Conserved Protein Domain Family
ABC_Metallic_Cations

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cd03235: ABC_Metallic_Cations 
ATP-binding cassette domain of the metal-type transporters.
This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.
Statistics
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PSSM-Id: 213202
Aligned: 45 rows
Threshold Bit Score: 228.957
Created: 26-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P44662        9 WVNDVTVRynnghtaIHNMTFSLNSGt-ICALVGVNGSGKSTLFKSIMGLvkpqqGEIKLcdlpisq--alkrnlVAYVP 85  Haemophilus infl...
NP_395774    20 ELADVAFGyta-tpvVEDISLAVSPGe-YIGVVGPNGSGKSTLMKLMLGLlrpdrGRARLfgvpahq--fdtgsrIGYVA 95  Halobacterium sa...
ZP_00233008   6 EVNNVSYHydk-ehaLENIHFQVTKGs-FTGLIGPNGSGKSTMLKLILGVlkkqqGSISLfgekqad--fkdwvkIGFVS 81  Listeria monocyt...
YP_143719     5 ETQGLAVRfgq-yqaLEDVSLRVPEGs-FVAVVGPNGAGKSTLLKALLGLvp-frGEVRIfgrplg---qadpfwFGYVP 78  Thermus thermoph...
NP_281353     5 EISNLNYAydn-eiiLKNINLSYDNKd-FLSIIGPNGAGKSTLVKLILGLlk-skNEIHFkalq--------rkeIGYVP 73  Campylobacter je...
NP_614998     6 ELKDVWVRygn-qtiLEAVNFELTEPygLLGIIGPNGGGKTTFLKVLLGLlkpykGSVKLfgkppe----ksrdlVGYVP 80  Methanosarcina a...
NP_147305    21 RVEDLTVAyng-epvLSGVNLEFRGPg-LVQIIGPNGAGKTTFLKAILGLikparGRVFLdgfeatgrpemvgryAGYVP 98  Aeropyrum pernix K1
NP_633358     6 ELEDVWVRygn-qiiLEAVNLELKEPngLLGIIGPNGGGKTTLLKVLLGLlkpykGNVKIfgkppe----ksrdlVGYVP 80  Methanosarcina m...
NP_275748     7 EMEDLSYCing-reiLRNINLKVPMGe-LLAVIGPNGGGKTTLLRLITGQikptrGTVRVlgmkpe----dsrsrIGYLP 80  Methanothermobac...
AAV45523     27 ELTDVSFGyts-tpvVEDISVSIDAGe-YVAVVGPNGSGKSTLMQLLLGLlepdsGTAELfgvdata--fddgarVGYVA 102 Haloarcula maris...
P44662       86 Qseev-dwqFPVSVYDVVMMGRygymnflripkaidKQKVQEAMQRVNIEHLAHRQIGELSGGQKKRVFLARALAQQSPI 164 Haemophilus infl...
NP_395774    96 Qhasa-skeMPITVREVVKMGRfphvgfg-qlsaddWAVVDEALDTVGMSAFADRRVTELSGGQRQRAFIARALAGEAEL 173 Halobacterium sa...
ZP_00233008  82 QksnafnsaFPATVKEVVASGLtkkkglfktlnnkdKEDIDYALKRVEMTNYLHRNIGELSGGQQQRVFIARALVSRPEL 161 Listeria monocyt...
YP_143719    79 Qiktf-drtFPALALELVVSGLrrawpf--rvgeeeRRRALEALGRVGALELAHRPLGRLSGGQLQRVYLARALVRRPRL 155 Thermus thermoph...
NP_281353    74 Qhtla-npnFCPRVLEIVLMGLvskkifg-fygkkdKEKAMQALKSVGMEKFWNKTIDSLSGGQRQRVFIARALASECKM 151 Campylobacter je...
NP_614998    81 Qykgf-dfdFPISVWEVVLTGRmshtgflkkysgedKKAAEEALKTVEMFDLKDRQIGQLSGGQRQRVFIARALATNPKL 159 Methanosarcina a...
NP_147305    99 Qnpsa-pklSPMTVREFVETSLrlrgv-----trarERAVEVLHTLGIRGEVLESRLWELSMGMLQRVFIARAIAPDPKM 172 Aeropyrum pernix K1
NP_633358    81 Qyrrf-dfdFPISVWEVVLTGRmshtgflkkyseedKKAAEEALKTVEMFNLKDRQIGQLSGGQRQRVFIARALATKPKL 159 Methanosarcina m...
NP_275748    81 Qrshf-etdFPINILQTVLIGTyrrfea---ptdddRKKALRALKMVGMLEYRDRKIGELSGGELQRVFLARALVREPDL 156 Methanothermobac...
AAV45523    103 Qragt-sreMPITVREVVKMGRfphvgfg-rlsaadWRIVDRAIDTVGMSGFADRRITQLSGGQRQRAFIARALAGEADL 180 Haloarcula maris...
P44662      165 ILLDEPFTGVDVKTENAIVDLLQQLre-eGHLILVSTHNLGSVPDFcDQVVMINRTVIAAG 224 Haemophilus influenzae
NP_395774   174 LVFDEPTVGVDIESVAAFYDLLDVLhd-dGITVVLIEHDLGAVTEHaERVICLNRELHFDG 233 Halobacterium salinarum NRC-1
ZP_00233008 162 LILDEPTVGVDVENVKAFYELLAELnrteEMTLILVTHDLMAVNTYvNHVISINKRIIFDG 222 Listeria monocytogenes str. 1/2a F6854
YP_143719   156 LLLDEPATGVDRLGEVDLYRHLEAYqeetGATILMITHDWEAAHHA-SHVLVLNRRVIGFG 215 Thermus thermophilus HB8
NP_281353   152 LILDEPTASVDNKSAIQIFELLISLhq-kGMGILLICHDINLVLAYsDKIAHLNKELFLHT 211 Campylobacter jejuni subsp. jejuni ...
NP_614998   160 LLLDEPNSGLDPHMQDELYRLLNRLk--hEMAIIMVTHDLSAVSVYvDRIACLNRTFHYHN 218 Methanosarcina acetivorans C2A
NP_147305   173 LVMDEPLASVDPAGRMEIARIIAGLa--rERLVLMTSHDPSLLLGHtDIIVVINRDLIASG 231 Aeropyrum pernix K1
NP_633358   160 LLLDEPNSGLDPHMQDELYRLLNRLk--qEMAIIMVTHDLSAVSVYvDRIACLNRTLHYHN 218 Methanosarcina mazei Go1
NP_275748   157 LLLDEPTASVDPAFRGSFYRIIDELr--dEMTIVIVSHDIGTVARHvDSVACLNHRLFVHG 215 Methanothermobacter thermautotrophi...
AAV45523    181 LVLDEPTVGVDTESVDAFYGLLESLha-eGITVLLIEHDLQAVIEHaERVICLNREIYFDG 240 Haloarcula marismortui ATCC 43049
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