYIAGVGtlfpelg---- 107  Cupriavidus...
KLU90879        122 tsmrarFKSWMTKAK---DSAIGSSFDQHVVGGYRFLMRFY----SPG-DE----------------------------- 164 
ENH79334         67 --------VDRRPLNkfnDGITGDGCTQQIEDVYRASDNEV----KSSeDE----------------------------- 105 
Q0U1K9          128 --------NKLNALKnlhSGAFGSGLPDEIRKVYEYCCRETd---GPD-DE----------------------------- 166  Parastagono...
XP_007929914     98 -----dDVLSKDRLQ---AGVLGNPYQDQIRNIYEKCCELS----GPH-DE----------------------------- 135 
ELS:G432_12230   69 -tgitsIRRGITKLL---SSVTGRGITTNIADCYEFIVNHY----TPG-DR----------------------------- 110 
WP_015934059     62 -taltaPVRFVQKMA---ASVSGRGITTNIADCYRFIIDHY----EPG-DR----------------------------- 103  Methylobact...
Q11MJ3           62 -tgftsVVRWVQKTL---ASVSGRGITTNIVDCYEFLINHY----EPG-DR----------------------------- 103  Chelativora...
WP_013834157     61 ---ggrL----RNIL---ASAFGTGISENIVDCYEAIIKNY----EDG-DR----------------------------- 96   Novosphingo...
Q12DA6           63 -kipfrPVQKFRKIW---SAATGTGISRNIADCYEAILKHY----EPG-DR----------------------------- 104  Polaromonas...
Q0K247          108 ehtyssS-----------GKAFASGFAKRCAWGYTRVLNAVyqamVPG-DEnglikddeaakicakldwnlgsslltake 175  Cupriavidus...
KLU90879        165 ------------------------IYIFGFSRGAYIARFLA----EMLDYVGLL----S--HGNEEMVAF---------- 200 
ENH79334        106 ------------------------VWLYGFSRGAYVVRAVA----TLLHAHTLnskvaSssSDKS--------------- 142 
Q0U1K9          167 ------------------------IYFFGFSRGAFTVRAVA----NLLCYMHV--------PKGSQKFSKeefterykel 210  Parastagono...
XP_007929914    136 ------------------------AVFFGFSRGAYVVRAVA----GLLHRFGAL-------------------------- 161 
ELS:G432_12230  111 ------------------------IWLFGFSRGAYTARCIA----NVLMLCGV-----PtkVP-EGELPRfrlrvreisg 156 
WP_015934059    104 ------------------------IYLIGFSRGAYTVRCVA----NLLMYCGV-----PtkGA-GGPLLRfckmtrdiar 149  Methylobact...
Q11MJ3          104 ------------------------IFLFGFSRGAYTVRSVA----NLLMLCGI-----PsrDG-DQPLARfrkavrdias 149  Chelativora...
WP_013834157     97 ------------------------VFIFGFSRGAYTARCIA----NVMNLCGV-----PrsGENGNPLPAggialrkiae 143  Novosphingo...
Q12DA6          105 ------------------------VFLFGFSRGAYTARCVG----GVMSLCGV-----PthAADGSPLPRfgkglrriad 151  Polaromonas...
Q0K247          176 khlgslydslvrqckrnrlvrkayVNVFGFSRGAAGARVFVskliNYWAKAGKL-------AGKI--------------- 233  Cupriavidus...
KLU90879        201 --AWKAFAQWQC-------RRGKLREESRKKteel----------yeflKGFRETFSRPVRRIRFLGLFDTVNSVPRFET 261 
ENH79334        143 --VWKR-------------VTRLGPRKNSSDkyst----------ggekYRFALENTQESPVVKFLGLFDTVKK------ 191 
Q0U1K9          211 leLYPGVRASDRniwgqihSHFNR--------------------------------STRPPTIRFIGAFDTVKK------ 252  Parastagono...
XP_007929914    162 ------ISAGSPefgrnykKLLKDLGHPSLSstsnlslahvradsvssiSTITTQELRPSPNIRFLGVFDTIKA------ 229 
ELS:G432_12230  157 raVIRVYEHGAGh------DRAKYEEERDELarr------------frhDFGSDAGGEANVAPYFVGVFDTVASLGAKGP 218 
WP_015934059    150 eaVETVLEHGAGh------PRKDFDAERHELarrfr---------akygSDHDDGDGKSNVEPYFIGTFDTVAALGVAGP 214  Methylobact...
Q11MJ3          150 saVHNVLEHGAGh------PRAKFEDERLELarrfr--------arygaDHESGEPHRSNASPYFIGVFDTVAALGVKGP 215  Chelativora...
WP_013834157    144 eaVYKVYEHGSGh------SRAEYETEREELarrfre-------kygsrGTGYSGEAQGNVAPAFVGVFDTVAALGTVIV 210  Novosphingo...
Q12DA6          152 eaVSQVYEHGSGs------NKPERKEERLEKarrf-----------rekYGSQNDAGQSNVVPYFIGVFDTVAALGAPGP 214  Polaromonas...
Q0K247          234 --DYE---------------------------------------------------------VNFLGLFDTVASVGPP-- 252  Cupriavidus...
KLU90879        262 AWMERA------------------------------------------------------------------------VS 269 
ENH79334            --------------------------------------------------------------------------------     
Q0U1K9              --------------------------------------------------------------------------------      Parastagono...
XP_007929914        --------------------------------------------------------------------------------     
ELS:G432_12230  219 LRIALAalvallvaaaaatlagvahwafgirwtwsf-------------laaaaviggwtlwgylrtalkimwpplpgRR 285 
WP_015934059    215 KRTLIKaglaaavviplaiviavtsavvggisylfdgpfwqadlitsgvlvvasaavafavrrhlvaaktktitdwpsPG 294  Methylobact...
Q11MJ3          216 LAIGIKiflaagaallaaalafvpavvvagvlsffgfafwc---smlalvglaavaggvlitwqqrrsirkvirdfphPG 292  Chelativora...
WP_013834157    211 RRILGLlfvvslalvasawgfdwaepwkllah--------------------vpagfflisllwaskkqfkyirnppqGG 270  Novosphingo...
Q12DA6          215 RRLLMGlslvafvglttaaaagivslmpwfsfwpa--------------fsaftaaialallagyvntsvktirdfpkKG 280  Polaromonas...
Q0K247          253 ---ESFq----------------------------------------------------------------------sAV 259  Cupriavidus...
KLU90879        270 KFPYT-A------------RTSAKVIRHAVSIDERRAKFRQDLIYQSK--HESMerkkaaaeakakehgglhqarhmihe 334 
ENH79334        192 ---FSdNdefd-----ishVSSIQHVRHAMALNEDQQPMSVVSYDSRVdgTPVQ-------------------------- 237 
Q0U1K9          253 ---FTdNglyd-----vmpHSQIHHYRHALALNEERDEFKPETMMPDNdaCSP--------------------------- 297  Parastagono...
XP_007929914    230 ----VdDshfd-----isfNSSIKHFRHALALHEDRRALQPEEVHP----PEFYgte----------------------- 273 
ELS:G432_12230  286 WPSMHlAqwsgrn-fdrllSRSVLYARHAIAIDENRADFPRLKWGWGKgvERPPev------------------------ 340 
WP_015934059    295 EKRSHvAewkgen-fdrllSAQVGYARAAIAIDERRKDFDRVKWGPTEtpPPRAp------------------------- 348  Methylobact...
Q11MJ3          293 DKSSHlAewkgeh-fdrllSRFVGYARSANAIDETREDFARVGWG-----PTREmpe----------------------- 343  Chelativora...
WP_013834157    271 RLSWHfAawnlkn-ydrflDSSVGYARHALSIDENRKRFPRVGWGLRKdtDEQDr------------------------- 324  Novosphingo...
Q12DA6          281 NFSWHiAawrfrf-ydnslNTRVRYARHALAIDETRKDFARVPWATLGewPARP-------------------------- 333  Polaromonas...
Q0K247          260 DLEYFdGhfwaagggalniPAQVRRCVHFFSMHEQRMSFPLDSIRKGKsyPAG--------------------------- 312  Cupriavidus...
KLU90879        335 lhekyrvhhthhrlqqtpvfvdpkpevegqgqghgektngksagapqpaqdrgrrqsrqaaaahppprasldhaeryrah 414 
ENH79334            --------------------------------------------------------------------------------     
Q0U1K9              --------------------------------------------------------------------------------      Parastagono...
XP_007929914        --------------------------------------------------------------------------------     
ELS:G432_12230      --------------------------------------------------------------------------------     
WP_015934059        --------------------------------------------------------------------------------      Methylobact...
Q11MJ3              --------------------------------------------------------------------------------      Chelativora...
WP_013834157        --------------------------------------------------------------------------------      Novosphingo...
Q12DA6              --------------------------------------------------------------------------------      Polaromonas...
Q0K247              --------------------------------------------------------------------------------      Cupriavidus...
KLU90879        415 hsrsksrathrtrdssvaaavaarrlsgaghhaghehpdrlevpggdnddddedrdlahmpeasdvddgfsssdEDDQDI 494 
ENH79334        238 ---------------------------------------------------------------------------EGKRF 242 
Q0U1K9          298 ----------------------------------------------------------------------------GRSG 301  Parastagono...
XP_007929914    274 ------------------------------------------------------------------------lrHFGRSF 281 
ELS:G432_12230  341 -------------------------------------------------------------------------eGEAKPF 347 
WP_015934059    349 --------------------------------------------------------------------------GAPDQF 354  Methylobact...
Q11MJ3          344 ------------------------------------------------------------------------erNGVRTF 351  Chelativora...
WP_013834157    325 --------------------------------------------------------------------------GDLAWL 330  Novosphingo...
Q12DA6          334 --------------------------------------------------------------------------GEPEWL 339  Polaromonas...
Q0K247          313 ----------------------------------------------------------------------------DSKL 316  Cupriavidus...
KLU90879        495 DEVWFSGGHGDVGGGW-DIEPgg------ksASHVPLAWMVRE 530 
ENH79334        243 LQAWFVGAHADMGGGArDDG-----------LSLYPLQWMLNE 274 
Q0U1K9          302 LQAWFIGTHRDLGGANsKDG-----------LSLYPLQWVLSE 333  Parastagonospora nodorum SN15
XP_007929914    282 VQALFIGSHGDM-GGVsEKAG----------LGLYPLQWMILE 313 
ELS:G432_12230  348 IQLWFAGNHSDIGGSYpESESr---------LSDISLQWMLEE 381 
WP_015934059    355 RQFWFAGNHSDIGGSYdETESr---------LSDIALKWMLEQ 388  Methylobacterium nodulans
Q11MJ3          352 KQLWFAGNHSDIGGSYpESESr---------LSDIALQWMIEE 385  Chelativorans sp. BNC1
WP_013834157    331 KQVWFAGNHSDIGGSYpENESr---------LSDISLQWMLDE 364  Novosphingobium sp. PP1Y
Q12DA6          340 QQVWFAGNHSDIGGSYaEDESr---------LSDITLQWMAEQ 373  Polaromonas sp. JS666
Q0K247          317 LEVPYPGVHSDVGGSYaPGDQgksvkgeghrLGKIPLHDMYIE 359  Cupriavidus necator H16
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