Conserved Protein Domain Family
caca

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TIGR00845: caca 
sodium/calcium exchanger 1
The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Statistics
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PSSM-Id: 273296
Aligned: 8 rows
Threshold Bit Score: 1365.63
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q01728     1 MLRLSLPPNVSMGFRLVTLVALLFTHVDHITA--DTEAETGGNETTECTGSYY--------------------------- 51   Norway rat
P32418     4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIA--ETEMEGEGNETGECTGSYY--------------------------- 54   human
AAA97928   1 MPRFSLSPPFSMGFHLLAIVALFFFRVDHVSA--ETEMEGEGNETGECTGSYY--------------------------- 51   rabbit
P70549     1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAgdLRDVPSAGQNNESCSGSSD--------------------------- 53   Norway rat
P48768     1 -----MAPLALVGVALLLGAPHCLGEATPTPSlpPPPANDSDASPGGCQGSYR--------------------------- 48   Norway rat
AAB52920   1 -----MNP-FKISFSWGVPLFLLGLFFDFAHA------SE-DSNDTCTTEAET--------------------------- 40   Doryteuthis opales...
AAB50166   4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83   fruit fly
B89047       --------------------------------------------------------------------------------      Caenorhabditis ele...
Q01728    52 ----------------CKKGVILPIWEPQ-DPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKK 114  Norway rat
P32418    55 ----------------CKKGVILPIWEPQ-DPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKK 117  human
AAA97928  52 ----------------CKKGVILPIWEPQ-DPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKK 114  rabbit
P70549    54 ----------------CKEGVILPIWYPE-NPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKK 116  Norway rat
P48768    49 ----------------CQPGVLLPVWEPD-DPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITK 111  Norway rat
AAB52920  41 ----------------CRNGLIVPRWNPVgNLSVGDKLARATVYFVLMFYLFLGVSIIADRFMAAIEVITSKEKDVVVKK 104  Doryteuthis opales...
AAB50166  84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163  fruit fly
B89047     1 --------------------------------------------------MFLGISIVADRFMSSIEVITSMERTIVVKR 30   Caenorhabditis ele...
Q01728   115 PNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRK 194  Norway rat
P32418   118 PNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRK 197  human
AAA97928 115 PNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRK 194  rabbit
P70549   117 PNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRK 196  Norway rat
P48768   112 ANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRK 191  Norway rat
AAB52920 105 PDGTTTVVNVRIWNETVSNLTLMALGSSAPEILLSVIEVVGQKFEAGQLGPSTIVGSAAFNLFIITAICVTVIPNGEVRT 184  Doryteuthis opales...
AAB50166 164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243  fruit fly
B89047    31 PGLDPMAVQVRIWNDTVSNLTLMALGSSAPEILLSIIEVIARGFEAGDLGPNTIVGSAAFNLFMIIAICVVVIPKGEIRR 110  Caenorhabditis ele...
Q01728   195 IKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIE 274  Norway rat
P32418   198 IKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIE 277  human
AAA97928 195 IKHLRVFFVTAAWSIFAYTWLYIILSVISPGIVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIE 274  rabbit
P70549   197 IKHLRVFFVTAAWSVFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKRYRTDKHRGIIIE 276  Norway rat
P48768   192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIG 271  Norway rat
AAB52920 185 IKHLGVFFITATWSVFAYLWLYFILAVSSYGVVDVWEGLLTFMFFPATVVTAYIADRRLLN-KYLSKKYRASKQKGVIVQ 263  Doryteuthis opales...
AAB50166 244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVN-KRGTVVA 322  fruit fly
B89047   111 QKHLDVFCVTATWSVFAYVWLYLILAFFSPGEIEIWEGALTFIFFPLTVFTAYMADIKLIQNKFLPHRYRRG-SHGQMIA 189  Caenorhabditis ele...
Q01728   275 HEGDRPASKTEIEMDGKVVNSHVDNFLDGALV--LEVDERDqddeEARREMARILKELKQKHPDKEIEQLIELANYQVLS 352  Norway rat
P32418   278 HEGDRPSSKTEIEMDGKVVNSHVENFLDGALV--LEVDERDqddeEARREMARILKELKQKHPDKEIEQLIELANYQVLS 355  human
AAA97928 275 HEGDRPSSKTEIEMDGKVVNSHVDNFLDGALV--LDVDERDqddeEARREMARILKELKQKHPEKEIEQLIELANYQVLS 352  rabbit
P70549   277 TEGEHPKG---IEMDGKMMNSH---FLDGNLIp-LEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALS 345  Norway rat
P48768   272 AEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELD----ASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALL 344  Norway rat
AAB52920 264 CEGQDAEAGEGKSEDGALKEGG-----DD--V---EVREFEq----HRKEYIEILREMRKKNPTLDMKTLEDMAESEAVN 329  Doryteuthis opales...
AAB50166 323 GEHDQVEMDAEKGPKQPMVTSARGN----------DAEAFD----EARREYITLLTELRQKYPDADLEQLEMMAQEQVLA 388  fruit fly
B89047   190 TEAEEMKM-----LENGTQGDP-------------ALKAFE----EHRQEFIELMREIRKQNPHITPTELQKQAEYEMIS 247  Caenorhabditis ele...
Q01728   353 QQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSM--HEVNMDVVENDPVSKVFFEQGTYQCLENCGTVALTIIRRG 430  Norway rat
P32418   356 QQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSM--HEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRG 433  human
AAA97928 353 QQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSM--HEVNTEMAENDPVSKIFFEQGTYQCLENCGTVALTIIRRG 430  rabbit
P70549   346 HQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKTASM--SEVHTDEPE-DFASKVFFDPCSYQCLENCGAVLLTVVRKG 422  Norway rat
P48768   345 HQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG----ANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQG 420  Norway rat
AAB52920 330 RGPKSRAFYRIQATRKLTGSGNIIKKAKAQAGVAQP------IVIDQKPEDEITRVSFDPGHYTVMENVGTFYGTVTREG 403  Doryteuthis opales...
AAB50166 389 RSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG 468  fruit fly
B89047   248 RGPKSRAFYRVQATRRLIGGGDIVKKRIDKEHNKALDA--LVQAQEKQSRDNTCKIFLDPAHYTVLESVGSFDVVVGRDG 325  Caenorhabditis ele...
Q01728   431 GDLTNTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSsevSEDGILDSN 510  Norway rat
P32418   434 GDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSseaSEDGILEAN 513  human
AAA97928 431 GDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSsetSEDGILEAN 510  rabbit
P70549   423 GDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRVEeeqLEEGMTPAI 502  Norway rat
P48768   421 GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVG---DAQGMFEPD 497  Norway rat
AAB52920 404 GDLTKTLYVDYKTEDGTANAGSDYVYAEGTLVFYPMETHKQFPISIIDDDIFEEDEHFYIRLSNLRVG---DSNGLFESG 480  Doryteuthis opales...
AAB50166 469 -DISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEG------------ 535  fruit fly
B89047   326 GPDGLTVMVDYFTEDGSANAGSDYIPVKGTLTFYPEDKHQKVTIEVVDDDVFEEDEHFYLRLCNLRVR---TKDGIIIDP 402  Caenorhabditis ele...
Q01728   511 HVSA---IACLGSPNTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFED 587  Norway rat
P32418   514 HVST---LACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFED 590  human
AAA97928 511 HIST---LACLGSPCTATVTIFDDDHAGIFTFEESVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFED 587  rabbit
P70549   503 LNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFED 582  Norway rat
P48768   498 GGGRp--KGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYED 575  Norway rat
AAB52920 481 QAEA---KAQLANPFLATVMILDDDHPGIFQIDEKEMSVTESSGEVEVRIIRTSGARGCVKVPFHSVDGTATYG-KDYEL 556  Doryteuthis opales...
AAB50166 536 -------VK-LAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEG 606  fruit fly
B89047   403 TRIGglpVAQLEMPNTATIMILDDDHAGVFGFEHDHFQVVENCGHLSLQMKRHSGARGKVIIPFRTVEGTASAD-KHFEM 481  Caenorhabditis ele...
Q01728   588 TCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKK------------------------------AL 637  Norway rat
P32418   591 TCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKK------------------------------AL 640  human
AAA97928 588 TCGELEFQNDEIVKIITIRIFDREEYEKECSLSLVLEEPKWIRRGMKA-------------------------------L 636  rabbit
P70549   583 TYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGIS-------------------------------AL 631  Norway rat
P48768   576 ACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-------------------------------AL 624  Norway rat
AAB52920 557 VDKDVIFDNDETEKFLRVRVVDDEEYEKNETFFIWLDEPYLVKKPTG--------------------------------- 603  Doryteuthis opales...
AAB50166 607 ARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDGLa------------------------------AK 656  fruit fly
B89047   482 KEGEIVFEDNQTEALVEIGIVDTEQYERSDYFYIELSPPIWAKKMNDLsriqerfqrrmerkrgssvaseskdsntenAL 561  Caenorhabditis ele...
Q01728   638 LLNElggfTLTegkkmygqpvfrkvha--------rdhpipstvisiseeyDDKQPLTSKEEEERRIAEMGRPILGEHTK 709  Norway rat
P32418   641 LLNElggfTITgkylfgqpvfrkvhar---------ehpilstvitiadeyDDKQPLTSKEEEERRIAEMGRPILGEHTK 711  human
AAA97928 637 LLNElggfTITee-------------------------------------yDDKQPLTSKEEEERRIAEMGRPILGEHTK 679  rabbit
P70549   632 LLSP----EVT------------------------------------------DRKLTMEEEEAKRIAEMGKPVLGEHPK 665  Norway rat
P48768   625 LLNQ------G----------------------------------------DGDRKLTAEEEEAQRIAEMGKPVLGENCR 658  Norway rat
AAB52920 604 -----------------------------------------------------SSSGSVVEDDDPVLAELGKPRRGENIK 630  Doryteuthis opales...
AAB50166 657 IKEV-------------------------------------------------EKKPVQDLTELDRILLLSKPRNGELTT 687  fruit fly
B89047   562 APAEkstrAASvdllqpssdprrssqtnsphltsrfrnrlgswiagmkggnGDDEVTTSLTPSQLEIAEMGKPRLGEFTK 641  Caenorhabditis ele...
Q01728   710 LEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE-DDDDDECG------EEKLPSCFDYVMHFLTVF 782  Norway rat
P32418   712 LEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE-DDDDDECG------EEKLPSCFDYVMHFLTVF 784  human
AAA97928 680 LEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE-DDDDDECG------EEKLPSCFDYVMHFLTVF 752  rabbit
P70549   666 LEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAG-DEEEDESG------EERLPSCFDYVMHFLTVF 738  Norway rat
P48768   659 LEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAG--DEEEDEDGs----rEERLPSCFDYVMHFLTVF 732  Norway rat
AAB52920 631 ITVHIIESTEFKSVVDKLLKKANLSLVVGTSSWREQFIEAITVNAEG-DDDDEEGE------EEKLPSCMDYIMHFVCLF 703  Doryteuthis opales...
AAB50166 688 AYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADeSEFDNDDE------EEEVPSCFSYVSHFVCLF 761  fruit fly
B89047   642 CQITIRESKEFQGIVDRMIKNANTRIMLGTHSWREQFMEALVVSAGDdDDDEGEDGedgeekEPEEPGCMDYVMHVLTVP 721  Caenorhabditis ele...
Q01728   783 WKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYAD 862  Norway rat
P32418   785 WKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYAD 864  human
AAA97928 753 WKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYAD 832  rabbit
P70549   739 WKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYAD 818  Norway rat
P48768   733 WKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCAD 812  Norway rat
AAB52920 704 WKVLFAFVPPTDYWGGWACFTVSIILIGVLTAFIGDLATYFGCTIGLKDAVTAVSFVALGTSVPDTFASKVAAINDKYAD 783  Doryteuthis opales...
AAB50166 762 WKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGAD 841  fruit fly
B89047   722 WKLTFATIPPTDYFGGWATFVVAIFMIGVLTAVVGDLASQFGCWVGLKDAVTAISFVALGTSVPDTFASKVSAVQDKYAD 801  Caenorhabditis ele...
Q01728   863 ASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRR-RPEIGGELGGPRTA 941  Norway rat
P32418   865 ASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRR-RPEIGGELGGPRTA 943  human
AAA97928 833 ASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEHFKVSPGTLAFSVTLFTIFAFINVGVLLYRR-RPEIGGELGGPRTA 911  rabbit
P70549   819 ASIGNVTGSNAVNVFLGIGLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRR-RPHLGGELGGPRGC 897  Norway rat
P48768   813 ASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRR-RPHIGGELGGPRGP 891  Norway rat
AAB52920 784 SSIGNVTGSNAVNVFLGIGIAWSIAAIYHAANGTVFRVDPGTLAFSVTIFCVFAVCTIVLLVCRR-HHLVGGELGGPPRC 862  Doryteuthis opales...
AAB50166 842 NCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVS 921  fruit fly
B89047   802 NAVGNVTGSNAVNVFLGIGIAWSMAAIYHWNQGTKFLVDPGNLGFSVLIFCTEAVLCIIVLVLRR-NKKVGGELGGP--- 877  Caenorhabditis ele...
Q01728   942 KLLTSSLFVLLWLLYIFFSSLEAYCHIKGF 971  Norway rat
P32418   944 KLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 973  human
AAA97928 912 KLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 941  rabbit
P70549   898 KLATTWLFVSLWLLYVLFATLEAYCYIKGF 927  Norway rat
P48768   892 KLATTALFLGLWFLYILFASLEAYCHIRGF 921  Norway rat
AAB52920 863 KYITSGILGSFWVSYLLLTGLMSYCHIPGF 892  Doryteuthis opalescens
AAB50166 922 KYISAAILVFLWVFYVVICILEAYDVIRV- 950  fruit fly
B89047   878 IALRLTIFV----EHNR------------- 890  Caenorhabditis elegans
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