Conserved Protein Domain Family
Cls

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COG1502: Cls 
Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase [Lipid transport and metabolism]
Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Statistics
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PSSM-Id: 441111
Aligned: 734 rows
Threshold Bit Score: 58.0302
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_042459303   8 SAALD----------------------AAT--------Gp---vE---------ELELLL--TAAE---AYPALERAFLG 40 
WP_102242827  16 VQtq----------------------aKVYeh----tqG-----N---------RLTLLE--DPAA---AVDYKVELIKK 50 
WP_011112130  15 RQPIHpitrlyryagfiewdtgfsqmrKTPppe--vhfG-----S-----------------PGQTpghLRNTLAERIAA 70 
WP_014245358 175 itettplsinfkkhseinpyslnfggyipgnkitffnngpttkerietlveqenylksngehialsndpvFKETKKLIEK 254
WP_085783638   1 -----------mfnkrlffiyflvalhVSLptfasleeGvi-ieN-----------------GSGD---GKKLFLEQVRN 48 
WP_014185654   7 flslvillllsviflsgctlklpelfpEEIpv-----------sNl-------pSESLFI--DKEA---IYSQTVSLINS 63 
WP_059061254  11 lksllkntslssiialllfaiyqlvgdlsplslpteasskiaysqpatlhsssdtlklysnqtqDD---LKALYLSAIQN 87 
WP_011163256 137 AEQLAkyespsq--------pltmdlpGGSpg----frGmrlfiNhphlktingKTRTL---PGDD---LRKVVVDFITG 198
WP_005812052  12 rflplililclfltgcsldikslfvkeEEVpl-----------sNl-------sAEALYF--DGKT---AREKTKELITS 68 
NP_224534      1 -----mnkrqkdklkicviistlilvgifaraprgdtfktflksEe---------aIIYSnqCNED---MRKILCDAIEH 63 
WP_042459303  41 ARH--SISASFRIFDLAtrlrspeacEIGEDWFDLLV-HTLE------RGVSVRLVl--TDFd--------pI----G-- 95 
WP_102242827  51 AKH--HINIITFFWDDT---------SVPKRLAEELN-KANA------RGVEIRVLstfISTig------vdFf---Gqg 103
WP_011112130  71 VPAggTIDWVTYYF-RDl------------cLAKALV-QAHK------RGVRITLT---LEGrp-------rIpy----- 115
WP_014245358 255 AKE--SIVINMDRI-SG---------TIGASFYKALK-EKTTrelkrnPNFKTIIL---TNS----------Iy------ 302
WP_085783638  49 AKD--FLVIGAYKMQKEl--------LPDEELMQALT-EASKk-------IPSKIM---LESrltpeeihkaLdvkeG-- 105
WP_014185654  64 AQT--SIYVEQAVFDDPq-------------LIQMLI-TKSN------SGVDVRVL---LDQ----------Wq------ 102
WP_059061254  88 AKE--SITFSIYSLVNQ-------------EVIHALN-QKVE------AGIPVHIV---CDA----------K----As- 127
WP_011163256 199 AEQ--EIWYNVFDFDlk-------------vIADALKnQHTK------KGVKVTGG---IDA---------------Gti 239
WP_005812052  69 AQK--SIYVEQKIFSDPe-------------LKALII-QKAA------SGIEIRIL---LDQ----------Fet----- 108
NP_224534     64 ADE--EIFLRIYNLSEP-------------KIQQSLT-RQAQ------AKNKVTIY---YQK----------F----Ki- 103
WP_042459303  96 -A-AdlhrlswnarrrliaarevargGRlEv-LSALhsaqagigarlalwpGAhAK-------LRSVLddLNArsesdrr 165
WP_102242827 104 rKeLd--------------------pTT-DavFAYL---------------QL-TP---------GTQf----------- 126
WP_011112130 116 -------------------------aND-Av-IALL------------------SGpdglgdaLRIVTlpGVPspat--- 147
WP_014245358 303 --------------------------------KENL---------------NAeRN-------SSFIIl-NSPt------ 321
WP_085783638 106 -----------------------------Ds-LRAV---------------KK-TG-------AQILS--DLP------- 123
WP_014185654 103 kA------------------------NR-Vt-LDQL---------------KS-QN-------VSVQY--YPAq------ 125
WP_059061254 128 iG-Isr---------------------klPk-ATIV---------------KR-Ls------------------------ 144
WP_011163256 240 n----------------------trpEV-KaiFDDL---------------ATlEGesf--ktVAVKS------------ 267
WP_005812052 109 -------------------------pNK-Tt-LNEF---------------KS-NN-------ISVQY--YPAq------ 130
NP_224534    104 pQ-Ilk---------------------qaSn-VTLV---------------EQ-Pp------------------------ 120
WP_042459303 166 rfLeeapgiaritrerpdgrivavpglpdlTPATHHQKMAVFD----GRQ----LYVGGLDLNE-------RRY---Dsp 227
WP_102242827 127 -----------------------------sLTHSLHEKIFLVD----SEL----AILGGRNISD-------SSL---S-- 157
WP_011112130 148 ----------------------------kswkPQLHEKLYCFSh--pEPV----AFIGSFNPSGngpeddpEIIreiG-- 191
WP_014245358 322 ------------------------------HSPVNHTRAIIID----SNSsspmALIGSKNWSD---------------- 351
WP_085783638 124 ------------------------------EFKNIHLKLLLT-----SEL----ALVGTTNYDNhs----eDFF------ 154
WP_014185654 126 ------------------------------KGQINHTKYLIVD----QKR----ALIYGPAWTE-------EGF------ 154
WP_059061254 145 -----------------------------qG--LMHQKILIVD----QKQ----ILLGSANMTT-------ESLr----- 173
WP_011163256 268 --V-----------------------------GLNHQKIILRDpfgpKAA----VLFLSGNFTQ-------SCIgpeG-- 303
WP_005812052 131 ------------------------------KGQTNEAKFLIVD----LRE----AMVYSFPWTE-------KGF------ 159
NP_224534    121 -----------------------------aGRKLMHQKALSID----KKD----AWLGSANYTN-------LSLr----- 151
WP_042459303 228 Rhcr-apERt------WHDVHAMVRGPVVTA-AAQHLDGFLDIV-A--G--------R-----------R---------- 267
WP_102242827 158 ----------------GKDMEVELRGPVVNQ-VQDHFKRMFDFV-A--GqkiktncaSdettrcedsykRmifsen--dk 215
WP_011112130 192 Dq-----dR-------GYNALIGLKDPVLVEkLAEHARQlh--------------------------------------- 220
WP_014245358 352 -------HQgg----yFHDNDLLVEGPGAAF-IQHTIQEDISNAlSdp-------qnRvss-----tiqSevlnfikikr 407
WP_085783638 155 ----------------IRNFTLILRDPKLLSqIKEVLYN------AehGk-------------------Eit-------- 185
WP_014185654 155 --------R-------SHDLAVELSGRSAWK-AASVFSKDWEFT-Tt---------------------fSl--------- 187
WP_059061254 174 ---------------tHGNLVFNMQHPALAQaLTEKAKSMDEEGnt---------------------------------s 205
WP_011163256 304 DlvnlppEKrnefsipNANHALMIlGTLPAQaTKAELKK------Tleyk--------------------------irgq 351
WP_005812052 160 --------N-------SHNLAVHLSERSAWKlASTVFNRDWIFT-Tt---------------------lSl--------- 193
NP_224534    152 ---------------lDNNLILGMHSSELCDlIITnt------------------------------------------s 174
WP_042459303 268 PPGP---------A----------AP-----------GFLR--TLS---RpArrapfrfsprpLvTE--IERA-HLSRI- 308
WP_102242827 216 yffPv--------Qpvya---dgdEA-----------RILS--HEAvlhQyEkg--------mNrKErlLQQDdILDTV- 262
WP_011112130 221 -qsPpglfyrfttDtnnaihgtdtDIy----------------FWPr------------------TDth----pIVQFLr 261
WP_014245358 408 ESYPiig---------------kqSI-----------RISE--TDS---Sk------------K-LRt-TRNF-IIDMI- 440
WP_085783638 186 --lPsyt----vkDiqn----drtRLs----------------WGPyq--------------------hL-DH-LLQMI- 216
WP_014185654 188 -------------E----------DVe---------------kSSPlpdDnii--------laT-NAn-VRQQ-LIEHI- 217
WP_059061254 206 KLMH---------Cqari---gnqDL-----------ELW---VLP---D-D-------------PD--AVKR-MIQLF- 238
WP_011163256 352 SQYPi--------Sgs-------yKImgekkgpneeaSYIVlsFSPn---------------gGeGD--VNKSiFVPLI- 398
WP_005812052 194 -------------D-----------Ip---------------kTTElveDnis--------vlA-NTn-IKQK-LLDQI- 222
NP_224534    175 Gdfsi----------------kdqTG-----------KYF---VLP---Q-D-------------RKi-AIQA-VLEKI- 204
WP_042459303 309 ---GAAER-LIYLETQFFr-HLPLARAM-A-RRAEAr---pDL-RAI---------------LVLP----AAPedva-fe 357
WP_102242827 263 ---TKIDFkKMRAYNYFMipTERYREFL-E-KNLKE-----GD-SIE---------------IITN----SLE------- 305
WP_011112130 262 ktgSSA---RVRIAASHIr-mESAVDIM-I-SLARR-----GV-DLE---------------ILA-----EST------- 302
WP_014245358 441 ---KKAQT-NIYMEQQYLy-DSYIINSLiKrKL--Ev---pTL-DIR---------------ILAD----HSE------- 483
WP_085783638 217 ---DQAKE-DIAIYQQDIq-DTKIVEAL-E-KKLTS-----GV-KVR---------------ILMS----NYPfg----- 259
WP_014185654 218 ---QASTK-SIWIETTEi-tDPDLKDAL-I-TAAEN-----GY-DVR---------------LILEpsltTKT------- 262
WP_059061254 239 ---QSAKK-TIKVAMFTWt-RADFTQEL-I-AASKR-----GV-RVE---------------AVID----RYS------- 279
WP_011163256 399 ---QNSKG-PIEAVHFAFs-SKQIQSAL-I-ERAARdmsekGQfDFRsvgdtpfamrewsafLLLSg--lKKDlpsgkyl 469
WP_005812052 223 ---QKSTT-NIWIIVSHVt-DSDILQAL-V-DASAK-----GV-DIK---------------LIVDsgimPKS------- 267
NP_224534    205 ---QTAQK-TIQVAMFALt-HSEIIQAL-H-QAKQR-----GI-HVD---------------IIID----RSH------- 245
WP_042459303 358 nSSgldvRYGE-HLQSr---CLS----L----LY----DAfg---------pdRVLVLSpvq--prqLavegraeledap 410
WP_102242827 306 -SA----KFSNnAGYIyslpDAR----Q----LV----LD-------------GIELYQw-------Qrn---------q 339
WP_011112130 303 -------------LRRvtprVEQ----R----LA----NA-------------GIRFRRir-----pSg----------- 328
WP_014245358 484 -SI----ALGGlPNTI----YLR----E----LK----LY-------------GIEVKSrmnvt------------ykqy 517
WP_085783638 260 kER---------PNKSyp-nQLR---------LV----KK-------------GAEVRLtgkkifqdDl----------- 292
WP_014185654 263 --------------PV----TVE----D----LR----SK-------------GVQIRFyp-----sDp----------- 283
WP_059061254 280 -G-------KGtS-AK----VVR----M----LN----EA-------------GIPVRLs------tG------------ 303
WP_011163256 470 tDG----------EAP----ILQalgaAgvtdLQnkirTApaiygerhfrledGTAVKTt-------------------- 515
WP_005812052 268 -------------YQG----DIE----S----LQ----AA-------------GVQIRYyd-----sSah---------p 291
NP_224534    246 -S-------KLt--FK----QLR----Q----LN----IN-------------KDFVSIn------tA------------ 268
WP_042459303 411 I-IYVHSKVSIF--D---G-D-AAILSSA-NLNGRSM---RWDT-EAGLELTAPAHVDLIRRRVmGHWLPrEgdggvdPA 477
WP_102242827 340 KlNYVHEKVLIF--D---E-D-HVIIGSH-NFGTGST---SVSN-EIAVEIKSKRIASRLIDVF-EGEKE-N------SA 399
WP_011112130 329 S-LPMHLKFVLIeeD---N-RaWSIFGSF-NWTKPSF---WLNH-EIAAISSNPVIFESLARCW-DMLKN-Esn------ 390
WP_014245358 518 Q-TMNHRNTISV--D---G-K-ILLTGSN-TISPKAM---QGDSrELSIQIYDSSAIKSFDSNF-LISWN-N------RN 577
WP_085783638 293 P-LHIHAKVLIV--DggtDhQ-LMYLGSA-NFYPPIFdpeERNL-NLGCITCATRYVVPVLNTF-EDDWAfH-------- 357
WP_014185654 284 P---LGMNLVIF--D---N-S-GFILSSS-GWTKYSF---LANH-EFSVTVPSPAASQKLADMF-NQDWE-K------SS 340
WP_059061254 304 Q-GLLHHKFAYI--D---D-A-ILVNGSA-NWTQSAF---KAND-DCFIVLN--SLLPEQKNKK---------------- 352
WP_011163256 516 --SKIHHKVFIFpeD-----S-TAVLGTSfNPSENA----ENNN-EQIVIVKDAAIVEQARGLF-GYLYQ-Qs-----AR 575
WP_005812052 292 P---LEINVGIF--D---R-Q-TFIFSSS-GWGYKAF---VMNH-EVAILVPSPTASQELIVKF-DQDWL-N------SS 348
NP_224534    269 P-CTLHHKFAVI--D---N-K-TLLAGSI-NWSKGRF---SLND-ESLIILE--NLTKQQNQKL-RMIWK-D------LA 325
WP_042459303 478 ALDprtaFEAWRvl-----------aDLNSr---rSPERRegflvhydsdparkLGLP 521
WP_102242827 400 ITK----KADVElldke----idqheRLIEiyr------------------skiLGSV 431
WP_011112130     ----------------------------------------------------------    
WP_014245358 578 QVMdl-dIQNFRa-------------KIKNetlskEISSLin----------avAASF 611
WP_085783638 358 -------EDQ----------------RLVAer-------------------------- 366
WP_014185654 341 VAK----KAQ------------------------------------------------ 346
WP_059061254     ----------------------------------------------------------    
WP_011163256 576 SVTq--eANKrnlkalpspdetvgdeSLERdq-------------------------- 605
WP_005812052 349 PTP----PEQepg--------------------------------------------- 357
NP_224534    326 KHS----EHPTVd-------------DEEKeii-------------------ekSLPV 347
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