2B67,4QLY


Conserved Protein Domain Family
MhqN-like
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cd02137: MhqN-like 
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nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN
A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.
Links
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Statistics
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PSSM-Id: 380314
Aligned: 24 rows
Threshold Bit Score: 145.076
Created: 13-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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FMN bindingdimer interface
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:FMN binding site [chemical binding site]
Evidence:
  • Structure:2B67: A Streptococcus pneumoniae nitroreductase homodimer binds 2 molecules of FMN, contacts at 4A
    - View structure with Cn3D
  • Comment:binding involves contacts from two monomers
  • Citation:PMID 9654450
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   ###                         #####                                         
2B67_D              7 LELNKKRHATKHFTdk-lvDPKDVRTAIEIATLAPSAHNSQPWKFVVVR-------------EKNAELAKLayg------ 66  Streptococ...
NP_870033           4 KDAIFNRRAIKHFDaehkmTAAEEKELLETTIQAPTSFNIQHWRFVILRd-----------pELRAKIRKDfg------- 65  Rhodopirel...
CAD14523           14 QALNGRRRAIRDFDgi-aiPDEHVRELLAEAARAPSSGNLQPYRFHWIRd-----------tTLKARVAAVcn------- 74  Ralstonia ...
CAH08878            4 EEVLNYRRSVRVFDktkplDPEKVKHCLELATLAPNSSNMQLWEFYQVIq-----------pELLAKISKAcl------- 65  Bacteroide...
Q55233              4 FDAIYQRRSVKHFDpdhrlTAEEERKLHEAAIQAPTSFNIQLWRFLIIRd-----------pQLRQTIREKyg------- 65  Synechocys...
YP_236020          15 ADLIKSRISANNYDterklSDQAITDLIDLATHAPSAFNLQNWRFVAIRs-----------eEAKARLLPLay------- 76  Pseudomona...
AAK02245            4 SELLHHRRAVRYFDpdkplDSEKVTQCLQLATLAPSSSNMQLYEFYHITd-----------kALLAQLATAcl------- 65  Pasteurell...
YP_003316901        4 REAIRSRRSINFFDpgrriPEGVLEEVIEEANLAPSSFNLQPWEVVVVKd-----------pEDKRRLRECaf------- 65  Thermanaer...
NP_831975           7 KEVIHGRRSVRKFTdq-evSTNDIKEIIDCARYAPSDTNSQTWEFLVIMnrekikeieqmtwDALHKLAAKaaengeeka 85  Bacillus c...
PBRC:IHMA87_05673   4 EEAVRSRRAIKGYDpsfslSREEKDHLLDLALHAPSAFNLQHVRLVEVSd-----------pQLRAQLREVaw------- 65 

Feature 1                    #                                                                        
2B67_D             67 ---snFEQVSSAPVTIALFTDTdlakrarkiarvggannfseeqlq---------------------------------- 109 Streptococ...
NP_870033          66 ---ndQPQMTDASLLVLFTADMkawqkepsryfanapkevaeml------------------------------------ 106 Rhodopirel...
CAD14523           75 ----gQRAAVSASTLIVVTASRkialstaaqqlaylnastdlpeaskayhrkqmqmflril--------nvgswpvwtpl 142 Ralstonia ...
CAH08878           66 ----dQTATSTASEVVVFVTRQdlyrirakfvldfergnvrrnspkerqekrikdrelyygklmpflyarffrilgllrs 141 Bacteroide...
Q55233             66 ----nQAQMTDASLLILVAADVnawdkdparywrnaprevanyl------------------------------------ 105 Synechocys...
YP_236020          77 ----gQKKVVDSAVTFIVCGTLnphqtiatslkpsmdagvidkaiy---------------------------------- 118 Pseudomona...
AAK02245           66 ----gQQTATTAQQMVVFVTRQdlykqraqavlafesenikrhsppdr-------------------------------- 109 Pasteurell...
YP_003316901       66 ----nQPKVEEASAVLIVASDPmaverhidrvlksmvelgymkaedv--------------------------------- 108 Thermanaer...
NP_831975          86 gklltRSFGPYATAFSEAPVLIvclatpyeskfrekifd----------------------------------------- 124 Bacillus c...
PBRC:IHMA87_05673  66 ----nQAQVTDAAMLVVVCAQLdswernaqrvwdgapeavqafm------------------------------------ 105

Feature 1                                        #  #                #####                      #     
2B67_D            110 ---yfxknlpaefaryseqqvsdylalNAGLVAXNLVLALTDQGIGSNIILGFDk---SKVNEVLEIEdRFRPELLITVG 183 Streptococ...
NP_870033         107 ------vnwmgpfhegrewlqrdeaqrSIGLTMQTMMLAAQGMGYQSCPMIGFDi---EEVAKLINLPdDHVMGPMVAIG 177 Rhodopirel...
CAD14523          143 talaglfrpslsllpvghlgnrswaarNATFAAQTLMLAAAAKGVDSCPMEGFSa---PKLVEILSLPrGTVIPLVIALG 219 Ralstonia ...
CAH08878          142 vlakaiglfrpivrevsesdmrvvvhkSCALAAQTFMIAMANEGYDTCPLEGFDs---KQMKKLLKLPhGAEVNMVIACG 218 Bacteroide...
Q55233            106 ------vgaiasfyggkpqlqrdeaqrSIGMAMQNLMLAAKAMGYDSCPMIGFDl---QKVAELVKLPaDYAIGPMVAIG 176 Synechocys...
YP_236020         119 ---dmwvgavqgmyaenpqlqrdeairSGSLAAMTLMLAAKGQGLDSTPMIGFDp---AAVAEAFNLSaTEIPVMLVTVG 192 Pseudomona...
AAK02245          110 --wenrlkgktlyyaklmpfiyarcfgLLGLFRKGLAYAIRLFRPVSTEVSEADv--rVVVHKSCGLAaQTFMLLMAEQG 185 Pasteurell...
YP_003316901      109 --ertrpmpfnlygemdserrrlfavkNASLFAMSLMIAAMGHGLSTHPMDGFNe---SKVKEAFGIPgRFVIPMLIAVG 183 Thermanaer...
NP_831975         125 -----------piafvpnsvweeegikSSCLAAQNLMLAAHAKGLGTCPMTGPVllaqDELRQYLQVEpEKQINMVISLG 193 Bacillus c...
PBRC:IHMA87_05673 106 ------agaidtyyrgkpqvqrdeamrSCGLLAQTLMLVARGQGLDSCPMDGFDf---DAVARLINLPdNHVIGLMVAVG 176

Feature 1                        # #      
2B67_D            184 Ytdek---lepSYRLPVDEI 200 Streptococcus pneumoniae TIGR4
NP_870033         178 Kgtke--awpkPGQLTLDEV 195 Rhodopirellula baltica SH 1
CAD14523          220 Yrsqna-rierQWRRSLTDL 238 Ralstonia solanacearum
CAH08878          219 IrdgnkgiwgeRGRVPFDEV 238 Bacteroides fragilis NCTC 9343
Q55233            177 Krte----dapGKRRSNSPG 192 Synechocystis sp. PCC 6803
YP_236020         193 Ypges--nwpqKPRKAVREV 210 Pseudomonas syringae pv. syringae B728a
AAK02245          186 Ydtcpi-egldGGKVKKLLS 204 Pasteurella multocida subsp. multocida str. Pm70
YP_003316901      184 YlrdgvtllprGLRRPLEEF 203 Thermanaerovibrio acidaminovorans
NP_831975         194 Fpkdk---pkkLPRKEVDEI 210 Bacillus cereus ATCC 14579
PBRC:IHMA87_05673 177 Rkave--pwprTGKLPREEL 194

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