1VGT,1VPA,1VGZ,1W55,2XWN


Conserved Protein Domain Family
ispD

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TIGR00453: ispD 
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2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Members of this protein family are 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, the IspD protein of the deoxyxylulose pathway of IPP biosynthesis. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 213532
Aligned: 25 rows
Threshold Bit Score: 228.711
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1VGT_A  11 CAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQi----tVVDGGDE 86  Escherichia coli
Q8R7S6   4 SAVIVAAGRSTRMNKSLNKVYLSIAGKPVLYYSIKAFDEIEWIKEIIVVTSPEETEYCQENVLEKFYwnkpfkIVKGGEE 83  Caldanaerobacter subt...
Q06755   4 DVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHRQCDKIILVINEQEREHFQQ-LLSDYPfqtsieLVAGGDE 82  Bacillus subtilis sub...
O67343   3 TAIILAAGRGSRIGFR--KQFATLCGKPLFMHSLEKVLD--IFEEVILVLP-ED--FLDK-----VKvhpkvkKVAGGPE 70  Aquifex aeolicus VF5
Q9PJT1   6 SLVLLGGGRGERFNSPQPKQYTPLCGEPLILHALHSYQSLPFIQEIVVVCEEHYQELFSPYSv---------kFASPGAL 76  Chlamydia muridarum s...
Q9Z7X5   5 SLILLSGGQGTRFGSKIPKQYLPLNGTPLVLHSLKILSSLPQIAEVIVVCDPSYQETFQEYPv---------sFAIPGER 75  Chlamydia pneumoniae
Q9X1B3   3 VAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRVFHEKvl----gIVEGGDT 78  Thermotoga maritima MSB8
Q9ZM19  40 SVVLLAAGESKRFSRAIKKQWLRSHHTPLWLSVYESFKEALDFKEVILVVSELDYVYIQRHYPKi-------kLVKGGAS 112 Helicobacter pylori J99
Q9PM68   5 SLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNIT--YMKKFTKNy-------eFIEGGDT 75  Campylobacter jejuni ...
1VPA_A  15 VAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRVFHEKVl----gIVEGGDT 90  Thermotoga maritima
1VGT_A  87 RADSVLAGLKAA-G-DAQWVLVHDAARPCLHQDDLARLLALSETsRT-GGILAAPVRDTMKRAEpGKNAIAHTVDRNGLW 163 Escherichia coli
Q8R7S6  84 RQYSVYNGISVVd-kDCEIVAIHDGARPLVTKEIIMEAIKAAYL-YK-AAAVGVPVKDTIKVAD-EDNFILDTPDRRYLW 159 Caldanaerobacter subt...
Q06755  83 RQHSVYKGLKAVk--QEKIVLVHDGARPFIKHEQIDELIAEAEQ-TG-AAILAVPVKDTIKRV--QDLQVSETIERSSLW 156 Bacillus subtilis sub...
O67343  71 RQDSVFNALLQA---TGDIVVIHDSARPLATKKMFLEVAQLGDY-HG--KVVASPARDTLKEV--VEGKVIKTLNRSLIW 142 Aquifex aeolicus VF5
Q9PJT1  77 RQDSVFSGLQQV---SLPWVCVHDGVRPFVYANEVSEVCSAALK-TG-AAALATSATYTIKSR-----TPVRTLDRDAVA 146 Chlamydia muridarum s...
Q9Z7X5  76 RQDSVFSGLQQV---SYPWVIIHDGARPFIYPDEIHDLLETAEK-IG-ATALASPIPYTIKQR-----NPVRTLDRDNLA 145 Chlamydia pneumoniae
Q9X1B3  79 RSQSVRSALEFLeKfSPSYVLVHDSARPFLRKKHVSEVLRRARE-TG-AATLALKNSDALVRV---ENDRIEYIPRKGVY 153 Thermotoga maritima MSB8
Q9ZM19 113 RQESVRNALKVI---DSTYTITSDVARGLANMEALKSLFLTLQQtSHyCIAPYLPCYDTAI-------YYNEALDREAIK 182 Helicobacter pylori J99
Q9PM68  76 RAESLKKALELI---DSEFVMVSDVARVLVSKNLFDRLIENLDKaD--CITPALKVADTTL-------FDNEALQREKIK 143 Campylobacter jejuni ...
1VPA_A  91 RSQSVRSALEFLeKfSPSYVLVHDSARPFLRKKHVSEVLRRARE-TG-AATLALKNSDALVRVE---NDRIEYIPRKGVY 165 Thermotoga maritima
1VGT_A 164 HALTPQFFPRELLHDCLTRALNEGATITDEASALEYC-GFHPQLVEGRADNIKVTRPEDLALAEFYL 229 Escherichia coli
Q8R7S6 160 AIQTPQVFEKELIVKAHRKALEEGFLGTDDSVLVERM-GFKVKLVEGDYKNIKITTPEDLVVAELFL 225 Caldanaerobacter subterraneus subs...
Q06755 157 AVQTPQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMeGGSVRVVEGSYTNIKLTTPDDLTSAEAIM 223 Bacillus subtilis subsp. subtilis ...
O67343 143 HAQTPQAFRRDILLECHMRAKAEGFVGTDDASLLERY-GYSVGVVEGSYWNVKITYPEDLEMVKKIM 208 Aquifex aeolicus VF5
Q9PJT1 147 VIHTPQCINTEILKEGLLLANMMDFTLSDDSEAAELL-GIEPTLVFSNRVQMKITYPEDLLFAEALL 212 Chlamydia muridarum str. Nigg
Q9Z7X5 146 IIHTPQCIKTEILREGLALAKEKQLTLVDDIEAAEII-GKPSQLVFNKHPQIKISYPEDLTIAQALL 211 Chlamydia pneumoniae
Q9X1B3 154 RILTPQAFSYEILKKAHE----NGGEWADDTEPVQKL-GVKIALVEGDPLCFKVTFKEDLELARIIA 215 Thermotoga maritima MSB8
Q9ZM19 183 LIQTPQLSHTKTLQSALN----QG-GFKDESSAILQAfPNSVSYIEGSKDLHKLTTSGDLKFFTPFF 244 Helicobacter pylori J99
Q9PM68 144 LIQTPQISKTKLLKKALD----QNLEFTDDSTAIAAM-GGKIWFVEGEENARKLTFKEDLKKLDLPT 205 Campylobacter jejuni subsp. jejuni...
1VPA_A 166 RILTPQAFSYEILKKAH----ENGGEWADDTEPVQKL-GVKIALVEGDPLCFKVTFKEDLELARIIA 227 Thermotoga maritima
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