2PPQ,1ZYL


Conserved Protein Domain Family
APH
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pfam01636: APH (this model, PSSM-Id:396281 is obsolete and has been replaced by 426359)
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Phosphotransferase enzyme family
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.
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Statistics
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PSSM-Id: 396281
Aligned: 143 rows
Threshold Bit Score: 52.1243
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2PPQ_A  26 SYKGIAEG-VENSNFLLHTTK-DPLILTLYEKRv-EKNDLPFFLGLXQHLAAKGLscplPLPR-KDge--lLGELSGRPA 99  Agrobacterium fabrum ...
Q8EJX4  45 TGLLALNS-YENRVYQFRSDEgQRYVVKFYRPDrwSDAQIQEEHDFALALAEQEIp--mAVPTaVQgh--tLHHFQGFRF 119 Shewanella oneidensis
Q7N9F6  32 GLTELNS--YENRVYQFTDEDrKRYVVKFYRPLrwNQQQIQEEHDFALALQQADLp--vAAPLvFNkq--tLLTFKDFFF 105 Photorhabdus laumondi...
1ZYL_A  30 GLTPLNS--YENRVYQFQDEDrRRFVVKFYRPErwTADQILEEHQFALQLVNDEVp--vAAPVaFNgq--tLLNHQGFYF 103 Escherichia coli
Q8ZKU8  30 gLTPLNS--YENRVYQFQDEDrRRFVVKFYRPErwSVDQIREEHQFALELVKDEV----PVAApLAfngqtLLAHQGYHY 103 Salmonella enterica s...
Q9KVV4  42 GFLPLNS--YENRVYQFTDEErRRFVVKFYRPQrwTDEQIQEEHDFALELEQEEIpi-vP-PLrLNga--tLHHYQGYRF 115 Vibrio cholerae
Q87KC4  42 GFLPLNS--YENRVYQFTDEErRRYVVKFYRPErwSNEQIQEEHDFTLELIDSEIpvapPVr--INgn--tLHHYQGYGF 115 Vibrio parahaemolyticus
Q88QX5  36 DARVLALNsYENRVYQVGIEDaQPLIAKFYRPGrwSDAAILEEHAFTAELADCEVp--vVAPMqHDdr--tLFEHKGFRF 111 Pseudomonas putida KT...
Q9I632  25 DARVLALNsYENRVYQVGIEDgEPLIAKFYRPDrwSDAAIREEHAFSAELAECEVp--vVAPLsRDge--sLFAFSGFRF 100 Pseudomonas aeruginosa
Q7NZB5  31 SLLALNS--YENRVYQVGLDDaAPLVAKFYRPArwSDAAILEEHAFSLQLAEREIpa-vP-PLaFGgr--tLHGHGGFRF 104 Chromobacterium viola...

2PPQ_A 100 ALISFleGXWLRKpea-------khcREVGKALAAXHLA-------SEGFEIKRp------NALS------VDGWKVLWD 153 Agrobacterium fabrum ...
Q8EJX4 120 ALFPSigGRAFEVdnl-------eqlEFVGRFIGRMHQYg-----aQSVFQAREp------LNPQilgdepLAWLKQSEL 181 Shewanella oneidensis
Q7N9F6 106 AVFPSigGRQYESdnl-------fqlEDVGRLLGRIHQI-------GRRQKFTSr------PTIG------LNEYLHQPR 159 Photorhabdus laumondi...
1ZYL_A 104 AVFPSvgGRQFEAdnidqmeavgrylGRMHQTGRK--QLf-----iHRPTIGLNe------YLIE------PRKLFEDA- 163 Escherichia coli
Q8ZKU8 104 AIFPSvgGRQFEAdni-------dqmEAVGRYLGRLHQTg-----rKRPFTFRPdig--laEYLF------EPRQVFED- 162 Salmonella enterica s...
Q9KVV4 116 ALFTSmgGRQYEVdne-------ehlEWVGRFLGRIHKVg-----aSKPFLHRP--------TLS------LDEYLHQPR 169 Vibrio cholerae
Q87KC4 116 ALFESvgGRQFEVdnl-------eqlEGVGRFLGRIHKV-------GSRQAFQHrptiglqEYLY------QPREILQN- 174 Vibrio parahaemolyticus
Q88QX5 112 TLFPRrgGHAPEpgnl-------dqlYRLGQLLGRLHAVg-----aSKPFKHREa------LAVDnfghasLNTLLEGNF 173 Pseudomonas putida KT...
Q9I632 101 ALFPRrgGRAPEpgnl-------dqlYRLGQLLGRLHAVg-----aTRPFEHREa------LAVDnfghasLATLLEGNF 162 Pseudomonas aeruginosa
Q7NZB5 105 ALFERrgGRVPELdrd-------etlQWVGRFLGRIHALgrtegyrHRPTLDMQs------FGRE------PVDFVLGG- 164 Chromobacterium viola...

2PPQ_A 154 KsEERADEVEKgl-----reEIRP------EIDYLAAHWPKDLPAGVIHADLFQDNVFFLg--DELsgLIDFYFACNDLL 220 Agrobacterium fabrum ...
Q8EJX4 182 VpTSLRVAFFTvv------eQVLA------KVNTLWAQQR--FKPIRLHGDLHPGNILWTpdgPG---FVDLDDARMGPA 244 Shewanella oneidensis
Q7N9F6 160 Q-YLAACELVPagqkrqflaVLDD------LINAVASNWRDDWQILRLHGDCHPGNILWRd--EAW--FVDLDDARNGPA 228 Photorhabdus laumondi...
1ZYL_A 164 --TLIPSGLKAaf------lKATDe-----LIAAVTAHWREDFTVLRLHGDCHAGNILWRd--GPM--FVDLDDARNGPA 226 Escherichia coli
Q8ZKU8 163 A-ALIPSGQKAaf------lKATDt-----LLSAVTECWRTDFATLRLHGDCHAGNILWRd--GPL--FVDLDDARNGPA 226 Salmonella enterica s...
Q9KVV4 170 HtLEYSHCIPAh-------lQRVFfhdldiLIAEIKQHWVPTQPQIRLHGDCHPGNILWRd--GPM--FVDLDDARNGPA 238 Vibrio cholerae
Q87KC4 175 --ANMIPMHLEnsf----fnDLDM------LIKAIENHWQGSFATIRLHGDCHPGNILWRd--GPM--FVDLDDSRNGPA 238 Vibrio parahaemolyticus
Q88QX5 174 VpHELLPAFESva------rDLLKr-----VEDIYARTPH---QLIRLHGDLHPGNLMHRd-eVYH--VVDLDDCRMGPA 236 Pseudomonas putida KT...
Q9I632 163 IpRSLLPAYESva------rDLLKr------LDALFAEVP--YQPIRLHGDCHPGNLLCRd-dVYH--MVDLDDCRMGPA 225 Pseudomonas aeruginosa
Q7NZB5 165 --GWLPPELEAvyrg--vaeQALQg-----VARCFERAGP--VAQLRLHGDCHVGNLLWTdagPH---FVDFDDSRMGPA 230 Chromobacterium viola...

2PPQ_A 221 AYDVSICLNAWCfEKDGAYNVTKGKALl----EGYQSVRPL 257 Agrobacterium fabrum str. C58
Q8EJX4 245 IQDLWMML-TGDrAQQQLQLEVLLEAYeefceFDTRQLALI 284 Shewanella oneidensis
Q7N9F6 229 IQDLWMLL-HGSrQEQLLQLDTLLEAYsefadFDPKELSLI 268 Photorhabdus laumondii subsp. laumondii
1ZYL_A 227 VQDLWMLL-NGDkAEQRMQLETIIEAYeefseFDTAEIGLI 266 Escherichia coli
Q8ZKU8 227 IQDLWMLL-NGDkAEQRMQLETIIEAYeevseFDTaeigli 266 Salmonella enterica subsp. enterica serovar Typhimurium str....
Q9KVV4 239 IQDLWMLL-HGDrQDKLIQLDIVLEGYqefcdFNPQQLKLI 278 Vibrio cholerae
Q87KC4 239 VQDLWMLLNGERqDKLMQLDIILEAYQef-cdFNAAELKLI 278 Vibrio parahaemolyticus
Q88QX5 237 VQDLWMMLAGNReERLGQLAELIDGYNef-hdFDPRELALI 276 Pseudomonas putida KT2440
Q9I632 226 LQDLWMML-AGErHERLAQIAELVDGYnefhdFDPRQLPLL 265 Pseudomonas aeruginosa
Q7NZB5 231 VQDLWMLL-SGErAEQSRQLGEVLAGYedfceFDLRELNLL 270 Chromobacterium violaceum
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