Conserved Protein Domain Family
CFAP300

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pfam14926: CFAP300 
Cilia- and flagella-associated protein 300
CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.
Statistics
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PSSM-Id: 464382
Aligned: 31 rows
Threshold Bit Score: 251.779
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003240265   9 FYHLPKKEPVGLYNKIVQGYL-LKWSMKECLHVHYYAFNQEFL-PDDIDQFALDFFR-DYNVAKNVqaSFS------QFV 79 
XP_001581700   7 FTELDDNGFKTWADKEKMKLInEKWGLNG-IKARTFSYNGELPvPFNPETFFKSFLNt-------------------KGI 66 
XP_002946508   4 FVPVPLPPSSQLTDAFVKSQL-TKWDLLRNMKYMVVRYTKPYH-KMQGQELITDMLN-DPKVQEAF--QVLrsggkwTGL 78 
A8IYS6         4 FVPVSLPSTSALNDAYVKSQL-TKWDLLRNLRCVAVRYTKYYH-KLQGQELLADLFR-DEKVQEAF--QVLrkggawGQL 78  Chlamydomonas r...
XP_001019858  15 SFIFNYVNNEILEEKKIKELF-QKWGLNY-LTVSSYRFNQRFE-EVSAEQFLLEFFN-FPEVRQTLssMNSpk------- 83 
A0CY51        13 SYSFFRQENTILDDKKFMEIL-QKWGLQHSIKVSTFLFDIKFD-HLNPNQFLLDLFN-SKDVRGSLhyV-Sfkq------ 82  Paramecium tetr...
EEY53263      20 FEHLPD-ALPVLRDYEIRQKL-LQWNLSDALHLQRFLVHRRLP-SEADEALLAEFFQ-DHTVHQILplPEHvns---nae 92 
EGF83953     102 FTYLKDAKFPGFDDKETQACL-FKWGMQDHCYIKRFTYDQYLK-PYDIDMFLLDFFNaNPQI------KVQgtmdrwGTL 173
XP_002423656   8 FTHLSSKNFNTLNSKPVIDYL-IKWSIKGQFQLSTFCFNEPYQ-PHDKQKLIDNFFR-DSFVIN----ILNelkpswFFH 80 
XP_008202251   9 FVPLAPRHYMEIENKDTQHYF-GKWGLQGNISIQDFCFNEPFQ-PYNKYHLAERFFK-DQTVANHL---LLkegdswIAK 82 
XP_003240265  80 GSDVA-KVQTESIPCNVTSMTFFDRLLDPNkgIVSCSGSgdddnhaIRQCMEVFKDGMyisNKLKMMLFENECEEYFLYS 158
XP_001581700  67 GSEEVkEVDVEPLSAISIGNKFWKKLWTPPnnICRNATGh-----yINKCPDHHVHGMwlsDCLQVALLDEDSEEYEVFT 141
XP_002946508  79 GGRVT-RVDANVVTASLTRLDIFDKLNESSpaIVRPNGD-------IAKCMDNVREGFqisDLLRDLLLNEDSENAGLYS 150
A8IYS6        79 GGPVT-KVDATLLASSLTRMDLFDKLTETSppIVRSNGD-------IGKCMEDNREGFqvsDQLRELILVEESEHAALFS 150 Chlamydomonas r...
XP_001019858  84 -enYS-TIKYKRLKVNQIKMDLFDRLEENN--LVVK-DM-------IKQTYEDFVEEIqinDLVRECLIKEESEHYEIFS 151
A0CY51        83 nvlLS-QIKFQPLTCKSIKLDLFDKLTEDK--IVVK-GH-------IKQCFEEQFENIqiaDELRKALVLEDSEQYCVFN 151 Paramecium tetr...
EEY53263      93 SSSKAfSLHFERLRVSVTSLAFFEKLESAG--IVARDGS-------VRGCIDEDFDGCtagDLLTEMLVNPDSDNCDVFS 163
EGF83953     174 G-NVT-NVSKEETNHTITSLDFFDRLLTNG--IVRSNGQ-------ITKCMDEYHDSFlvaDNLRKCLLMPEFDLYDLFS 242
XP_002423656  81 KEDID-HVYTEIVPCTISSMTFFDRILKEEnkIIRIDGV-------IRNCLDDYKNGFliaDELRKMILDEESDNYSLYL 152
XP_008202251  83 GIKAS-SIEVTAVPCFVLNMSFFDKLLDPAnkIVHNSGV-------TCKRFDTDIEGFtvsDNLRGMILDEYCEEYQLFN 154
XP_003240265 159 EDERSEFMFRLLQHFST-GGQWCQDDVVIEPYLNAMKYVYKDLL--AVEK------IPGSG-IQVSSKVYKVVAF--DSN 226
XP_001581700 142 PEDRRELLFHVIKLLVL-GGEICQYEDEWDTYEPVITSLYRDLIgqSVVK-------NTSGaISIVARPYLLKKT--NGK 211
XP_002946508 151 AEERDELLWRLFEHMVL-GGSCCQFEDKLEPYVETSKRLYKELV--SALK------DPGTGkIHVASVVYKVNAVhgESG 221
A8IYS6       151 EAERDELLWRLFEHVVL-GGACCQFEDKVEPYVETSKRLYKELV--CAQK------DPATGkVQTVSAVYKINSIqgDSG 221 Chlamydomonas r...
XP_001019858 152 EEDRKQFLFRLFQLVVL-GGQMCQWEEKLSIYLDATKHLYKNLV--TARK------DSATDnIYIDSFVYEIQAL--DKS 220
A0CY51       152 EADRQELLFKLFQILVL-GGQLCQYEDEIQAYLDWTKYLYKNTV--NARK------YADKDeIYIDSYAYDIRKL--ENS 220 Paramecium tetr...
EEY53263     164 EQDKQEFIFLLFSTLIIgGGALRQADSRVQAYENVTRELYH---------------------IEITSRVYRVSGD----- 217
EGF83953     243 PDDRREFIFHVFQAMCL-GGRLCQYENDLEPYLQVTKKLYKDLI--TVVK------DPLTNkLKVASFIYKITQV--KSS 311
XP_002423656 153 ENDRNELIFRIFKFLIL-GGQWCQFEDKINPYLDVTKILYKDLV--HVEK------NPETKkIEIKSICLKVTIM--GKN 221
XP_008202251 155 SEERAEFIFRIFEMLVL-GGSLCQFEEELQPYLDTTKKIYKELV--RVQKrrqqeqQGANRdLSIGTTVLQVVAK--NER 229
XP_003240265 227 NtVLFPKECRNliPYSFAYLAVNPKTRTVALFFH 260
XP_001581700 212 SiLGNP-------DHSACILVIDTVGKKVRMLQY 238
XP_002946508 222 PlELFPSKS----RQNFCYVSMDPSRRLAKILYH 251
A8IYS6       222 PlELYPSRS----RQNFCYAAVDPVRRIVKILYH 251 Chlamydomonas reinhardtii
XP_001019858 221 ----YKKG-NN--PQDVLYVVVNPSIRMLHVVQN 247
A0CY51       221 ----YSSDH----PQNVMYVVVNPSLRIVNIIEN 246 Paramecium tetraurelia
EEY53263     218 --ALFHAS-LS--RFHSCFAIVDARKRWLTVWYC 246
EGF83953     312 VsQLFPL--EH--PQNFCYVSIDPMRRHINLLYH 341
XP_002423656 222 KkSIFPIDGDH--IQNFLYVIIDPKKGRLHYFYM 253
XP_008202251 230 GeAFYPANPEH--RQNIGFLLIDGSNRQITTLLH 261
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