1CW3,1BXS


Conserved Protein Domain Family
ALDH_F1AB_F2_RALDH1
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cd07141: ALDH_F1AB_F2_RALDH1 
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NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
NAD+-dependent retinal dehydrogenase 1 (RALDH 1, ALDH1, EC=1.2.1.36) also known as aldehyde dehydrogenase family 1 member A1 (ALDH1A1) in humans, is a homotetrameric, cytosolic enzyme that catalyzes the oxidation of retinaldehyde to retinoic acid. Human ALDH1B1 and ALDH2 are also in this cluster; both are mitochrondrial homotetramers which play important roles in acetaldehyde oxidation; ALDH1B1 in response to UV light exposure and ALDH2 during ethanol metabolism.
Links
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Statistics
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PSSM-Id: 143459
Aligned: 18 rows
Threshold Bit Score: 863.966
Created: 2-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:1CW3; Human mitochondrial aldehyde dehydrogenase (ALDH2) complexed with NAD+ and Mn2+, defined using 3.5 A.
  • Structure:1BXS; Sheep liver cytosolic aldehyde dehydrogenase (ALDH1) complexed with NAD+, defined using 3.5 A.
  • Citation:PMID 9195888
  • Citation:PMID 9862807
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1CW3_A         8 QPEVFCNQIFINNEWHDAVSRKTFpTVNPSTGEVICQVAEGDKeDVDKAVKAARAAFQLGSPWRrMDASHRGRLLNRLAD 87  human
AAP35081       3 QVEVKYTQIFINNEWHDSISGKTFeTINPFTEEKLANVQEGDKaDIDRAVVAAVDAFRFDSPWRqMDASQRGHLLYRLAD 82  American house ...
NP_001040198   3 KVDVKYTKLFINNEWVDAVSKKTFpTINPQDETVITQVAEGDKaDIDLAVAAAKKAFHRYSPWRtMDASQRGLLLLKLAE 82  domestic silkworm
XP_786787     39 NPDIQHHKLFINNEWVNSVSGKTFpTINPATEEVIAEVAEADKaDVELAHAAASEAFRLGSPWRtTNASRRGALINKLAD 118 purple urchin
XP_002128130   9 KPKIQYTQIFINNEWRNSISGKTFaTINPCTEEKICDIQEGDKaDVDLAVKAASEAFKLGSPWRtMDASQRGVLLNKLAD 88  Ciona intestinalis
AAF73122       7 NPEIRYKQLFINNEWVNAASGKTFpVINPATGKKIVDIQEGDKaDVDKAVAAAKRAFEPGSVWRnTDASDRGRLLNKLAD 86  sea scallop
XP_001637601  10 NPQIKYTKLFINNEFVDCTSGKVFpTINPTTGEKICDISEGDKeDVDKAVKAAKEAFKLGSAWRtMDASMRGKLLYKLAQ 89  starlet sea ane...
XP_002110539   8 NPEIKYTKIFINNEWHDSVSGKTFpTFNPATGEKICDIAEGDKaDIDLAVAAAKQAFKKGSTWRtMDASKRGRLISKLAE 87  Trichoplax adha...
Q27640        12 DLKVEFTKIFINNEFVDSVSGKTFaTINPSTGEKLAEVQEGDKaDIDKAVAAARAAFKRDAEYRkHDASDRGRLLFKLAD 91  Enchytraeus buc...
XP_001603449  10 NPEIKYTKLFINNEWVDSVSGKKFtTINPANEKVIAEVSEAEKaDVDKAVKVARAAFERGSVWRnLDASARGRLIYNLAQ 89  jewel wasp

Feature 1                                                                               ####     
1CW3_A        88 LIERDRTYLAALETLDNGKpyviSYLVDLDMVLKCLRYYAGWADKYhGKTIPiDGDFFSYTRHEPVGVCGQIIPWNFPLL 167 human
AAP35081      83 LIERDQDYIASLESMDNGKpk-tMALFDVDLAIKVFRYYAGYADKIhGKTIPaDGKVFAFTRIEPVGICGQIVPWNFPFL 161 American house ...
NP_001040198  83 LLESQSRYLAELETLDCGKpv-kQSEEEVYFSASVLRYYAGKADKIlGNTIPsDGEVLTFTMKEPVGVCGQIIPWNYPIP 161 domestic silkworm
XP_786787    119 LVERDWAHLASLETLDNGKpyqdSYTIDVPGVLATLRYFAGWADKIeGKTIPvDGDFMTYTRHEPVGVCGQIIPWNFPLL 198 purple urchin
XP_002128130  89 LINRDRHILASLETLDNGKpynvSYNVDLELVIRCYRYYAGFADKNhGKLIPmDGNAHAYTRHEPVGVCGQIIPWNFPLL 168 Ciona intestinalis
AAF73122      87 LIERDRQYIASLESLDNGKpfsdSFNVDMVLVCKCLRYYAGWTDKIcGKTIPmDGNFFCYTKLEPVGVCGQIIPWNFPLL 166 sea scallop
XP_001637601  90 LIDRDIAYLASLETIDSGKlf-sDSVGDMQSSANCFRYYAGWADKVtGKTIPaDGPYFVYTRHEPVGLVGAITPWNFPLN 168 starlet sea ane...
XP_002110539  88 LMERDQQYLASLESLDNGKpvrvANFADLPGAMLCFRYYAGWADKIhGKTIPvDGPYMTYTRHEPIGICGQIIPWNFPLL 167 Trichoplax adha...
Q27640        92 LIEAHRVQLRTLETLDNGKpfamSYLGDTLMAQKVLRYYAGFADKIvGQTIPaDGNVFCYTRHEPVGVVGAITPWNFPLH 171 Enchytraeus buc...
XP_001603449  90 LIEDHVNEIASLESLDNGKpf-nNSYYQTLESTNVLRYFAGCADKIhGLTIPsDGKEFALTRKEPVGVVGAIIPWNYPII 168 jewel wasp

Feature 1                          #  #                             #   ##            #  #  #    
1CW3_A       168 MQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGpTAGAAIASHEDVDKVAFTGSTEIGRVI 247 human
AAP35081     162 MASWKFGPALCAGNTVVLKPAEQTPLSALYLASLTKEGGFPPGVVNVVPGFGeTAGAALVDNPKVDKIAFTGSTEIGKLI 241 American house ...
NP_001040198 162 MMSWKIAPALAAGCTVVLKPAEQTPLTALAVAALVKEAGFPPGVVNVVPGYGaTAGGALTHHPDVDKIAFTGSTEVGRII 241 domestic silkworm
XP_786787    199 MLAWKWAPALACGNTIIMKTAEQTPLTALHMAELAKEAGFPPGVINVLSGYGpTAGAAIASHPGIDKVAFTGSTEIGRII 278 purple urchin
XP_002128130 169 MQAWKLGPALSMGNVVVMKPAEQTPLTALYVAALIKEAGFPPGVVNMIPGYGpTAGAAISEHMDVDKVAFTGSTEVGHLI 248 Ciona intestinalis
AAF73122     167 MLAWKIGPAIACGNVVVLKPAEQTPLTALYTAALTKEAGFPPGVVNMIPGYGpTAGAAISEHYDVDKVAFTGSTEVGQIV 246 sea scallop
XP_001637601 169 MASVKIAPALACGNVVILKPAEQTPLTALYFCALVKEAGFPAGVVNVIPGYGpTAGAAITTHLDIDKVSFTGSTEVGRLI 248 starlet sea ane...
XP_002110539 168 MASWKLAPALACGNVVVLKPAEQTPLSVLYLCQLAVEAGFPPGVINVVPGYGpTAGAAISNHPDIDKVAFTGSTEVGQII 247 Trichoplax adha...
Q27640       172 LAASKIAPAIAAGCTLVLKPAEQTPLTALYLASLVKQAGFPAGVINIVPGLGhTAGAALTNHPDINKITFTGSTEVGQLI 251 Enchytraeus buc...
XP_001603449 169 LLSFKLGMALAAGCTVVVKPAEQTPLTALYVASLVKEAGFPPGVVNVLPGYGpSTGAAISSHPDIDKVSFTGSSVVGKAI 248 jewel wasp

Feature 1                       ##                                #                              
1CW3_A       248 QVAAGssNLKRVTLELGGKSPNIIMSDa-DMDWAVEQAHFALFFNqGQCCCAGSRTFVQedIYDEFVERSVARAKSRvvG 326 human
AAP35081     242 MRNGSh-SMKRITLELGGKSPLVVTENveDIAQAARTAQDSCFLNmGQCCCAGTRTFVHesIYDEFVKHSVEYCQSHvfG 320 American house ...
NP_001040198 242 LGAASavNLKRVTLELGGKSPLVVFNDa-DVEKAAQIAHAAAFANaGQCCCAGTRTYVQsgIYDKFVKKAAEIAEKRsvG 320 domestic silkworm
XP_786787    279 AQSAGasNLKKVTLELGGKSPNIILADa-DLDHAVEQSHSAIFWNmGQACCAGSRTFVEdkIYDEFVERSVERAKSKvvG 357 purple urchin
XP_002128130 249 MQAAGksNLKRVTLELGGKSPNIIFEDa-DLDYAVEMAHFGLFFNmGQCCCAGSRVFVQesIYDEFVKKSVARAKKRtvG 327 Ciona intestinalis
AAF73122     247 MQAAArtNLKRVTLELGGKSPNVVFSDa-DLDIAVEACHNGLFFNmGQCCCAASRTYVQedIYDVFTKKLVEKAKTRvvG 325 sea scallop
XP_001637601 249 QEASAksNLKRLTLELGGKSPNIVFADs-DMDYAVEMAHEALFFNqGQCCSAGSRTFVQdtIYDEFVKKSVKRAKARtvG 327 starlet sea ane...
XP_002110539 248 AQAVGasNLKKISLELGGKSPNIIFDDv-DVDEALQWAHLGVFFNnGQCCTAGSRVFVQdaIYDEFVAKAVAKAKTVrvG 326 Trichoplax adha...
Q27640       252 IQGSGktNLKRVTLELGGKSPNIIFPDs-DLDYAVEVSHQAIMANmGQVCCAGSRTFVHedIYEEFVRRSVERAKKRtvG 330 Enchytraeus buc...
XP_001603449 249 LEASAksNLKKVSLELGGKSPLVVFNDa-NLELALKYASDALFVNaGQTCIAPTRVFVQsgVYDKFTKRFVEIASKVkvG 327 jewel wasp

Feature 1                        #  #                                              #             
1CW3_A       327 NPFdsktEQGPQVDETQFKKILGYINTGKqEGAKLLCGGGIaadRGYFIQPTVFGDVqdgMTIAKEEIFGPVMQILKFKt 406 human
AAP35081     321 NPFdsktAFGPQVDKIQMNRILEMIESGKqEGARCVAGGNRmdkRGYFVEPTVFADVtdgMRIAREEIFGPVQQILKYKt 400 American house ...
NP_001040198 321 NPFdd-vQQGPQIDEEMYKKVLNYIVAGKeGGARCVAGGDKvgdKGYYIKPTVFADVqddMKIAREEIFGPVQSILKFEt 399 domestic silkworm
XP_786787    358 DPFdmskDQGPQINDEQFKKILGLIESGKsDGAKLATGGGRhgdKGYYIQPTVFTDVkddMKIAREEIFGPVQSIFKFSe 437 purple urchin
XP_002128130 328 SPFetgvEQGPQVDAEQFKKIQELIQSGKdEGAELLCGGERhgdKGYYIQPTVFGNVkdhMRIATEEIFGPVQQIMKFKt 407 Ciona intestinalis
AAF73122     326 DPFdsrsMSGPQVDQEQFDKILALIDSGVqQGAKLECGGKRhgnVGYFVQPTVFSGVtedMRIGKEEIFGPVQQIIKFKt 405 sea scallop
XP_001637601 328 DPFds-vEQGPQIDQEQFDKIMDLIESGKkEGAKMQCGGARhgnKGFFIQPTVFSDVtddMRIAKEEIFGPVQQLIKFKs 406 starlet sea ane...
XP_002110539 327 NPFdd-iDQGPQIDEEQMKKILELIDSGKaEGADMKCGGSRhgdRGYFIQPTVFTDVkddMRFAKEEIFGPVMQIFKFSt 405 Trichoplax adha...
Q27640       331 DPFdpknENGPQVDETQLKKILELIESGKtEGAKLECGGKRlgdKGYFVEPTVFTDVtssMRVAKEEIFGPVQLIFKFKd 410 Enchytraeus buc...
XP_001603449 328 DAFepgvFQGPQIDTKGFNKVLSLIETGKkEGAKCEIGGKRrgnVGYFVEPTVFTNVsddMTIAKEEIFGPVQSIFKFEt 407 jewel wasp

Feature 1                                                                                        
1CW3_A       407 IEEVVGRANNSTYGLAAAVFTKDLDKANYLSQaLQAGTVWVNCYd--vFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKT 484 human
AAP35081     401 LDEVIERCNDTNYGLGSAILTNDINEAMKFSRsIRAGSVWINIPymipVSVQTPFGGFKESGVGRELGEDGLRGYGEIKT 480 American house ...
NP_001040198 400 FDEVVDRANDTNYGLAAGIITNDITVAMSFSKhVRAGSIWINTYe--hVTTQTPFGGFKDSGLGRELGEDGISQYLETKT 477 domestic silkworm
XP_786787    438 MNEVINRANNTEYGLAAAVFTKDIDKALYVSNsLRAGTVWINCYn--vVSPMAPFGGYKMSGTGRELGEYGLEAYTEVKT 515 purple urchin
XP_002128130 408 MEEVIERANNTVYGLAAAVFTKDLNTAITVSNsVRAGTVWVNTFn--sFSSMTPFGGYKMSGQGRELGEYGLANYTEVKC 485 Ciona intestinalis
AAF73122     406 MEEVVQRANKTTYGLAAAICTKDIDKVMTYSSqVKAGTVWVNSFn--vFGAQCPFGGFKMSGIGRELGESGLQQYSEVKT 483 sea scallop
XP_001637601 407 VDEVIERANNTTYGLAAGVFTKNIDTAIAVSSgLRAGTVWINCYe--cGAPQAPFGGYKMSGYGREWGEYGVLPYCEVKT 484 starlet sea ane...
XP_002110539 406 IDEVIERANNTVYGLAAAVFTKDIKRAIHVSNhIRAGTVWINCYh--mTACQAPFGGYKMSGFGRELGEYGLELYSEVKT 483 Trichoplax adha...
Q27640       411 VDEVIERANDTSYGLAAAVFTKNIDTALKVANsLEAGTVWVNTYn--hFAFQAPFGGYKMSGQGREFGHYGLEAFLEVKT 488 Enchytraeus buc...
XP_001603449 408 LDEVIKRANNTPYGLSAGVFTENLNTALEFSKaVQAGTVWVNQWg--aVHPQTPFGGYKTSGLGREMGIGSLDEYLETKT 485 jewel wasp

Feature 1            
1CW3_A       485 VTVK 488 human
AAP35081     481 VVIM 484 American house dust mite
NP_001040198 478 ITMH 481 domestic silkworm
XP_786787    516 VTVK 519 purple urchin
XP_002128130 486 VIIK 489 Ciona intestinalis
AAF73122     484 IIIK 487 sea scallop
XP_001637601 485 VTMK 488 starlet sea anemone
XP_002110539 484 VTIA 487 Trichoplax adhaerens
Q27640       489 VYVR 492 Enchytraeus buchholzi
XP_001603449 486 INIS 489 jewel wasp

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