Conserved Protein Domain Family
TtcA-like
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cd24138: TtcA-like 
tRNA-cytidine(32) 2-sulfurtransferase and similar proteins
tRNA-cytidine(32) 2-sulfurtransferase, also called two-thiocytidine biosynthesis protein A or tRNA 2-thiocytidine biosynthesis protein TtcA, catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). TtcA belongs to the adenine nucleotide alpha hydrolase superfamily (AANH) that includes N-type ATP PPases and ATP sulfurylases. It forms an alpha/beta/alpha fold which binds to the adenosine group. This domain has a strongly conserved motif SGGKD at the N-terminus.
Links
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Statistics
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PSSM-Id: 467514
Aligned: 26 rows
Threshold Bit Score: 163.984
Created: 4-Apr-2023
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative activePP-loop
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on the structure of Thermus thermophilus sulfur transferase TtuA with bound ATP analog and [4Fe-4S] cluster
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ### ####                      ### # #                              
Q74GW7        22 DFGLIRDGDRIAVAVSGGKDSYTLLHILEGLrrrapvkyELVAVTIDSGYpg-------frSDVIASYLREQgfahhlet 94  Geobacter sulfu...
Q57909        70 KHKIIAPRDIVIVGLSGGKDSLLLLHLLEVYrrk--ygiKLIAVTVDVNIggi------rpWKEDTEGVKLIkhhcemln 141 Methanocaldococ...
NP_219721      7 THAMLQKHTRIAVALSGGKDSLSLLLMLKAIsgrgfpelTIHAIHIGGKYscgaavsgnylSSICDKIQVPLisips--- 83  Chlamydia trach...
AAM01268      68 DYDLFEPREEVVVGFSGGKDSVTCLLMLEPLtrr--lglRIRPVLVETRLhgdpi-wgregREVCEEICRSLgfqleyve 144 Methanopyrus ka...
AAM01361      37 RSGHPRPGSRILVAMSGGKDSFAVAFGLKRLrgg--ygwEVEGAHVAPTVdgkki-sawdvVEEQAKILEIHayllepes 113 Methanopyrus ka...
AAM02267      67 QKAFDEPKGDLAIGFSGGKDSFTCALALEPFlre--wdvNPKLVTVDVRVrgvev--wrpyRKELDRMAKALgyefelvr 142 Methanopyrus ka...
XP_656114     29 REKIISPHDRIIIGFSGGKDSFLLVHVLSTLsknvnfpiDIVAVHVTNPQvgy-----qldLEQSKTICESFgvpfislq 103 Entamoeba histo...
XP_001310516  21 EFKLVEDGDRILIGLSGGKDSLTLTHYLSEWmreknfsfQVVAAHIKFSNl---------pYGIDAKYLEDFcssrkvey 91  Trichomonas vag...
WP_005801071  24 QYGLIEEGDKVLVGLSGGKDSLALVELLGKRshifkprfSVVAVHVVMKNipyqs-dwdylREHAEKNGVPLvvyetsf- 101 Bacteroides
WP_041260116  19 DFNLIEDGDRVLIATSGGKDSSVLLMELAARlgkfgpkcELAAIHIQSDFadk------apREFLQRMAEEYpqvpfyfk 92  Fibrobacter

Feature 1                                      #  #   #                         ###   #          
Q74GW7        95 tdh-------------ydiirekrrpgSSYCSICARLKRGVLYTlaq--------klGCNKLALGHHLDDFVETLLLNQF 153 Geobacter sulfu...
Q57909       142 vphiilkndldvvelseiltkhskgmeFSPCFSCSVIKRHLLGKlakeiaenenipyEKVKLAYGHNLDDNSDTILANIF 221 Methanocaldococ...
NP_219721     84 ----------------------pyeteNPECYTCSRIRRRLLFDtak--------avGATAVAFGHHRDDVVQTTLMNLL 133 Chlamydia trach...
AAM01268     145 pre--------------dvgelaeehgESPCLICSLIRRRELRE-------------RGDKLVLAHTLDDAIVTAMASAI 197 Methanopyrus ka...
AAM01361     114 dv----------------lelkeemnaRKVCYACRTLRRIELGQlae--------ekGFDYIALGHTLDDAAATVILSLL 169 Methanopyrus ka...
AAM02267     143 aee--------------dvaepseelnKPPCKICSAIRRRILAE-------------RHDVVVYGHTAEDAIETLLMSVN 195 Methanopyrus ka...
XP_656114    104 sekm------------sesdiedadknTTFCLNCGKNRRRALLKfak--------ehGFTSIALGHHMDDVAETLLMNQL 163 Entamoeba histo...
XP_001310516  92 hlve-----------dqirdvylenehKETCIHCSRFRRAKLMElar--------kfNCNKLTLGHHLDDIVATLIMNMT 152 Trichomonas vag...
WP_005801071 102 --------------------dpstdtrKSPCFLCSWNRRKALFTvak--------eqGCNKIALGHHMDDILETLLMNIT 153 Bacteroides
WP_041260116  93 dv---------------avearlkegrKLNCYWCSTQRRTELIKfas--------enNFNKIALGHHMDDIVETLLMNML 149 Fibrobacter

Feature 1                                                                        # #    
Q74GW7       154 FVGtlkamapr------------mladngeTTVIRPLVYVEEREIIPFAre----nrFPVVCCSCPVCGTA 208 Geobacter sulfurreducens...
Q57909       222 KGErlkfmrpltrfkynevdyqsfkipleeCIIIRPMLPILERDIIKALeec--gieYYKDKDMCPYSRDR 290 Methanocaldococcus janna...
NP_219721    134 HKAefagmlpi------------vdmvnfgITILRPLIFIPEDLIRKFAke----sgFARITCRCPVISLR 188 Chlamydia trachomatis D/...
AAM01268     198 KGEglnilrpveelgg--mrseyvdydfpeTTIVRPMIRVPEVWTRLIPge----vgLPIFESDCPYSKPY 262 Methanopyrus kandleri AV19
AAM01361     170 TGAerlkllwy------------tgtwrggPRLIRPLVRCPEAVTKALAeel--kvdTVMTEDVCPYAGGL 226 Methanopyrus kandleri AV19
AAM02267     196 RRRdagtfppa------------dlleeddALLLRPLYVVSELRTARVYhevtsrlgLPKVEPECPYAKRY 254 Methanopyrus kandleri AV19
XP_656114    164 FCGcvatipaq------------fttekygIKFIRPLIEVPVVLIQEWTky-----iELPRLIRCKYEKDS 217 Entamoeba histolytica HM...
XP_001310516 153 QHGrfagmavkld--------itvgeekynMTMIRPLAYTPEMDIKQFCae----neFQPAKCRCPWGDTG 211 Trichomonas vaginalis G3
WP_005801071 154 YQGafstmppr------------lvmnkfdMTIIRPMCLVHEADLLELAqi----rgYRKQVKNCPYESQS 208 Bacteroides
WP_041260116 150 YKGefsgmppm------------vpyekypCSIIRPLCYCEESEIIAYAed----adIRKFTCTCEFSKAS 204 Fibrobacter

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