Conserved Protein Domain Family
bHLHzip_USF3
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cd18910: bHLHzip_USF3 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix domain-containing protein USF3 and similar proteins
USF3, also termed upstream transcription factor 3, is a bHLHzip protein that is involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties.
Links
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Statistics
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PSSM-Id: 381480
Aligned: 16 rows
Threshold Bit Score: 85.8145
Created: 26-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences.
  • Comment:Based on the structure evidence that Mus musculus Mitf (4ATI) binds DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 ## ##  ##   #                    ##                        
Q68DE3         15 HRKKNRETHNAVERHRKKKINAGINRIGELIPcsp--alKQSKNMILDQAFKYITELKRQNDELLLN 79   human
CBN81963        7 RKKKNKESHNAVERHRKEKINAGINRIGNLLPcsq--alKQSKNMILEQAFRYITELKKQNDTMLLE 71   European seabass
XP_019642438  124 RRYRKRAVHNEVERRRKDKINAGILRIGELLPctqqekqVVSKRGILDKAYDYIVKLSKEHEHMLMN 190  Belcher's lancelet
XP_001199252   43 EKAKRKSHHAEIEKRRKSKLNEGINKLIDILPdr---daKRSKVQILEDTYQLVVELKKKCNQLMIQ 106  purple sea urchin
OQR73953       21 GKEYRKWQHNEHERRRKDKISAGILRLGELLPdrd--prRMAKVDILSRACEYITYLRDLNEKIVAN 85   Tropilaelaps mercedesae
XP_022109533   73 QERKKRDSHNEIERRRKCKINIGIIKLGDIIPicq--ttKMSKNQILEQACLYIDELREKSEKLLLA 137  crown-of-thorns starfish
XP_013391981   30 SKGRNREAHRGNEKKRKEKTRTLIAQIADMLPgya-svkNKSMNMTLERAVMYMIELKEKNDQMLLN 95   Lingula anatina
KPM07539       11 KEDFKKLIHNVIERKRKHRIFELIDEIIELLPfkn-eykNKSKRKKLERIHSYIIDLKNKNDALMFA 76   Sarcoptes scabiei
XP_023213903   33 GQDRRRRVHNEVERRRKDKINSWILRIGELLPdkn--rkKQCINEILEQAVVYISYLKDSNDKLLQE 97   bark scorpion
XP_022256813   22 RRLHKRRMHNEVERRCKDKINSWILKIGELLPdrd--skRQSKNGILEKAVEYIDYLQKANEKLLMD 86   Atlantic horseshoe crab

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