4J2U


Conserved Protein Domain Family
ECH_2
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pfam16113: ECH_2 (this model, PSSM-Id:406503 is obsolete and has been replaced by 465024)
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Enoyl-CoA hydratase/isomerase
This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.
Links
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Statistics
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PSSM-Id: 406503
Aligned: 269 rows
Threshold Bit Score: 250.071
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4J2U_B         35 GRITLSRPAALNALTCAXVQEIDAALRGWIGDPEVELVVI-DAEGPRAFCAGGDIAELHGRGVAgDhafgqdFWRVEYRX 113  Rhodobacter s...
XP_004351918   54 LKIILNREKALNSLTLEMINHLLNLLKKYENDKRVTFVLV-VGAGDRAYCSGGDLLEFSSSVEM-Sh----rLSNTEYKL 127  Cavenderia fa...
Q55GN0         50 KRIILNRSEALNSLTMEMLKFLSEKLKEFNNDDNCKFVII-NSSTEKSFCSGGDIKEFSQLSRSsAgv--neFIRVEYAM 126  Dictyostelium...
EFC39337      937 RCLQINRPRESNRITSEVARDLLHQFKVMDTNPIINLITL-SGIGNGFLSAGYDFRELQNLMDKgDyetvysLVRDTHKL 1015 Naegleria gru...
EFA76756      193 ARAFLNNRKTLNAIDISTIDLLEEFVKDKIKDDTITSFSIhTSTPGVIHSAGTDFVTLFEKRNTeLpe---qYFRKLYKF 269  Heterostelium...
EGC32625      167 KRAMLNNREKLNVLDLSTLTSIEHFIKTQVANDIVGSYSIhTTTPGAIQSSGIDFVNLYESNQNrKyi--sdYFKKISKV 244  Dictyostelium...
EGG13538      179 SRALLNDRKTLNSLSDTTLRLIDEYLKEVIINERISCFSLhTSTPGLIQSAGTDFVAMFEKRNTeYpq---eYLKKLYKA 255  Cavenderia fa...
Q8I523        191 CEIILNRPEKLNAINKDMINALLNIIKSLDNDERCFMVII-RSTNSNCFSSGSDVKYVVENKEQgi-----qHLKQLYLY 264  Plasmodium fa...
CCB65997       28 QTFTLNRPSSLNALDNEMCRALLSAIPRVARNPDVYIVAL-VSSSPKAFCAGGDVVALSAAAKSdIata-ksYMRDEYSL 105  Hyphomicrobiu...
EFC47358       74 LCITLNRPKSFNALSLSMIRSLRRILEQALSDTKVHFVIL-QSASDKAFCAGGDIKDLRRGFEYaq-----qFFTEEFSL 147  Naegleria gru...

4J2U_B        114 NDRIAAFPK--PIVSLXQGFTXGGGVGLGCHARHRIVGETS-QISXPECAIGLVPDVGGTHLLARa--PG-RIGVWLGLT 187  Rhodobacter s...
XP_004351918  128 DYLIHTYSK--PYVSIVNGIVMGGGVGISIHGSHCIVTERA-LWAMPECFIGYFPDVGTNYQMSR---LG-AIGLYLDLT 200  Cavenderia fa...
Q55GN0        127 DHLIHTFNK--PILSFVNGIVMGGGVGLSIHSSHRIIGDNV-QWAMPENRIGYFPDVGTSYFLSR---LG-SIGLYLAMV 199  Dictyostelium...
EFC39337     1016 AYYAANCET--PTMSVINGLMLGPGTSLGTSANYVIATPGS-LFSAADSAYGYFPDCGVTMLLSRvnqKHeGLGTFLGLT 1092 Naegleria gru...
EFA76756      270 FYLLAASPK--PHVSILDGLAVGSGAAFTANSAVRVATENS-IFSVPDCAIGFFPDAGMARFLGKl--PG-SLGRYLAMT 343  Heterostelium...
EGC32625      245 FYLMSVAPK--PQLSIIDGLTVGAGLGFTANSGFRVGSENS-IVTISDCALGFFPNAGNVRLLNRl--PD-GIGLYLALT 318  Dictyostelium...
EGG13538      256 MYLLAITPK--PQINILDGLAVGSGAALTANSGIRVVTENA-VMSFPEAALGYFPDCGSMRLLARm--DG-FLGKYLALT 329  Cavenderia fa...
Q8I523        265 INYISQMKK--NLLCIWNGYVMGGGLGISIYSKYKVINKNA-IFAMPENKIGFFPDIGCCYFFRKy--FGrNIGLHLGLT 339  Plasmodium fa...
CCB65997      106 NWLLECFSK--PTVSFIDGLCMGSGAGLSAFNTHRIAGENF-KWAMPETKIGLFPDVGIARVLAKm--PW-PIGLYLGLT 179  Hyphomicrobiu...
EFC47358      148 NYYIHEFCKvkPIVSMLNGITMGGGVGISIYTNLRVANRKRfQFAMPEVFIGIYPDIGASFFLTRa-cSSiGIARYIGLT 226  Naegleria gru...

4J2U_B        188 GARXGPGDAIFAGFADRFVPEADW--PDLI----AALEGG---------DLALPDHA-------AP---E-GRL---Pvl 238  Rhodobacter s...
XP_004351918  201 GTRIKYRDLVGLGIASHHVPSDML--DRLV----RDLTENtvdt-trqlDFIINLYRkqv-gyrLHniePsTMVewlVqn 272  Cavenderia fa...
Q55GN0        200 GVKINSKDLINVKLATHYIPNELF--ERTL----EELCNDddiegyrqiEFILNKYRktl-ypdKE-----------Ssh 261  Dictyostelium...
EFC39337     1093 GAQVKSSDLVNCGIATSFGMESMS--QYIA----ERLLEVqtg---anqDDIHNCIVest-esdVPalsFaFEL---Y-- 1157 Naegleria gru...
EFA76756      344 GGRLRGSDIMESGIGNFYIRTNQI--QYIE----EWLGRVpin----rsDRLFANLDiht-enwDNkqsI-QKThyeQyk 411  Heterostelium...
EGC32625      319 GRRIRGTELHEAGITDFFVLTEDI--QGFD----RNLSHCfpk----nhNRLFESIVlst-tepRSylnG-KKThltThq 386  Dictyostelium...
EGG13538      330 GRRLRAGELIQTGVGNFYMRTAHI--PLIE----DSLCQLppn----rpDRMFLHLDths-dsfDDlv--sQPThytTyr 396  Cavenderia fa...
Q8I523        340 SLRLNEVDLINFNVCNNYIENVDTfmDNL-----NNIKATnqe----dfNKKLNNLLtnkyvskMSynkSnNPVltdEli 410  Plasmodium fa...
CCB65997      180 GRSIGRADAQWLRLVTHCISSSHF--EDIR----AKLada------qpvDPLLDDLNqpq---------epGDL---Qke 235  Hyphomicrobiu...
EFC47358      227 GAKLGATDSLFSKLVTNVIDNEEVf-YELRrdlfEKFIPTene---snlEKQLEKFIqiy-ekkGNtvlN-STLgqvd-- 298  Naegleria gru...

4J2U_B        239 ----qdEIDRLF-AG--T-LAEIPARLE-------------A--TDTP----LAAEAL-KALR-RSSPLALAATLEILQR 289  Rhodobacter s...
XP_004351918  273 -----qCLERCF-GNhiKsVQEVLDNLEne----------iKnnNGDEkvrkWAEQTL-TKIT-GSRPLSICACFKAFRD 334  Cavenderia fa...
Q55GN0        262 lvlyqsIINRCFnNKefKsVKEILNQLKveien----vdnkNnkDEIE----WASKTLsILLD-QLCPTSVCVSFEIIKR 332  Dictyostelium...
EFC39337     1158 ------KIKEHF-SNkkS-VEEIIQSLKntitdstktkperD----------WAANIL-ENMN-QLSPLSLKVTFRAIQE 1217 Naegleria gru...
EFA76756      412 -----eAIDRCF--SkaS-VEEIMDALRaet--------qhPa---------WAKRCL-DNMN-RMSPLSLKLTLVFMDY 464  Heterostelium...
EGC32625      387 -----dAIKRCF-DNktT-IEEVLQALEnet--------efAe---------WAERCI-RNIR-RSSPISIKLTMRLFNE 440  Dictyostelium...
EGG13538      397 -----eAIDRCF--SkdT-VEEIIEALHker--------qhSd---------WAKRCI-QNMN-KSSPLGLKLTNALYRH 449  Cavenderia fa...
Q8I523        411 -----nNINTYY-SSanT-LEDLITKLKk---------------DNND----FCKKLL-SDIY-SNCYFSCMFWFSYYLY 462  Plasmodium fa...
CCB65997      236 ----rgHINEHFsEP--T-LDGIFRSLe------------rAeaKGSE----WAQRTL-SGLR-KCSPISLAITLRHIQN 290  Hyphomicrobiu...
EFC47358      299 --rfrrVIDYCF-GEaqS-VKEIISNLKwyke-----hhpcRsqSDNE----FIDSIL-ELFSkRASPTSLVVTFEALER 364  Naegleria gru...

4J2U_B        290 LGPSAg-------IREALDLEYRFTYRAQG-QADFLEGIRAAIIDKDRSPrWRHGDPEAVRP-EEVASL 349  Rhodobacter sphaeroides ...
XP_004351918  335 SLNLS--------IDDVLKMDNRVGTHLTQiEEDGREGIKAALFDKTYKPqWIPPTIQQVDP-NIVDSL 394  Cavenderia fasciculata
Q55GN0        333 ALQMN--------IDQIFQMEVRVGTRLGN-RQDLTQGVFKTLIDKTHKPiYSPSSIYDINQ-SFIDSF 391  Dictyostelium discoideum...
EFC39337     1218 CDQGLg-------LDETYQRDYRIASRLIK-SKDFKQGVNSVLTGIE--PvWEFESVEKVPD-SVVDSL 1275 Naegleria gruberi
EFA76756      465 ALQPNplldqplsLKEHFEMEYRITSSLLEeGSDFWEGIRANLVYK-RAPqWKYKTLADVTD-EVIEHH 531  Heterostelium album PN500
EGC32625      441 TPTDGk-------GKDYYERDYNISMALTRdHSDLWEGIQSLLIQN-REPmWSYKRVEDVPD-SLIDEI 500  Dictyostelium purpureum
EGG13538      450 VAEAKet----isLRDLLSLEYKIANCLFEeGSDLWEGVRSNLVYG-RAPnYRYKTLSDVTD-SVIEDH 512  Cavenderia fasciculata
Q8I523        463 NYEKS--------LEEVLNNDFKITQYFLFhKNSFERGVTEVLVKKNKNFqWSKDEETNNADfEDIDDI 523  Plasmodium falciparum 3D7
CCB65997      291 ALRFd--------IRDTLIEDYRLAVRCLE-NHDFHEGVRALLRDKDGKPvWQPGRYEDVAA-DIVDGY 349  Hyphomicrobium sp. MC1
EFC47358      365 GRKASs-------LKQVLDLDKLLCTKLVG-QHDFVEGVRAVLVDKDQKPkFKPATLDELNVhQVIKEI 425  Naegleria gruberi
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