6016146 55 RETLLKNVEDiSKFDVLIIGGGATGTGVAVDASTRGLNVCLLEKTDFASETSSKSTKMAHGGVRYLEKavFQLSkaqldl 134 fission yeast 1169945 6 SIYKDVGDLSsLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRNHGLLHSGARYAVN--DQES------ 77 Haemophilus influenzae 15603307 6 QMYKSTADTSpMTTDVIIIGGGATGAGIARDCALRGVNCVLLERRDIATGATGRNHGLLHSGARYAVN--DPES------ 77 Pasteurella multocida 15899261 5 LMLNPLHIIMeIKSTVTVIGGGVSGLFTALDLALRGIDVTLVDRGDIGYGTSGKFHGLLHSGARYAVT--DPDS------ 76 Sulfolobus solfatar... 13541671 1 ------------MEKIAVVGAGITGLFTAYYLSASGFDVEVFDKGDIASGTSGKFHGMLHSGARYAVT--DKVS------ 60 Thermoplasma volcanium 16081722 1 --------MMsMSEKIAVIGAGINGIFAAYYLAYAGYDVTVFERGDIDSGTSGRFHGMLHSGARYATN--DEVS------ 64 Thermoplasma acidop... 15601502 1 -----MTAYQrMETDVVIIGGGATGTGILRDCALRGLRCILVEKDDIAAGTTGRNHGLLHSGARYAVT--DSES------ 67 Vibrio cholerae 16554483 1 ---------MtHQTDVLVVGGGATGVGVARDLALRGVDVTLVDRGGLGSGTTGRSHGLLHSGARYADS--TPAD------ 63 Halobacterium sp. N... 15790842 1 ---------MaQEPHVVVVGGGSTGAGVARDLAMRGLGVTLVEQGNLTHGTTGRMHGLLHSGGRYAVS--DQAS------ 63 Halobacterium sp. N... 16123961 1 ----MTNSSPyLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGARYAVT--DGES------ 68 Yersinia pestis
6016146 135 VIEALNERANMLRTAPHLCTVLPIMIPVYKwWQVPYFFVGCKIYDWVAGsknlrASTIFSKeTTVAIAPMLDDSNLKaSC 214 fission yeast 1169945 78 AEECIKENRILRKIARHCVDETEGLFITLP-EDSLDYQKTFLESCAKSGi---dAQAIDPE-LAKIMEPSVNPDLVG-AV 151 Haemophilus influenzae 15603307 78 AKECIEENKILRRIARHCVDETEGLFITLP-EDDLSYQKQFIQSCTQAGi---dAIAIDPD-LAKHLEPSVNPDLVG-AV 151 Pasteurella multocida 15899261 77 ARECIQENKIISKIAPHTVKDTGGVFLGIT-DDDLQFSETFIKALNKVGi---eSKVIDVK-EVLQKEPFINRDTKM-AI 150 Sulfolobus solfatar... 13541671 61 ASECISENNTISSFARWFINDTGGYFVSSN-REESDYGDTLTKACNDAGi---pNYDIDVD-EFKKIEPNV-KNVDR-VI 133 Thermoplasma volcanium 16081722 65 ARECIVENRRISNIGHRYVENTGGYFLAAN-DDEAEFGDVLFDACRRAGi---dISEIPIE-EFARDNPQL-KNARR-AM 137 Thermoplasma acidop... 15601502 68 ARECIQENKILKSIARRCVEATDGLFITLP-EDDLGFQESFIHACSDAGi---eTQRLTPK-EALLLEPNVNPALIG-AV 141 Vibrio cholerae 16554483 64 ARECIRENEVLRDIAGACIRDTDGFFVQHA-RDDPAYFDTKVAACRDADi---pVSVIDGA-TARAREPALTPAAER-VA 137 Halobacterium sp. N... 15790842 64 ARECIIENRVLREIATHCVDETGGLFVKRP-EDSEQYFQEKLAGCEACDi---pTKVLSGA-EARQLEPHLADDVEK-AI 137 Halobacterium sp. N... 16123961 69 ARECIEENRILKRIARHCIEQTDGLFITLP-EDSLAYQLQFIARCRDAGi---eAEAIDPA-QALRLEPAVNPALIA-AV 142 Yersinia pestis
6016146 215 VYHDGSFNDTRMNTTLAVTAIDNGATVLNYMEVKKLLKSKDnkLEGVLAIDRET---------GKEYQIKATSVVNATGP 285 fission yeast 1169945 152 VVPDGSIDPFRLTASNMMDATENGAKMFTYCEVKNLIREGGk-VIGVNAYDHKn---------RRERQFFAPLVVNAGGI 221 Haemophilus influenzae 15603307 152 VVPDGSIDPFRLTASNMLDATENGARIFTYCEVKNLIQEGGr-VIGVSVYDHKy---------KINRQFFAPVVVNASGI 221 Pasteurella multocida 15899261 151 WVPDKVVYGYDLLASVAITASLNGAKILTYNEVVEIIRENNn-VKGVKVLDKIn---------NNTNVIKSDIIVNTAGP 220 Sulfolobus solfatar... 13541671 134 HVPDKVIRAYEFSAAVAAEAFMNGTKFRLYSPVASVSEKGGkyVLGIE----Rn---------GSLHYEHFDLIVNATGP 200 Thermoplasma volcanium 16081722 138 RVPDKVIRSYEFVVSVAAAAHLMGTKIRTYSDVKKIDIEGNs-VTGIEYE--Rs---------GKEISEKFDAVVNATGP 205 Thermoplasma acidop... 15601502 142 KVPDGTLDPFRLCAANVLDAKEHGARMFNRTIVTQLIREGDt-VLGVRCQHLGs---------GAKFDIFAQQVINAAGI 211 Vibrio cholerae 16554483 138 VVPDGVVLPSRLVAATAADARDHGATIRLHEPITALTTDAGr-VTGARTADGT--------------TLSATHVVNAAGA 202 Halobacterium sp. N... 15790842 138 WVPDAAIDPFRLVVANAASAQEHGARIETHSTVTDVVVEDGa-VVGVEVEHATGagkrvhgteGGTEVIRADHVVNAAGA 216 Halobacterium sp. N... 16123961 143 RVPDGTVDPFRLTAANMLDAREHGANILTYHEVIGLLRQGSr-INGVCVFDHKn---------QRKYDIHAQIVVNAAGI 212 Yersinia pestis
6016146 286 FSDKILEMDADPQgeppktaqfpRMVVPSAGVHVVLPEyycPPNIGILDPSTSDNRVMFFLPWQGKVIAGTTDKPLSS-V 364 fission yeast 1169945 222 WGQGIAEYADLK-----------IKMFPAKGALLVMGH---RINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYdQ 287 Haemophilus influenzae 15603307 222 WGQGIAAYADLN-----------IRMFPAKGALLVMGH---RINKMVINRCRKPADADILVPGDTICVIGTTSSRIPYdQ 287 Pasteurella multocida 15899261 221 WSFNIIKMAGLEE----------IPIMPTAGIIVVFDK---RVNNMVINRLRPPSDGDIIVPYADSSILGTTATIIED-- 285 Sulfolobus solfatar... 13541671 201 FSGEFLKLAGYGG----------SPVMPSAGIMVVFSK---PIVRSIINRMREPSDADIMVPYDGLSILGTSAVIVDD-- 265 Thermoplasma volcanium 16081722 206 FSGKILERSGLKQ----------TPVMPSAGIMVVLEG---RVSTAILNRMREPSDADILLPYWSNSILGTSAVVVED-- 270 Thermoplasma acidop... 15601502 212 WGQNICEYADLN-----------IKMFPAKGSLLILDY---RINNLVINRCRKPSDADILVPGDTISLIGTTSEHIDYdQ 277 Vibrio cholerae 16554483 203 WAGDLAATAGVD-----------VDMHPASGVMVTVET---PETDTVFNRCRPAADGDIVVPHGSTAVLGTTSVDVDD-- 266 Halobacterium sp. N... 15790842 217 WAGRLGEMAGVD-----------VEVRPSKGVMTVMNT---RQVDTVVNRCRPKGDADIVVPHETTCILGTTDEEVAD-- 280 Halobacterium sp. N... 16123961 213 WGQHIAEYADLR-----------IRMFPAKGALLILGH---RINNMVINRCRKPADADILVPGDTISLIGTTSTHINYdQ 278 Yersinia pestis
6016146 365 PTNPTPSEDDIQLILKELQkYLVFPVDREDVLSAWCGIRPLVRdpstvppgtdPTTG--ETQGLVRSHFIFKSD-----T 437 fission yeast 1169945 288 IDNMEVTPEEVDILFREGE-KLAPSLRHTRVLRAYAGVRPLVAs---------DDDP--SGRNVSRGIVLLDHAerdglD 355 Haemophilus influenzae 15603307 288 IDNMVVTPEEVDILFREGE-KLAPSLRHTRVLRAYAGVRPLVAt---------DDDP--SGRNVSRGIVLLDHAerdglE 355 Pasteurella multocida 15899261 286 PDNFTISDEDIAMLVNEGA-YLIPKLKNMRVVRSYASVRPLIKs---------EVS----AREASRDFRIIDHEkenglS 351 Sulfolobus solfatar... 13541671 266 PENFSIDSEDVEAMIEDMS-SLIPLIRNVNYSRTYYSVRPLLEd---------EGDD---ARKASRSFRIIKNg-----E 327 Thermoplasma volcanium 16081722 271 PDSFRPEPEDMQMMIDDMS-ELVPAVKIMPIKRYYYSVRPLIEd---------AGED---ARTASRSFRIVGEEdl--dD 335 Thermoplasma acidop... 15601502 278 IDNLHVTEREVDILLAEGA-KLAPIMANTRVLRAYAGVRPLVAv---------DDDG--SGRNISRGIVLLDHEqrdglK 345 Vibrio cholerae 16554483 267 ADEFATPDAAVERVIDECS-ALLPAASDAPIRTTYWGVRPLYSp---------SDYGd-DARAISRGFYVLDHAdrddtA 335 Halobacterium sp. N... 15790842 281 PEDYPEQQWEVDMVIDELA-ELIPMLDDARTVRSFWGVRPLYEp---------PDVDsdDPTDITRDYFLLAHDdrddlP 350 Halobacterium sp. N... 16123961 279 IDNMVVTAQEVDTLIREGA-KLSPQLAQTRILRAYAGVRPLVAs---------DDDP--SGRNVSRGIVLLDHAsrdgvE 346 Yersinia pestis
6016146 438 GLLTISGGKWTTYREMAEETVNELIKDHDFGkalKPCQTKKLILVGG--EN-YYKNYSARLIHEYHIPLRLAKHLSHNYG 514 fission yeast 1169945 356 GFITITGGKLMTYRLMAEWATDLVCKKLNKT---ARCVTAEQPLPGSteSr-QETNQKVISLPSTIRYSAVYRHGSRATR 431 Haemophilus influenzae 15603307 356 GFVTITGGKLMTYRLMAEWATDLVCKKLNKH---AECVTATQPLPGSseSr-LETNKRVISLPSTIRYSAVYRHGSRATR 431 Pasteurella multocida 15899261 352 GLVSVIGGKFTTGRLAGERVADLVSSKLGIK---SASKTATTKLLSPn-DInLLNYAEKIRLPKVIVRSILDRKGSlde- 426 Sulfolobus solfatar... 13541671 328 GVFTVVGGKFTTGRLIGEHVAKEISKETG----------ATIRIENPdlNStYERFIEKYGRDDKYIAKAMSRIGTide- 396 Thermoplasma volcanium 16081722 336 TLLSVVGGKFTTGRLVGEEIAKRVMHHFG----------TVIDLKDPdlDAtLEAFEKRYASDP-IISRALERRGTide- 403 Thermoplasma acidop... 15601502 346 GFTTITGGKLMTYRLMAEWATDLVAKKLGNT---QSCQTHLRPLPGSqq--aPKALKKTASIAKPVYESAIYRHGERAAN 420 Vibrio cholerae 16554483 336 GLTTVVGGKLTTHRLMAEATADLVADRLGVT---EPSRTANEPLPGHddPErLDALVDTFDAASPADADAR--------- 403 Halobacterium sp. N... 15790842 351 GMTTIVGGKLTTYRMMAEEITDHVCERLGVT---ADCRTADVALPGSadNTaLDDYMTEFGLRSPVAQRSVDRLGSRAGS 427 Halobacterium sp. N... 16123961 347 GFITITGGKLMTYRLMAEWATDKVCEKLGIS---AACTTAQVPLPGSrqSa-EQTLSKVISLPASIRGSAVYRHGDRATQ 422 Yersinia pestis
6016146 515 SraplilelysktdfnklpvtlaDKEVFAPSSDASSDKSVSYasfDEPFTVAELKYSIKYEYTRTPTDFLARRTRLAFLD 594 fission yeast 1169945 432 Llek----------------erlDRSMVCECEAVTAGEVRYAvdeLDVNNLVDLRRRSRVGMGTCQAELCACRAAGLMNR 495 Haemophilus influenzae 15603307 432 Llhs----------------erlDRSLVCECEAVTAGEVRYAvdeLSVNNLVDLRRRTRVGMGTCQAELCACRAAGLMAR 495 Pasteurella multocida 15899261 427 --------------------eryLSSLYILLSLISRGTM----------------------------------------- 445 Sulfolobus solfatar... 13541671 397 --------------------enaMRSVAYAISTIIEGS------------------------------------------ 414 Thermoplasma volcanium 16081722 404 --------------------eyaGIAEAYAISSIIGGKQ----------------------------------------- 422 Thermoplasma acidop... 15601502 421 Flad----------------dakSQAVICECEMVTAGEIEYAikqLDVNNLVDLRRRTRLGMGPCQGELCSYRAASLFSE 484 Vibrio cholerae 16554483 -------------------------------------------------------------------------------- Halobacterium sp. N... 15790842 428 Vldt-----------------ddPNPTICACEAVTRAEIQDAieqSGT-DLNAVRIRTRATMGNCQGGFCAHRLANELHT 489 Halobacterium sp. N... 16123961 423 Llvg----------------nrlDNSLVCECEAVTAGEVRYAvesLSVNNLLDLRRRTRVGMGTCQGELCACRAAGLLSR 486 Yersinia pestis
6016146 595 ARQaLQAVAGVTHVMKEEFGWDDATTDKLAQEARDYIGGMGV 636 fission yeast 1169945 496 FEVaTPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWM 537 Haemophilus influenzae 15603307 496 FGVaTPRQSTTQLASFMEERWRGIEPIAWGEAMREADFTSWV 537 Pasteurella multocida 15899261 ------------------------------------------ Sulfolobus solfataricus 13541671 ------------------------------------------ Thermoplasma volcanium 16081722 ------------------------------------------ Thermoplasma acidophilum 15601502 485 YGQvSGCQSSHLLVDFLEERWKGIKPIFWGDALREAEFSYWI 526 Vibrio cholerae 16554483 ------------------------------------------ Halobacterium sp. NRC-1 15790842 490 AGYdDAT-VRASWDELLAERWRGQRHALWGDQLSQAMLSYAL 530 Halobacterium sp. NRC-1 16123961 487 FKVtTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWV 528 Yersinia pestis
Jiyao W et al.(2023). "The conserved domain database in 2023.",