12AS_A 1 MKTAYIAK-QRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAEKAVQVKVKALPDAQFEVVHSLAKWKRQ 79 Escherichia coli 21263425 1 MKTAYIAK-QRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQ 79 Escherichia coli O1... 21263425 1 MKTAYIAK-QRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQ 79 Escherichia coli O1... 21263422 4 ISSLDILEtEIAIKKVKDFFESHLSKELDLLRVSAPLFVIPESGLNDNLNGTERPVSFDTKSGER--VEIVHSLAKWKRM 81 Fusobacterium nucle... 1168531 1 MKKTFILQ-QQEISFVKNTFTQNLIEQLGIIEVQGPILSQVGNGMQDNLSGIEKAVQVNVKCIPNAVFEVVHSLAKWKRH 79 Haemophilus influenzae 21263438 1 MKKSFILQ-QQEISFAKNTFTEKLAEHLGIVEVQGPILSQVGNGIQDNLSGAEKAVQVNVKQITDATFEVVHSLAKWKRH 79 Pasteurella multocida 21263435 1 MKKSFIHQ-QEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGMQDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRH 79 Streptococcus pneum... 21263436 1 MKKSFIHQ-QEEISFVKNTFTQYLIAKLDVVEVQGPILSRVGDGMQDNLSGTENPVSVNVLKIPNATFEVVHSLAKWKRH 79 Streptococcus pyogenes 21263431 1 MKTAYIAK-QRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQ 79 Salmonella typhimurium 21263421 1 MEKSFILQ-QQGISFAKHTFTQKLMEHLGLIEVQGPLLSQVGDGIQDGLSGREKAVSVSVKQIPGTAFEVVHSLAKWKRH 79 Treponema pallidum 21263439 4 LQKAKINQtQKAIVEIKNSFQKHFAKNLNLSRVTAPLFVEGQSGLNDHLDHKQKAVSFYAKKLDKT-LEIVQSLAKWKRL 82 Ureaplasma parvum 21263430 1 MKKQFIQK-QQQISFVKSFFSRQLEQQLGLIEVQAPILSRVGDGTQDNLSGSEKAVQVKVKSLPDSTFEVVHSLAKWKRK 79 Yersinia pestis
12AS_A 80 TLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFG-LA 158 Escherichia coli 21263425 80 TLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFG-LA 158 Escherichia coli O1... 21263425 80 TLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFG-LA 158 Escherichia coli O1... 21263422 82 ALYRYNIENDKGIYTDMNAIRRDED-TDFIHSYYVDQWDWEKIISKEDRNEEYLKDVVRKIYSVFKKTEEYITTEYPkLT 160 Fusobacterium nucle... 1168531 80 TLARFNFKEDEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPEGRRNFAYLKETVNSIYRAIRLTELAVEARFD-IP 158 Haemophilus influenzae 21263438 80 TLARFNFAQGEGLFVHMTALRPDEDSLDQTHSVYVDQWDWEKVISAEQRNLAYLKETVRAIYAAILETEEAVSKKFG-LA 158 Pasteurella multocida 21263435 80 TLARFGFGEGEGLFVHMKALRPDEDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYD-IE 158 Streptococcus pneum... 21263436 80 TLARFGFNEGEGLVVNMKALRPDEDSLDQTHSVYVDQWDWEKVIPDGKRNLAYLKETVETIYKVIRLTELAVEARYD-IE 158 Streptococcus pyogenes 21263431 80 TLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAEVHKQFG-LA 158 Salmonella typhimurium 21263421 80 TLARYGFQDNEGLFVHMIALRPDEDFLDQVRSVCVDQWDWEKVVPVGSRNLAYLKDTVRKVYGALRESEVLVSERFG-LR 158 Treponema pallidum 21263439 83 ALLDYGFSLYEGLYTDMNAIRADDD-IDEIHSIYVDQWDWEILINNQDCNLDFLKSIVNKIYSTIRIVQLEIDQLYNpKQ 161 Ureaplasma parvum 21263430 80 TLGRFDFGADQGVYTHMKALRPDEDRLSAIHSVYVDQWDWERVMGDGERNLAYLKSTVNKIYAAIKETEAAISAEFG-VK 158 Yersinia pestis
12AS_A 159 PFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILV 238 Escherichia coli 21263425 159 PFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILV 238 Escherichia coli O1... 21263425 159 PFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILV 238 Escherichia coli O1... 21263422 161 KKLPEEITFITAQELENKYPNLTPKNREHAAAKEYGAIFLMKIGGKLSSGEKHDGRAPDYDDWD---------LNGDIIF 231 Fusobacterium nucle... 1168531 159 SILPKQITFVHSEDLVKRYPDLSSKERENAICKEYGAVFLIGIGGKLSDGKPHDGRAPDYDDWTTESENGYKGLNGDILV 238 Haemophilus influenzae 21263438 159 TFLPKDIQFVHSEELVQRFPNMNDKERENAICKEYGAVFLIGIGGKLSDGKPHDVRAPDYDDWTTPSEGEYKGLNGDILV 238 Pasteurella multocida 21263435 159 SILPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDYDDWTSESENGYKGLNGDILV 238 Streptococcus pneum... 21263436 159 AVLPKKITFIHTEELVAKYPDLTPKERENAITKEFGAVFLIGIGGVLPDGKPHDGRAPDYDDWTTETENGYHGLNGDILV 238 Streptococcus pyogenes 21263431 159 PFLPEQIQFVHSQELLARFPDLDAKGRERAIAKELGAVFLVGIGGKLSDGHRHDVRAPDYDDWSSASELGYAGLNGDILV 238 Salmonella typhimurium 21263421 159 AFLPADIVFVQSEELVRRYPHLDSKGREDAICKEHGAVFLIGIGGVLSDGKPHDVRAPDYDDWTTPSEGEYKGLNGDILV 238 Treponema pallidum 21263439 162 IILPDSITFISSQELEDLYPHLSPSRREYEFAKIHKAIFIYQIGYPLKSGYIQSIRSPEYDNWN---------LNGDLIV 232 Ureaplasma parvum 21263430 159 PFLPDHIQFIHSESLRARFPDLDAKGRERAIAKELGAVFLIGIGGKLADGQSHDVRAPDYDDWTSPSAEGFSGLNGDIIV 238 Yersinia pestis
12AS_A 239 WNPVLEDAFELSSMGIRVDADTLKHQLALTGDE-DRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQAGV 317 Escherichia coli 21263425 239 WNPVLEDAFELSSMGIRVDADTLKHQLALTGDE-DRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGV 317 Escherichia coli O1... 21263425 239 WNPVLEDAFELSSMGIRVDADTLKHQLALTGDE-DRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGV 317 Escherichia coli O1... 21263422 232 NYPLLGIGLELSSMGIRVDEKSLDEQLKIANCE-DRRSLPYHQMILNKVLPYTIGGGIGQSRICMFFLDKLHIGEVQASI 310 Fusobacterium nucle... 1168531 239 WNDQLGKAFELSSMGIRVDESALRLQVGLTGDE-DHLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVQSSV 317 Haemophilus influenzae 21263438 239 WNPILERAFELSSMGIRVDETALRKQLALTNNE-DRLKFDWHQDLVNGRLPLSIGGGIGRSRLVMLLLQKKHIGEVQSSV 317 Pasteurella multocida 21263435 239 WNESLGGAFELSSMGIRVDEETLRRQVEITGDE-DRLELEWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSV 317 Streptococcus pneum... 21263436 239 WNDQLGSAFELSSMGIRVDEEALKRQVEMTGDQ-DRLGFDWHKSLLNGLFPLTIGGGIGQSRMVMFLLRKQHIGEVQTSV 317 Streptococcus pyogenes 21263431 239 WNPVLEDAFELSSMGIRVDADTLMRQLALTGDE-DRLQLEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGV 317 Salmonella typhimurium 21263421 239 WNPVLGRAFEVSSMGIRVDEGALRTQLALTGDE-DSLACSWHQDLINGRLPQSIGGGIGQSRLAMLLLQRKHIGEVQASV 317 Treponema pallidum 21263439 233 YHKLNDQAIELSSMGIRVSKQDFIKQTNFANLKnDQENNFYHQMILNNQLPQTIGGGIGQSRLCMFLLNKKHIGEVQVSV 312 Ureaplasma parvum 21263430 239 WNPILEDAFEISSMGIRVDAEALKRQLALTGDE-DRLELEWHQSLLRGEMPQTIGGGIGQSRLVMLLLQKQHIGQVQCGV 317 Yersinia pestis
12AS_A 318 WPAAVRESVPS----LL 330 Escherichia coli 21263425 318 WPAAVRESVPS----LL 330 Escherichia coli O157:H7 21263425 318 WPAAVRESVPS----LL 330 Escherichia coli O157:H7 21263422 311 WSQEVHEICRQmnikLL 327 Fusobacterium nucleatum subsp. nucleatum 1168531 318 WPKEMLEEFSN----IL 330 Haemophilus influenzae 21263438 318 WPKWVMEQFDN----IL 330 Pasteurella multocida 21263435 318 WPQEVRDTYEN----IL 330 Streptococcus pneumoniae 21263436 318 WPQEVRDSYDN----IL 330 Streptococcus pyogenes 21263431 318 WPAQVRESIPA----IL 330 Salmonella typhimurium 21263421 318 WPRSVREEFEN----IL 330 Treponema pallidum 21263439 313 WPNEYKDELLKkgikLL 329 Ureaplasma parvum 21263430 318 WGPEISEKVDG----LL 330 Yersinia pestis
Jiyao W et al.(2023). "The conserved domain database in 2023.",