Conserved Protein Domain Family
deoxycytidylate_deaminase
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cd01286: deoxycytidylate_deaminase 
Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the enzyme is allosterically regulated by the ratio of dCTP to dTTP not only in eukaryotic cells but also in T-even phage-infected Escherichia coli, with dCTP acting as an activator and dTTP as an inhibitor.
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Statistics
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PSSM-Id: 238613
Aligned: 37 rows
Threshold Bit Score: 126.62
Created: 3-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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catalytic motifZn binding site
Feature 1:catalytic motif [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     #                                 
P32321       16 PEYFMAvaflsa-qrskdpNSQVGACIVnsenki------vgigynGMPNGCSDDvlpwrrtae---------------- 72  human
NP_229832   267 DEIGMHaaysaa-lrsaclSRQVGAAILdnqgniistgcndvpsfgGGLYNSNSLadfrcvhtgrcsndkhkdilkeeit 345 Vibrio cholerae
NP_762166   345 DERCMQiaynak-lnsgclSRQVGAVVTdsdksikav-gwnnvaqgQTPCNLRRAedlltnedesafslferentkfrts 422 Vibrio vulnificu...
NP_296350     7 DDLGLAtarlwa-trsadpKVQVGACILdrhhrv------vgvgynGRAAGEPNEresla-------------------- 59  Deinococcus radi...
NP_112173   319 ARHCMVqarlla-yrtedhKTGVGAVIWaegksrs----cdgtgamYFVGCGYNAfpvgseyadfphmd----------- 382 human
ZP_00116922   8 DDIYMElavnla-krshciKRHVGAVLTkdtrii-------sigynGPPEKTHNCdeewpeegcp--------------- 64  Cytophaga hutchi...
CAA17893    201 DSYFMEmaslaa-krsncmKRRVGCVLVrgnrvi-------atgynGTPRGATNCneggcprcnsa-------------- 258 fission yeast
P06773      164 DSYFMKlatlaa-srsncmKRRVGCVIVrecrvi-------atgynGTPRHLTNCfnggcprcnd--------------- 220 baker's yeast
XP_326959   239 DSYFMAlaslaa-qrsncmKRRVGCVVVrdkrvi-------stgynGTPRGLINCgeggcgrcneg-------------- 296 Neurospora crassa
ZP_00043728   7 DIHWMRvaklaaemstcasGRRVGAVFVrdkrll-------atgfnGVPSGYPHPtscarreagv--------------- 64  Magnetococcus sp...

Feature 1                                                  # #                         ##  #    
P32321       73 --------------------------------nkldtkypyVCHAELNAIMNKns---tdVKGCSMYVALFPCNeCAKLI 117 human
NP_229832   346 dilkk-------sitntlelkeivnqitsetkiktlieysrAVHAEMDSLIALarnnketSVDKTLYVTTYPCHnCARHI 418 Vibrio cholerae
NP_762166   423 lgniysftesinksfrgkpvsycfkdiknsidgeknqvhtrALHAEENAFLQVskyggmpVKHGYLYTTASPCElCAKKA 502 Vibrio vulnificu...
NP_296350    60 ------------------------------------qgasgYIHAEVNALLAAnw----nGEGHTLYVTHEPCSvCARLI 99  Deinococcus radi...
NP_112173   383 ----------------------------dkqkdreirkfryIIHAEQNALTFRcqe-ikpEERSMIFVTKCPCDeCVPLI 433 human
ZP_00116922  65 --------------------------------rdskgscslALHAEENAILFAvkn-gteVKGATIYVTLSPCIsCARLL 111 Cytophaga hutchi...
CAA17893    259 ------------------------------sscgkeldtclCLHAEENALLEAgre--rvGNNAILYCDTCPCLtCSVKI 306 fission yeast
P06773      221 -------------------------------gdsrnlhtclCLHAEENALLEAgrd--rvGQNATLYCDTCPCLtCSVKI 267 baker's yeast
XP_326959   297 ------------------------------qgsgqglstclCMHAEENALLEAgre--rvREGAVLYCDTCPCLtCSIKI 344 Neurospora crassa
ZP_00043728  65 -------------------------------psgqglglcvCAHAEANGIANAgrh-gikLEGCRVYVTTHPCGaCMGAL 112 Magnetococcus sp...

Feature 1                                        
P32321      118 IQAGi-kEVIFMSDkyhd-------sdeATAAR 142 human
NP_229832   419 VAAGi-kKVVYVEPyeksl----amklhDDSIS 446 Vibrio cholerae
NP_762166   503 YQLKi-dSVIFIDPypgva----ndhiiNCGVD 530 Vibrio vulnificus CMCP6
NP_296350   100 VNSRrvgRVVFATPyretarveaglpsgAEILR 132 Deinococcus radiodurans
NP_112173   434 KGAGi--KQIYAGDvdvgkk--kadisyMRFGE 462 human
ZP_00116922 112 FASGv-kKVIYLHSyaeykg--ldvdegNAFLS 141 Cytophaga hutchinsonii
CAA17893    307 TQLGi-kEVVYHTSynmd-------shtASLLQ 331 fission yeast
P06773      268 VQTGi-sEVVYSQSyrmd-------eesFKVLK 292 baker's yeast
XP_326959   345 AQVGi-sEVVYSQGysmd-------getAAVFR 369 Neurospora crassa
ZP_00043728 113 ANIGv-kEVFYAEAydd--------praKDIAD 136 Magnetococcus sp. MC-1

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