Conserved Protein Domain Family
OpcA
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TIGR00534: OpcA 
glucose-6-phosphate dehydrogenase assembly protein OpcA
The opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme, and Synechococcus sp. PCC 7942. In the latter, disruption of opcA was shown to block assembly of G6PDH into active oligomeric forms. [Protein fate, Protein folding and stabilization]
Links
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Statistics
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PSSM-Id: 213538
Aligned: 5 rows
Threshold Bit Score: 381.552
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P48971        22 SLQAPKDISLNEIDAELNQIWQSYGITGedgglpsATRATTFTLVVYePEETQYLLAALgfyngpidgilgpQMAAalre 101 Nostoc punctifo...
CAA19939       1 MRIDLTDTTASKINKALVQGRRAIGTPA-------VGMVLTLVIVTD-EENAYDATKAA-------------EEAS---- 55  Streptomyces co...
AAA98848       9 SLQKPTPIALAEIEESLSQLWANQQHSGag---alVSRAATFSIVVYePEEFQQILAALglyhghldglhgpMTAPrsp- 84  Synechococcus e...
WP_010907816   1 -----------------------------------MSRVLTLVITPYsKAMLKESIEAA-------------NGAS---- 28  Mycobacterium l...
WP_003911520   1 MIVDLPDTTTTAVNKKLDELREKIGAVA-------MGRVLTLIIAPDsEAMLEESIEAA-------------NDAS---- 56  Mycobacterium t...

P48971       102 vqkkHKLPetgtatQ-------ETLTILREEFAkgqrggtggehaiaglnsgspriadeiaL------------------ 156 Nostoc punctifo...
CAA19939      56 ----HEHP------S-------RTLVVIKRHPRn---------------------------L------------------ 73  Streptomyces co...
AAA98848      85 -kprHNSG------SstgrpdsATFKALRQAYQa---------------------------Lkhspsltnqdlrgavlsn 130 Synechococcus e...
WP_010907816  29 ----HKYP------N-------RIIIAMRVNS-----------------------------Y------------------ 44  Mycobacterium l...
WP_003911520  57 ----HEHP------S-------RIIVTMRGDP-----------------------------Y------------------ 72  Mycobacterium t...

P48971       157 ----RNPCRIialfpiTGEDEGVKAQVSAYCpiqkqssstlicceYITLSGTAAALERIGGMIPALLIGGLPKFLWWKAT 232 Nostoc punctifo...
CAA19939      74 ----RDRTRSh-----LDAEVRVGSEAGTGE--------------TVVLRTYGEVSEHADSVVLPLLLPDAPVVVWWPVE 130 Streptomyces co...
AAA98848     131 viatQNPCRIvslcptLEGDRPISAEVSAYCpitsakqaslicceRVTLRGSQAEMEAIGTFVSELLLPGLPRYVWWKAT 210 Synechococcus e...
WP_010907816  45 ----ANKAR-------LDAQLWVGADTGAG---------------VVVSRT---LAVYAHSVVISILLPDIPMVAWWPNI 95  Mycobacterium l...
WP_003911520  73 ----ADRPR-------LDAQLRVGADAGAGE--------------FVVLRLSGPLAGHADSVVIPFLLPDIPVVAWWPDI 127 Mycobacterium t...

P48971       233 PdPNNGLFKRLAAICNNVIVDSCNFNEPESDLLRLEELVEAGVplADLNWRRLASWQELTAEAYDSpkrraALREIDRVT 312 Nostoc punctifo...
CAA19939     131 A-PDNPAKDPLGALAQRRITDLYTVERPMEVLERRVRAYAPGD--TDLAWTRLTLWRSMLAAALDQ-----ARVPVTSAV 202 Streptomyces co...
AAA98848     211 PnPEQLLFQQLANSCNCMIFDSSYFSDPEAEFLRFQDLIDQETyiADLNWHRLAAWQELTAAAFDPperrdGLLEVDQLV 290 Synechococcus e...
WP_010907816  96 A-PTMSGQDSLGKLAIQRITNATNSIDPLATIKSRLSDYTADD--THLAWDLITYWRALLTSAVNLp----PHEPIDLAL 168 Mycobacterium l...
WP_003911520 128 A-PAVPAQDALGKLAIRRITDATNAIDPLSAIKSRLAGYGAGD--TDLAWSRITYWRALLTSAVDQp----RHEPIESAL 200 Mycobacterium t...

P48971       313 IDYEKGNPAQALLfLGWLASRLEWQpvsYQKESGD-YDITRIHFISQDqrqvEAELAGVPvadvgdiIGDLIALRLSSTn 391 Nostoc punctifo...
CAA19939     203 VEAEADNPAAELL-ARWMEARLGVR---VDRVVTDgPVVTAVRLGTAN----GEIVVDRP-------EGPLATMTLPGQ- 266 Streptomyces co...
AAA98848     291 IDYEKGNPAQALMyMGWIASRLGWQpvsYRCEGGE-YDLRQIEFRTEDdrmvKVELAGIPvgdpglvLGDLIALRLTSEn 369 Synechococcus e...
WP_010907816 169 VSGMKTEPALDVL-AGWLANRINRP---LRRAVAD----LKVELIRNS----ETIVLSRPq------TWVTSTLIRTVK- 229 Mycobacterium l...
WP_003911520 201 VSGLKTEPALDVL-AGWLASRIEGP---VRRAVGE----LKVELVRNS----ETIVLSRPq------EGITATLTRTGK- 261 Mycobacterium t...

P48971       392 PQAdCGTVICSETGGCMRMETHGGAQSAglFQQVTSLSEQKAEALLSQ 439 Nostoc punctiforme PCC 73102
CAA19939     267 PSR-SVALKVRPTSELIAEELRRLDADE--MYAVALRGKAGKETPVHV 311 Streptomyces coelicolor A3(2)
AAA98848     370 PDAdCCTILCSETTGCMRMEAGGGAQSCr-TEQVAPPSNETSESLLAM 416 Synechococcus elongatus PCC 7942
WP_010907816 230 PDA-LVPWGAQGS---RGVPSRKSATTG--SRQVLLQCLRRH------ 265 Mycobacterium leprae
WP_003911520 262 PDA-LVPLARRVTGECLAEDLRRLDPDE--IYCAALEGIKKVQYR--- 303 Mycobacterium tuberculosis complex
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