Conserved Protein Domain Family
ApoO
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pfam09769: ApoO (this model, PSSM-Id:401644 is obsolete and has been replaced by 462891)
Apolipoprotein O
Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
Links
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Statistics
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PSSM-Id: 401644
Aligned: 112 rows
Threshold Bit Score: 96.8301
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007289198  75 PTPTDRLAVQIRKTRLFLYSHVLAAETKV-----------NQLMDSALDLEDSFTSTVASLAPTPqsgEKLMPGTLYVLV 143 Marssonina brun...
Q7T173        58 EPDVGPVEQGVASLRKTVEPYCSWCQERTqfavdkiqsyyKTVEPGVDTTQNIVQDIFTFLKDPP---SEFYPSVGVIGF 134 zebrafish
3_pfamImport  14 EPEAGSLEQSVTSLRKWAEPYTNQCQQTCqmvmekveevyRSVEPAVATSVSTVSEAYQFLSDPP---PNLYPSVAAVGF 90 
XP_007670434  53 ENRQSPLEEYVSHVRHSAEPYTSWCQDVY-----------CKTKPKVDIAVQQGKDGYEFLCNAP---PGFYPRLGVIGF 118 platypus
XP_007493475  54 EEPRSPLEEGISQLRKYAGPYTYWFQDAY-----------NKTKPTVDAAIQQGIASCEILQNPP---PGFLPRLGVIGF 119 gray short-tail...
XP_006085688  54 EEPRTQLEESISHLRQYCKPYTSWCQEMY-----------SQTEPKMQSLVQWGLDSYEFLQNAP---PGFFPRLGVIGF 119 little brown bat
XP_005334861  54 EEPRTQLEESISQLRHHFEPYTSWCQETY-----------SKTKPKMQSLVQWGLDSYEYLQNAP---PGFFPRLGVIGF 119 thirteen-lined ...
XP_023410919  65 EEPRTQLEENISQLRHYCEPYTSWCQEKY-----------FYTKPKVQSIVQWGIDNYEYLQNAP---PGFFPRLGVIGF 130 African savanna...
AAI55971      54 EDKQTQLEEGVSWVRQAVAPYTSWCQDAY-----------IKAKPKFETAVEHSKGTYEFLKDAP---PGFYPRLGLIGF 119 tropical clawed...
XP_006011766  51 EEEPSKLEENISWFRQSAEPYTAKCQEVY-----------TKAKPKLQNVAELGKESYEFLNSPP---QGFYPRLGVIGF 116 coelacanth

XP_007289198 144 AAMTGSIVSRnRNILLRATVPLAVGIGAGWVVLPVT----MRNVSDLLWKYEQ-RFPAV 197 Marssonina brunnea f. sp. 'multigerm...
Q7T173       135 SGILGLFFAK-GSTVKRLIFPTGLMALCASVFYPQHaasaARTTKDYMYSWGSeGRAVL 192 zebrafish
3_pfamImport  91 SGLLGLYLAK-GSRVKRVVFPAGLMALSASVFYPQLtaslLKASRDRALTWAQqGRG-- 146
XP_007670434 119 AGVVGLFLAR-GSRIKKLIYPLGFMGLGTSLYYPQQaitfAQISGEKLYDWGLrGYVTL 176 platypus
XP_007493475 120 SGILGYFFAR-GSKLKKLVYPIGFMSITASVYYPQEafefAQVNGEKLYDWGLrVFIil 177 gray short-tailed opossum
XP_006085688 120 AGIIGLLLAR-GSKIKKLVYPPSFMGLAASLYYPQQaivfFQVSGEKLYDWSLrGYIVV 177 little brown bat
XP_005334861 120 AGLVGLLFTR-GSKIKKLVYPPAFMGLAASIYYPQQaiafAQVTGEKLYDWGLrGYIVI 177 thirteen-lined ground squirrel
XP_023410919 131 AGLVGLLFAR-GSKIKKLIYPPGFMGFAASVYYPQQaisfAQVSGELLYDWGLrGYIVI 188 African savanna elephant
AAI55971     120 AGIVGLFLAR-GSRVKKVIYPLGFMGLGASLYYPQQavtiAKDTSAVMYDWGLqGVVTL 177 tropical clawed frog
XP_006011766 117 AGIAGLFFAR-GSRIKKVVYPLGLMAFGASLYYPQQaaafAKGTGSAVYDWSLqAYVAV 174 coelacanth
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