Conserved Protein Domain Family
AKR_AKR3A1-2
?
cd19117: AKR_AKR3A1-2 
AKR3A family of aldo-keto reductase (AKR)
Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Links
?
Statistics
?
PSSM-Id: 381343
Aligned: 6 rows
Threshold Bit Score: 485.079
Created: 17-Apr-2018
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                        ###                      #   ##                              
P14065      7 DSTKILSLNTGAQIPQIGLGTWqskendaYKAVLTALKDGYRHIDTAAIYr------NEDQVGQAIKDSGVPREEIFVTT 80  baker's yeast
Q12458      7 NSSATLKLNTGASIPVLGFGTWrsvdnngYHSVIAALKAGYRHIDAAAIYl------NEEEVGRAIKDSGVPREEIFITT 80  Saccharomyces cere...
CCJ30068  315 FSNYINQLNNDTYIPALGLGTWqskpdeaALAVEIALKAGYRHIGIIRNSdtafmylNEEGVGQGIRNSGIPRNEIFVTT 394 Pneumocystis jirov...
POE49354   72 WTKQTFTLNTGDKIPAVGLGTWqsapnevRKAVAAALKAGYRHIDTALAYg------NEHEVGQGIKDSGVPREQIWITT 145 Quercus suber
CCF54161    9 PGQKTFKLNTGAEIPVVGLGTWqsapgevAKAVESAIKSGYRHIDAAWIYg------NENEVGQGIRASGVPRSELFITT 82  Ustilago hordei
EAA27685   30 PLSKTHKLNTGDEIPAVGLGTWqskpgqvEKAVEAALRAGYTHIDTAYAYg------NEKEVGQGIKASGVPREKIWLTT 103 Neurospora crassa ...

Feature 1     #                              ##                                               
P14065     81 KLWctqHHEPEVALDQSLKRLglDYVDLYLMHWParldpayiknedilsvptkkdgsravditnWNFIKTWELMQELPKT 160 baker's yeast
Q12458     81 KLWgteQRDPEAALNKSLKRLglDYVDLYLMHWPvplktdrvtdgnvlciptledgtvdidtkeWNFIKTWELMQELPKT 160 Saccharomyces cere...
CCJ30068  395 KVActfHSRVEECLDQSLNKMqlDYVDLYLMHWPvplnpkgndflfp-----kkpdgtldheegWDFIKTWGLFENLLST 469 Pneumocystis jirov...
POE49354  146 KLDntwHHRVEEGITSSLKSLdtDYVDLYLVHWPsstdpdd----------------lkkhlpdWDFIKTWQEMQKLPAS 209 Quercus suber
CCF54161   83 KVWctyHRQPEACLDESLEKLglDYVDLLLVHWPvplikrgdekip------lnedgsraidpeWTPEQTWELMEKLPAT 156 Ustilago hordei
EAA27685  104 KLDndwHKHVAEAIDTSLKNLdtPYVDLYLMHWPaslvkgn----------------tkevyndWDFVDTWREMQKLVDT 167 Neurospora crassa ...

Feature 1             ##                      #                         #######         #     
P14065    161 gKTKAVGVSNFSiNNLKDLLAsqgnKLTPAANQVEIHPLlpQDELINFCKSKGIVVEAYSPLGSTdapLLKEPVILEIAK 240 baker's yeast
Q12458    161 gKTKAVGVSNFSiNNIKELLEspnnKVVPATNQIEIHPLlpQDELIAFCKEKGIVVEAYSPFGSAnapLLKEQAIIDMAK 240 Saccharomyces cere...
CCJ30068  470 gKVKAIGVSNFStVNLEKLLKt--aKVIPAVNQCELHPYltQNKLVDFCNKKGIHLTAYSPLGSTnapLLKEPVIIKIAQ 547 Pneumocystis jirov...
POE49354  210 gRVKNIGVSNFAiKNLEKLLNdpstKIVPAVNQIELHPNnpSPKLVDYCKEKNIHATAYSCLGSTnspLVNDKTLAKIAE 289 Quercus suber
CCF54161  157 gKTKAIGVSNWSvPYLEKLLAn--aKIVPAANQVELHPFlpQHDLVKFCQSKGILMQAYSPLGSSggpVLQDELVQSIAK 234 Ustilago hordei
EAA27685  168 gKVKNIGVSNFGvKNLEKLLSaestKIVPAVNQIELHPGnpSPHLVEYLRSKGIHASAYSPLGSSdspLYKLNSLTKLAE 247 Neurospora crassa ...

Feature 1           #              ######  #  ##                        
P14065    241 KNNVqPGHVVISWHVQRGYVVLPKSVNPDRIKTNRKi--FTLSTEDFEAINNISKEKG 296 baker's yeast
Q12458    241 KHGVePAQLIISWSIQRGYVVLAKSVNPERIVSNFKi--FTLPEDDFKTISNLSKVHG 296 Saccharomyces cerevisiae S288C
CCJ30068  548 KNNKtPAQVIFSWCLHKNISVIPKSITPSRITSNLHv--FELSEEDFNEIDGLGKIYK 603 Pneumocystis jirovecii
POE49354  290 KHGKtTAQVLLVWGLQRGTSVIPKSVTASRIEKNFEldgFSLSDDELKELSSLPDRFK 347 Quercus suber
CCF54161  235 AHGAdPAQVVISWAAQRGVVALPKSVTASRIETNGKl--ITLSDDEMLKLNELHKQAG 290 Ustilago hordei
EAA27685  248 SKGKtVQQVLLRWGVQKGWSVLPKSVTEERIKANIDlegWSLTDEEIAQIDEVHKENS 305 Neurospora crassa OR74A

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap