2CQO


Conserved Protein Domain Family
S1_pNO40
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cd05686: S1_pNO40 
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S1_pNO40: pNO40 , S1-like RNA-binding domain. pNO40 is a nucleolar protein of unknown function with an N-terminal S1 RNA binding domain, a CCHC type zinc finger, and clusters of basic amino acids representing a potential nucleolar targeting signal. pNO40 was identified through a yeast two-hybrid interaction screen of a human kidney cDNA library using the pinin (pnn) protein as bait. pNO40 is thought to play a role in ribosome maturation and/or biogenesis.
Links
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Statistics
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PSSM-Id: 240191
Aligned: 6 rows
Threshold Bit Score: 127.597
Created: 26-Feb-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:RNA binding residues of the RNA PolymeraseII RPB7 subunit, confirmed by mutagenesis
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   #       #          # #                                          
2CQO_A        20 PALYTIFQGEVAMVTDYGAFIKIPGCRKQGLVHrthm-sscRVDKPSEIVDVGDKVWVKLIGRemkndrikVSLS 93  human
AAH84130       5 PELHEIFKGEVASVTEYGAFIKIPGCRRQGLVHkshm-sssHVDRPSEVVDVGEKVWVKVIGRevg--tmgFIIC 76  African clawed frog
NP_956838     16 PPMYSILKGEVVSVTAYGAFVKIPGYRKQGLVHksem-sacRVENPAEIVDVGEQVWIKVIGKemkddkvkLSFS 89  zebrafish
XP_001203156   5 PALYNIYKGEVASIQSYGAFVKLDGYKKNGLVHksqisrtkRVEDVSEVLSVGDIVWSKVISLgede-emkISLS 78  purple urchin
NP_996861      5 PELYAIFQGEVAAVTEYGAFIKIPGCRKQGLVHkthm-sscRIDKPSEVVDVGDKVWVKLIGKemkddklkLSLS 78  chicken
XP_001600416   4 CQVNQIFLGEISSVQNYGAFVKIPGCPQQGLVHrsqv-ssaHVDDVGEVLQRGERIWCKVISIgedg-kiaLSMK 76  jewel wasp

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