2AYI


Conserved Protein Domain Family
Peptidase_M29

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pfam02073: Peptidase_M29 
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Thermophilic metalloprotease (M29)
Statistics
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PSSM-Id: 426588
Aligned: 200 rows
Threshold Bit Score: 317.505
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AYI_D            4 FKRNLEKLAELAIRVGLNLEKGQEVIATAPIEAVDFVRLLAEKAYREGASLFTViYGDQELARKRLALAP-EEGLDKAPA 82  Thermus ther...
jgi:Hprae_0903    2 SDIKLNKYAKLLVDYSLELKKGDQVLIQAEDVSQALVKEVYQEVLKKGGHPLVI-TKFAEQEELFYKYAS-EEQLKYKSP 79 
WP_013405890      2 SDQKLVKYADVLLNYSLELKKGDEILIQGENVSNELIKEVYKNALKIGAHPFII-TTIPEQEELFYKFAG-ESQLNYTSP 79  Halanaerobiu...
jgi:Haur_3114     2 ADPRVLKMAHTLVNYSMKIKEGELVVLQSEPAAAPLVQAMYREILLAGGHPVAH-TVMPGLSRILLNHGN-DKQLQWISP 79 
WP_013561311      2 ADANVTRMAQVLVDYSTAIQPGDTVLIEATTLAEELVREVYRRVLERGGHPHLL-LSLPDQEEIFYTAASrDEQLDFIPA 80  Anaerolinea ...
WP_013217765      2 TDPRINKLAELLVRYSTRIQPGDKAVINTPQAALPLARAIYREVLAAGGHPIV--MPRGDYDDLLFRHGT-EVQLEFIHE 78  Dehalogenimo...
Q3Z813            2 VDPRTEKLADLLVNYSIEVKPGDTVAVNYFSGALPLAVEVYKKILAAGGHPLMQ-VSKNEFLEYLLKYGS-DEQISYVHF 79  Dehalococcoi...
jgi:Tmar_0246     2 TDPRVRKLAQVLVRYSLGLEAGDHFLIQTTDLATPLVQAIYREALQVGAFPQVL-AQLEGLSEIYLKEAS-EEQLRVLTP 79 
jgi:RoseRS_2644   2 ADPRVEKMAQVLVHYSLAIKPGDLFRIIAPPAAAPLVRALYREALLAGAHPYLA-LTLEETEELLFRYGS-EAQIRFVSP 79 
jgi:Haur_2642     2 FDQRWQQLAKIIVHHSLELQPNDLLRIQAEAIAKPLLYALYREALHAGALVIPK-IVDPVFEEIMLKEGT-PEQLQFVPS 79 
2AYI_D           83 WLyegmARAFREGAARLAVSGS-DPKALEGLPPEKVGRAQKANARAYKPALEAITEFVTNWTIVPFAHPGWARavfpglP 161 Thermus ther...
jgi:Hprae_0903   80 FI----KHLMKNVDASLKILGNnNTKNLAGVNPEKIKMKAIAQKEISEIVMNRAAEGSLNWNLCQFPTQADAQ------E 149
WP_013405890     80 YL----KYLLENVDATLKILGHnNTKNLASVDPEKIKKRTLAKREITEIMLKRAAEGSLNWNVCQYPTQADAQ------E 149 Halanaerobiu...
jgi:Haur_3114    80 YD----RLGIETADVRIRIDAQsNTRELSQVDPERQSVFQKSRRELMGTLMSRTHAGDFRWCVTLFPTEGLAQ------D 149
WP_013561311     81 LH----HYAAENFDARIRIYSEgNTRGLNSVNPARQARRQKALSVVQRAVFRRAAEDQLRWVSTLFPTQAYAM------E 150 Anaerolinea ...
WP_013217765     79 PQ----RHITEHYDARFAILAEdNTKKLSTVDPSRMVVFDRARTELMKTMMRRSAEGAFKWVVAPFPTNAMAQ------D 148 Dehalogenimo...
Q3Z813           80 PQ----RYITEHYDATIHLLAEeNTKSMTSIDPRKMVAFEKARTDLMETSMRRTAEGNFRWVLAIYPTNGYAQ------D 149 Dehalococcoi...
jgi:Tmar_0246    80 LD----RVAFEQYQHAMVIHAPhNVKALSGVDPRRLAIVHEARRQLADRLMARIGQGG-KYCVTLFPTQALAQ------E 148
jgi:RoseRS_2644  80 LM----RQEIEEINATIRIMASdNTRALSGIDPNKIALRRQALSDIQKRTMQRSAEGTLNWCVTLFPTNAAAQ------D 149
jgi:Haur_2642    80 TL----VHEIETMTTWCDIYSEiNTKHFNQADQQRQLLRRKAFGPVQVLFDSRAAQNQLRWCDVLYPTEAFAQ------D 149
2AYI_D          162 EEEAVRRLWEAIFQATRAdQE--DPIAAWEAHNRALHEKVAYLNArrFHALHFK-GpGTDLVVGLaEGHLWQGGATATkg 238 Thermus ther...
jgi:Hprae_0903  150 AGMSLIDYRDFVYKACHLdKE--DPIAYWKKFGKELERIASVLNQ--KNELHFIaE-DTDLKCKV-GGRTWVADKGEE-- 221
WP_013405890    150 AGMSLLDYREFVYQSCHLnRQ--DPVAYWTQFGQELERIAKILEE--KSELHFLaE-NTDLKLKV-KGRKWIADKGKE-- 221 Halanaerobiu...
jgi:Haur_3114   150 ANMSLPDFEDFVYGVCFLnEA--DPIAKWQELHDMQAHLINYLQN--KREVHILgE-GTDIRVGI-AGRSFVNCAGDA-- 221
WP_013561311    151 AGMGWHEYRNFVFSACAVdGSvpDPVAYWQEVGRQQQKFISAFQG--HDRVTLRgT-NVDLTLSI-RERRFLNSCGIH-- 224 Anaerolinea ...
WP_013217765    149 AEMSLEEYEDFVYGACLPdMA--DPIGYWNGQSRKLQKVIDWLAG--RREVRITaP-ETDLTLSI-EGRSFVKCDGRF-- 220 Dehalogenimo...
Q3Z813          150 AGMSLEEYTDFVYNACLPdMN--DPVGFWKNLNTRQQKVVDWLKG--KKQVHIKaK-ETDLRLSI-EGRTFVSCDGKL-- 221 Dehalococcoi...
jgi:Tmar_0246   149 AGMSLSDYQEFVFEACRLnDD--DPVAAWQEVSHRQQRLVEFLNG--VKEMRVVgD-GTDLTVSV-AGRTWINADGHI-- 220
jgi:RoseRS_2644 150 ADMSLSDFEDFVYRACKLhYD--DPVAEWRKTAAEQQRIADLLNE--CSVIRLVaP-DTDLTYRV-AGRTWINCAGDR-- 221
jgi:Haur_2642   150 AGMSLWDFEDLVVKSYLLdHP--DPVTAWQTIHQQQQKVTHFLNS--CRSIRIEgP-DVDLSYRC-EDRIWINCAGKR-- 221
2AYI_D          239 grlcnpNLPTEEVFTAPHRERVEGVVRASRPLALGGTLVEGIFARFERGFAVEVRAEKGEEVLRRLLDTDEGARRLGEVA 318 Thermus ther...
jgi:Hprae_0903  222 ------NYPGGEVFTGPIENSVEGKIRFSFPGIYSGQEIKDIRLEFKAGKVVQASAAKGEKLLNSLLETDEGARYVGEVA 295
WP_013405890    222 ------NYPGGEVFTGPIEDSVEGKIRFSFPGIYSGKEIEDIRLEFEAGRVVDASAAKGEELLHSLLDTDEGSRYVGEIA 295 Halanaerobiu...
jgi:Haur_3114   222 ------NFPDGEFFTGPEETNVNGVVRFSFPAIYNGREVEDVQLTFEAGKVVKATAKSGQDFLEQMLNVDAGARILGEFA 295
WP_013561311    225 ------NMPDGEIYTGPVEDSVEGWVRFTYPAIYGGRAVEGVELTFEKGQVVKASARTNTEFLEQTLNSDPGARYLGEFA 298 Anaerolinea ...
WP_013217765    221 ------NMPDGEIFTGPVENSANGHVYFSYPAIEAGREVTGVRLWFENGNVVKATAEKNEEFLLRTLDTDEGARRLGEFA 294 Dehalogenimo...
Q3Z813          222 ------NMPDGEIFTGPVEDSAEGYVYFSYPAIEAGREVTGIRLWFEKGKVVKATAETNEEFLLKTLDTDPGARYLGEFA 295 Dehalococcoi...
jgi:Tmar_0246   221 ------NFPDGEVFTGPVEDSVRGTIRFSFPGIFQGQEIEDIRLRFEDGRVVQAEAARGQALLDALLATDQGARYVGEFA 294
jgi:RoseRS_2644 222 ------NFPDGEVFSSCDETATQGYIRYSFPAIYAGREVEDIRLWFENGRVVKATAAKGEDLLHSLLNMDEGARRLGEVA 295
jgi:Haur_2642   222 ------NLPDGEVFTAPIEDSVNGRLKISYPSIYQGNLVSGIQLVIEDGKVTQATAEQGQDFLHTMLDLDAGARYIGEVA 295
2AYI_D          319 LVPADnPIAKtglVFFDTLFDEN--AASHIAFGQAYQENlegrpsgeafrkRGGNESLVHVDwMIGSEEMdvdglyeDGT 396 Thermus ther...
jgi:Hprae_0903  296 VGCNK-GINK---FSRNMLFDEKigGTIHLALGRSYPET------------GGENISTIHWD-MLCDMKN-------GGE 351
WP_013405890    296 VGCNQ-GIDR---FTRNMLFDEKigGTIHLALGRSYPET------------GGENISTIHWD-MLCDTKN-------GGE 351 Halanaerobiu...
jgi:Haur_3114   296 FGTNP-NIKN---YTRNILFDEKmgGTIHMAVGASYPET------------GGLNQSAIHWD-MVCDLRQ-------NSE 351
WP_013561311    299 IGTNF-HINR---FTGNILFDEKigGTFHLALGNSYPET------------GGRNQSTIHWD-MICDLRT-------DSE 354 Anaerolinea ...
WP_013217765    295 IGTNE-GITR---FTGEILFDEKigGSFHLALGAGYPET------------GSVNESAIHWD-MVCDLRN-------GGQ 350 Dehalogenimo...
Q3Z813          296 IGTSE-GIQK---FTKQILFDEKigGSFHLACGAGYPET------------GSVNKSAVHWD-MVCDLRD-------GGE 351 Dehalococcoi...
jgi:Tmar_0246   295 IGTNE-RITR---FSRNLLFDEKigGTVHLALGASYPIT------------GGRNQSAIHWD-MICDLRQ-------GGE 350
jgi:RoseRS_2644 296 FGTNY-DITR---FSRNILFDEKigGTVHLALGAGYPET------------GSQNVSALHWD-MICDMRQ--------GE 350
jgi:Haur_2642   296 FGLNP-GITK---PTGHTIFDEKmaGTMHLALGRAYPEC------------GGKNESTLHWD-LVCDLHQ--------AE 350
2AYI_D          397 ----RTPLMRRGRW 406 Thermus thermophilus
jgi:Hprae_0903  352 iyadGELIYQAGEF 365
WP_013405890    352 iyadDELIYHDGNF 365 Halanaerobium hydrogeniformans
jgi:Haur_3114   352 vyvdGQLFQKNGTF 365
WP_013561311    355 ilvdGEVVYRNGTF 368 Anaerolinea thermophila
WP_013217765    351 itvdGELLYRDGNF 364 Dehalogenimonas lykanthroporepellens
Q3Z813          352 iwvdGELLYKNGEF 365 Dehalococcoides mccartyi 195
jgi:Tmar_0246   351 iyadGELIYRDGKF 364
jgi:RoseRS_2644 351 ayadGRLIYKDGKF 364
jgi:Haur_2642   351 vyanNALCYKNGEF 364
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