Conserved Protein Domain Family
CCDC106

?
pfam15794: CCDC106 
Coiled-coil domain-containing protein 106
CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.
Statistics
?
PSSM-Id: 464874
Aligned: 7 rows
Threshold Bit Score: 203.52
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_011479210  82 FILVSNLRAHLYVSLEKNSWLQKRIEELEEERNFLRCQLNRFIVSMSPeate------wcgDAQR--------------A 141
XP_006634190  82 MLTITKLQCLLESKQERINFLEKQVEDLQQDRKFLRSQIENLTSAKSI-------------TEDS--------------K 134
XP_002664363 234 QLSLEQAKKTIEIQKEKILHLQEKVDFLMDDRNYLRSRLEDAL------------------RLRC--------------E 281
XP_006005149  81 QMFMTNLRNQLNLTLEKNSWLQKRIEDLEEERDFLRCQLDKFISSTKSda---------vsEYES--------------R 137
PNI14924      20 LALMNSVKAQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARMe-----------aEDHC--------------R 74 
XP_031155399  71 YMVITNLRTQLQISLEKNSWLQKRIEDLEEERDFLRCQLDRFIFSTKSqgqeqsqsqysngYESRrfnwrirreeerpvE 150 pikeperch
XP_019222726   1 ----mteqeevtflkEKLEWQKMRIEELEGERDFLRRQLSSF---------------------TK--------------Q 41  Nile tilapia
XP_011479210 142 VKVQPNCSPS--------------PpspmttrsgmtlkrlqdS------------------------------------- 170
XP_006634190 135 PGKSLYSESK--------------Pr----------------K------------------------------------- 147
XP_002664363 282 TVNSPALTAS--------------Ss---------------tI------------------------------------- 295
XP_006005149 138 MKQNLR-------------------------------------------------------------------------- 143
PNI14924      75 MKPGPRRMEG--------------D-----------------S------------------------------------- 86 
XP_031155399 151 QKTESQHFPSrqfiqrrpgpptmvP-----------------Sknhvsspltnqlasinalfnstqsqallqghshstpn 213 pikeperch
XP_019222726  42 PKDQPFNDPF--------------S-----------------L------------------------------------- 53  Nile tilapia
XP_011479210 171 --GPRTRRNISvpvkqefhikedkyytedeyveeEEEEEAEEEEEDSSVEKG---------------------------- 220
XP_006634190 148 --RSRTASSSS-----------------------SFSNDSGSDISLTTVSSG---------------------------- 174
XP_002664363 296 --VTSQKNQST-----------------------DTSSDSSESTDSSDSEPT---------------------------- 322
XP_006005149 144 ------NGNIS-----------------------DDEDGLGTQSPSSDAGCS---------------------------- 166
PNI14924      87 --RGGAGGEAS-----------------------DPESAASSLSGASEEGSA---------------------------- 113
XP_031155399 214 ttASGSSSNSA------------------------TRASMNEMSGHSNIGPGntndslsllgesdeyleqdsyleeeemi 269 pikeperch
XP_019222726  54 --KASENSDSS-----------------------STFSSVSSVWSSSSSFP----------------------------- 79  Nile tilapia
XP_011479210 221 --------SKKKGRARNAGEPRmkmRRIFRItHGRERQR-VKDPDGVLIRYKKILTTYQRVRSMSRAFQIHGVDRNTMAS 291
XP_006634190 175 --------TSNDGKKKRHHKDK---RRGKKA-KDYSRKR-ATGVQYVIHRYKQVLSAFNKKKSMSGAFRHYGIDRNTIAN 241
XP_002664363 323 --------AKKKKKGKK--SKR---QKKSKT-KMIDIKR-VRTPEDSINRYNKVLQLVRDGLSKAEAYNKVKIDRNTIVK 387
XP_006005149 167 --------ELDRKKLRGRGARG---KQPLRV-KVRDRQR-VKDAEDVLCRYKKILTSFQKLKSMSRAFEYHGVDRNTVAL 233
PNI14924     114 --------SERRRQKQKGGASR---RRFGKP-KARERQR-VKDADGVLCRYKKILGTFQKLKSMSRAFEHHRVDRNTVAL 180
XP_031155399 270 sgedvmqdTINSNRHQLKR------RRVFR--APRERQR-VKDAAGVLFRYKKILLTYQRLKNMSKAFQIHGVDRNTVAS 340 pikeperch
XP_019222726  80 --------KKRKQKYKKKHSRA---KKPKK--EQKKLRQhVQTPNDIVQRYKSPLKTFPRTKTMTKASQKHGLDRNTVVS 146 Nile tilapia
XP_011479210 292 TSPIAELLLVAPEKVSEVGEFEASKEKLLDYARRCYKTM--DEETHAKVQSMKKTHKLLPISY 352
XP_006634190 242 TAPIAELHLAAKEMLQVVGLFHPREETLVKYAQKCAVVIenDENLSRKIEQMKATGELLPITA 304
XP_002664363 388 QAPIAELATANPTEFKSLRATFKKGESVQEFANLCLTRCl-AQSNMEILKQLKESNALLDIFK 449
XP_006005149 234 TTPIAELLIVAPEKVAEIGEFDSSKERLLEYSKRCFMAL--DEETLMKVQALKRNKLLLPISY 294
PNI14924     181 TTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLAL--DDETLKKVQALKKSKLLLPITY 241
XP_031155399 341 TTPIAELLLVAPEKVAEVGEFDPSKEKLLDYARRCYTAL--DEETLSRVQALKKNNLLLPISY 401 pikeperch
XP_019222726 147 TSSVGELAIAVPNVYQELLSNRSSgetvlafakrceaaiqgSDEVKNKIESMKAAGTLLqfee 209 Nile tilapia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap