Conserved Protein Domain Family
GmrSD

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COG1479: GmrSD 
DNAse/DNA nickase specific for phosphorothioated or glycosylated phage DNA, GmrSD/DndB/SspE family, contains DUF262 and HNH nuclease domains [Defense mechanisms]
Statistics
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PSSM-Id: 441088
Aligned: 392 rows
Threshold Bit Score: 67.7667
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_014161256   1 MQPSKTTVTGLF--N------SPYQYQIPIFQRGYVWTLDkQVVPLWADIQDRADARLerdqaqqsvgaaalkplQKHFL 72 
WP_041250577   5 IEINKKSVKEFL--Da----gKKHRFVIPEYQRPYAWGEE-EVQTLFDDLVEYTQERId----------------SPYFL 61 
WP_015770233   5 IQVNKQSIKQLL--Es----gKDQTFLIPEYQRPYSWTET-ETKTLFYDLLEFTENEAkrns----------eveGTYFL 67 
WP_014769018   4 FKTDTYTIRQLLk-NetdendRGKNYFIPPYQRKYDWDQE-QVEKLIDDIFEQVNKKTeq-------------gyKPYFI 68 
WP_002273840   5 IEVNKQTVKQLL--Et----gKKKNFVIPEYQRPYAWTAD-QIQTLFDDLVEYTESSEssds----------seeSTYFL 67 
WP_111525990   4 ITAKPEDIRTIF--S--------REYQIPMFQREYSWEQE-QCETLWDDLIDFHNENDk---------------kDKYFL 57 
WP_122122876   5 IEPNLKNIELYLklN------RTENFLIPEYQRGYSWDIG-QCDKLLEDIENFKESESn----------------DPYFF 61 
WP_124785968   4 LNIDQKTIKLLL--Td-----KHSDFLIPDYQRPYAWGED-ECATLWDDLFTFAFPNDdcdaf--------estsDEYFL 67 
WP_069798925   4 LNVDQKTIMLLF--Sd-----KKSDFLIPDYQRPYAWEEG-QCQTLWDDIFSFAFPDNnsdk---------fdsnEEYFL 66 
WP_075574375   5 IEPDLKKIGEYLtlK------KGVSFIIPEYQRAYSWEVK-QCDKFWQDIEDFILAGAe----------------DPYFF 61 
WP_014161256  73 GSLVLTPVTPpf--gRVPAYEVIDGQQRSTTLQLLLLAFRDAARR--VG------Dsq-lP-------KMLDTL-V---R 130
WP_041250577  62 GTIVSYTNDE-------KEQEIIDGQQRITTLCLLLRAIYTKIEK--MDdt--keRkn-fI-------SQIEPAlWe--T 120
WP_015770233  68 GSIVSYENDE-------GEQEIIDGQQRITSLFLLLRAIYTKLLS--YEekt-veQen-fI-------RQIQPAlWk--Q 127
WP_014769018  69 GGVVLSQQSilgderSKKSLEVIDGQQRLTTIVLILASIVQLLKF--QD------RqfenK-------KDVSEH-LindI 132
WP_002273840  68 GTIVAYEKN--------NEQEIIDGQQRITSLFLLLRAIYSKLTS--MSet--pqSkn-fI-------TQIESAlWq--Q 125
WP_111525990  58 GNIVVYPIDE------NEKFSVIDGQQRLTTLLLLIRALFDNAGTv----------------------KALEEClk--tK 107
WP_122122876  62 GSIIIDCSDQ-------NQFSLIDGQQRTTTFLLLLKAILLRLNEvlQTvskdedSea-lIaglkanrNKIMEIlYkaeA 133
WP_124785968  68 GPIVTFKNDA-------GQLEIIDGQQRLTTIMLLLRAFYDKFAN--MKdk---qSik-vR-------DSIAGCvWk--T 125
WP_069798925  67 GSIVTFENDN-------NKKEVIDGQQRLTTLMLLLRAFYAKFGN--MQde---nSks-tR-------ERIAQClWk--T 124
WP_075574375  62 GTIIISCEDK------DNKLNLIDGQQRTTTFILLFKALLICLEEaiEDtktydnPek-lKrtlgmkrDRLLKIlYkaeD 134
WP_014161256 131 NPgpytTD--TD-YH--K-VWPT-----EA---GQD-----EMRFL---Y-GAQQvedicaqyparagQKKVER---PLL 184
WP_041250577 121 DEl---SGe-AD-KS--K-TLLEsrvfeSE---YNG-----ILHNL---L-RTg-------------vADKNAR---DNY 164
WP_015770233 128 AKl---TGe-VD-YT--S-VLITskvidNE---GNK-----ILQDI---L-ETg-------------iADHKAN---DNY 171
WP_014769018 133 SKi---------lKI--KtLNLStmnveEKyilERSdalstDFQKTinfLiE-TKitdkid--lkkiiTNNEDS---EKL 195
WP_002273840 126 DEl---TAk-VD-FE--K-TLIVsrvmgEE---GNE-----IFSNI---L-VTg-------------eVKKEAK---DNY 169
WP_111525990 108 DKl---SSelTN-NI--R-LNSNv---iEN---DKK-----NLEQI---IlQG---------------HCDNKN---SRL 148
WP_122122876 134 ENi---PSmlKDpKKtqNiLILGnk-siNEl--YPE-----EFNKI---I-GASDfedaee--kvfklPYKKNNnryTNY 196
WP_124785968 126 DEf---DDp----DM--NaLKIDsevasDS---DKD-----EFLDI---L-RHg-------------sVGPMAH---SAY 168
WP_069798925 125 NEf---GQp----NL--NiLKIDsevatDN---DKD-----EFLEI---L-KTg-------------iVNKDQK---SNY 167
WP_075574375 135 DEv---YDiiEDfYNhdKeDMLNnl-siNEl--YKD-----ELSII---L-NSKTfaeaek--kvttiKYKQKDnkyTNF 197
WP_014161256 185 VQTFLYFYFACLAYLqgvdvagtgeadehtpsdelvkrirggndvvpldattefdpKRAQALYMALaENVQIMTLQLETE 264
WP_041250577 165 SKNYLLCQNLIDEYAkd-------------------------------------epLTFYHMINNIlNKAIVLPIKADSQ 207
WP_015770233 172 SKNYILFQRLFDKLSel-------------------------------------spTLMLEFIYYTlNRAVVFPIKTDSQ 214
WP_014769018 196 INLVFIIKEKIEIFDd----------------------------------------NELTDFTlQLlNSTWLVVTKTISI 235
WP_002273840 170 SLNYSLFVKLIEDYAsk-------------------------------------epELFYWFIWNVlNRAILLPITADSQ 212
WP_111525990 149 YINYDMFKMKISDWKqgk------------------------------------tsDELNKLILTFlDNVVLLPILCETE 192
WP_122122876 197 FRNFKNFYEKLRENSd----------------------------------------SWLNQFTKTFlKNCQVIEIRSWQV 236
WP_124785968 169 SRNYAFFSKRMAEMAse-------------------------------------wpSYIALFAARIlNNVILLPIEAESQ 211
WP_069798925 168 AKNYRFFQEKIDNFLse-------------------------------------ypSYFAYLPARIlGNCILLPIEAESQ 210
WP_075574375 198 FRNFKYFYNKLKDLSp----------------------------------------EDLNIFADNVlDKTEIIEIRSWNV 237
WP_014161256 265 DDPQVIFETLNARGEPLLASDLIRNFVFLDAARSgkpvsALYAKFWSPFDlalagskgvtsNRYWVekerqgrltypriD 344
WP_041250577 208 DTALTIFSTLNDRGLPLSDADIFKAKIYNNIKEPea--rDIFIQKWQEVS-----------AGAEYade--------siQ 266
WP_015770233 215 DDALSVFSTLNDRGLPLSEADIFKAKMYNRIKKEyk-------------------------------------------- 250
WP_014769018 236 ETGFFIFEKLNDSGIALEPQDLLKNYFFRTSTESe---yNQLTEKWKLFL-----------TTVTNinssk---akilpR 298
WP_002273840 213 NTALTIFSTLNDRGLALSDADIFKANIYNHLNEMdk---qSFVENWKQLD-----------ENAANane--------siQ 270
WP_111525990 193 DDALNIFETINNRGLSLSDADIFKSKLYAGIDSSk--------------------------------------------- 227
WP_122122876 237 EQAITMFNSLNSTGLPLSDADIISAKLYSYVGDKre-------------------------------------------- 272
WP_124785968 212 DTALRIFSTLNDRGLPLADADIFKSQFYKHFSIEgr--kDEFVARWKVLE-----------ETANLifkpt---sgtplD 275
WP_069798925 211 DTALRIFSTLNDRGLPLSDADIFKAQFYKHYSTKnq--kDKFIEQWKELE-----------EITGRifkpl---ngtpmD 274
WP_075574375 238 EQAITMFNSLNSAGMPLLDADIISAQL----------------------------------------------------- 264
WP_014161256 345 LFFYSYtvlrsrettlvghvfeaf---------------ktwwqkepreleqelqrIVSASGHFRELVSPDGTSYLAEFA 409
WP_041250577 267 KLFYYYmfylrakgndrktttpglrkyyssnnflrlydselmddlsailnfwsvvnNKEEIEGENWSCNFEILKVLDILT 346
WP_015770233 251 -------------------------------------------------------kLFIKQWKNLSERAIYAKENVQQLF 275
WP_014769018 299 DFLEQYl------------------------------------------------tIIGDAKDTKTHSSNGKIFKQFKSI 330
WP_002273840 271 KLFYYYmfylrakdndrntt----------------------tprmrkyylqnkekRLYQKELINELSLLASLWTIINNN 328
WP_111525990 228 -------------------------------------------------------rGEFIDEWNDLYDQEDLFRILMYIC 252
WP_122122876 273 -------------------------------------------------------eFNIQWEEILQLTNKLKSKKVVTID 297
WP_124785968 276 ELFTRYmyyrrakkgirdt-------------------------ttkslrdfysdsSYEILREDATLDDLESLLDFWKRV 330
WP_069798925 275 ELFTRYmyfirakqgikss------------------------ttealrkfyekgkYSILKQDDTLSNLKILVDFWHDVY 330
WP_075574375 265 --------------------------------------------------------YSNAVNEKEDFINNWSELKKIVSD 288
WP_014161256 410 RLVKALDVGTITPVYLTLRERLADDSQELRQALSDLASYLTRRSVCNMTTKGYNRFFMRLLQAVAAAQSEPHLALRKVLL 489
WP_041250577 347 SYPNEFWKYPVITYYLRYKDSDSFEDKFLLFLRKLFVNLCSRYIVTPTVNAVKQNILNLNSEIINSDEPKFEFKAVDQNI 426
WP_015770233 276 YYYMFYLRALEKDTATTTLGLRRFYSKGGFNRLYKSNLLKHLDKILDLWVVMNRRETIDNKPWTENIDIIKILDTLSSYP 355
WP_014769018 331 QQSDFTKSIELLEHLIKIATEYGKLKRNDSIAQYLNVMNFKLGYLIVLSFYKRFDDEYLNYKNDILLIVVKLGLVYLVTG 410
WP_002273840 329 TIIDDEAWSENSEILKVLDALSSYPNEFWKYPVVIYYLRYKDSVEFESNFLTFLRRLFAVLSARYIVTPTINAVKRSILN 408
WP_111525990 253 RAQENDISREKGLRSYFSSKTGRLQNTGNVMASLKKLNAIIDTKVGIYNDSLWNILESYPNQYWRYPLYVFLHKYLIWKE 332
WP_122122876 298 SVLQQFMYINRAKEQGYLKSYIYVRTPGLRRYYADHEQDLLKNPFLLCNNLKKIAYKWDKIKDYSIIKLLLKCNVNIKLY 377
WP_124785968 331 DAQEGFSERVARRLFVLNYAPNGMWAYLLSTWFLAKRNTKGELDDKELYDFLCYITGFIYAYSLERPGVNALRGPVYPAL 410
WP_069798925 331 NQNQERFSTKILRKLFILNSAPNGMWTYFLSVYFLQNKNENNQLEENKLDEFLNKTIAFVWAFAFTNPGVNALRTPIYAE 410
WP_075574375 289 LEKSNVVNIDGILKQYMYIKRAIDKEYISEGQSVDVSTPGIRRYYTDLNKKLLEDPLRLTSRFLKIAKIWDRIKDYSIVQ 368
WP_014161256 490 EATADSELWPSDGAFQEQWLHRPVYFAMKPARVCGILRALEYAARGTMQGSNHVPVQSALTVEHVMPQSWAVVPSYQVGG 569
WP_041250577 427 ITEELKNPHRNVVRMLLKLLAYDEDSQDELLPEKWEIEHILPRKWQDSYFPNSSEEEVNEIIEHLGNKIPFEKRLNIVAS 506
WP_015770233 356 NESWKYPVVVFYLSHGENEEFESYFLKFLRKLFLELTANYLVNPTVSAVKADILKLNVEIIDTMSPKVAFKNIPITVLQE 435
WP_014769018 411 QSKELSVVIPNLCYEIINKGKDIQDTLVIANSYINGLISKKKDTFDEVVSSTNLWRKKPLTRLLLSILEFHVGGNKLPNY 490
WP_002273840 409 LNAEVYRSENPKFDFKPIDEEELKEKIKHSHRNTVRMILKVLAYQKQEDLLPPKWEIEHILPQKWQSSYFPDSTEQEVKL 488
WP_111525990 333 DGELFLPEEYYEEYKKLVMLTTAYYFIKGVVYNSVNTVKDTTFKVCAKIENNDNYLSEYIENMRNDLKIFYNKLESADLG 412
WP_122122876 378 LAAYLYRFELDEITEDKIINVCESLLKLFSLLELGDAGYSSNKFKIFLYAEIIKMVDFNIPEHVICQDFYDHIHDKWNVK 457
WP_124785968 411 IDIVEGRKVDFSAHLFDRETITGRFRSYQFTNQRRFTRSMLVWWAYSDPKQPLMDLDTTLEIEHIYARKRNEVHPLSNRS 490
WP_069798925 411 MVNIVTDKTVNFDEHKFDEHTLRTAMNNFEFKNGRPITRSMLTWWAFKDDQQEIPFLNTNFDIEHIFARKRQENDKSLSN 490
WP_075574375 369 LAFKFNENIKVYLISYLYRFEVDEISEKLVSDFMNYLLKIFVVLELVDTGFSSARFKSFLFGLNTKLVDENIDPQNIQYE 448
WP_014161256 570 MTDAQRVVRDMAVHGFGNLTLLTQPLNSSVSNGPFNDWQDASGQTVEGKRSKLGQSALLMNTYFGQKD 637
WP_041250577 507 NGYFEKKKALYKKSKIVMVQEFSQIHSNDWKLDQIRERDIRVSDRIMEIFDSWTLDINNENETKLTEE 574
WP_015770233 436 RVKTPNKNLVRMILKMVIYDNQDELLPEKWEVEYILPQKWSNRFTESVENKQAKTYINYIGNKIPFEK 503
WP_014769018 491 FNLFQIMPQEYSSEFQYDEIDEDNCNKYANYIGNILIDKDSKYADIDDNNFKERYKNDSDVILNNLDK 558
WP_002273840 489 LIEHIGNKLPFEKKLNIIAGNGYFQKKQDSYNKSKITIVQELSQEKSKWELDDIRERDIRISDELLDL 556
WP_111525990 413 RCKRGIILLSGFLNKSQSVEDFYDLILNSNIEIEHILPRKWSDNNDWDEQKANEVMETLGNLAPFEKK 480
WP_122122876 458 EVEDAILTYDKNMLVFVNEYLYAKNKNLKFNFSETVNVEHIMPASGRNIETIRHDAKMDKNEFENVIN 525
WP_124785968 491 NLEALGNKAMLEKRVNIRASDYQLTDKRKYYEGYVNDKGVEVSGTAVRELVEIARCGDFAESDIEMRT 558
WP_069798925 491 TKLLEALGNKSLLEDKINIRASDYRFSDKIKYYKGFTTDKGQHKAGSIISELVNIADNKTDFTEQDII 558
WP_075574375 449 IKTHIEKNWNKADLKERVLDYTKNPLVYLDEYIYCKKEGSKFILPEKYEIEHIMPRSGRNIEQIREDA 516
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