Conserved Protein Domain Family
Stp1_PP2C_phos

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NF033484: Stp1_PP2C_phos 
Stp1/IreP family PP2C-type Ser/Thr phosphatase
Many Gram-positive bacteria have a protein kinase/protein phosphatase gene pair that responds to peptidoglycan metabolites and can be instrumental in resistance to beta-lactam antibiotics. Characterized examples of the phosphatase component are Stp1 of Staphylococcus aureus and IreP of Enterococcus faecalis.
Statistics
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PSSM-Id: 468046
Aligned: 189 rows
Threshold Bit Score: -1
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_004799854      8 KTHIGYKRALNQDTF-LLEERDGVLLAIVCDGIGGGNGGEVASQMACAHVKDRF-KSMPkclqDVDVKRWLETTIREAND 85  Amedibacillu...
WP_010530490      6 QTDQGRVRPHNEDDGgVFYNRTGQMLAIIADGMGGHQAGDVASKMATSFVRDKW-QQTDdfnsSEASETWLKETLEEANL 84  Lentibacillu...
WP_010096722      6 LTDRGQVRSHNEDSGgIFSNGNGQYLAIIADGMGGHQAGDVASEMATSIIEEKW-RKIEkllsPEETEEWLKNALLEMNT 84  Ornithinibac...
WP_011065909      6 LTDRGKVRNHNEDAGgLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKW-LETDhlggPEQVEGWLKEAVQQTNQ 84  Oceanobacill...
WP_003181675      6 KTDRGKIRQHNEDDAgIFTEKNGLVLAVVCDGMGGHLAGDVASRMAVSALRDIWeETEEvpasPAESEAWLKEQISAVNQ 85  Bacillus
WP_013352219      6 KTDTGKVRQHNEDAAgIFTKE-EAVLAVVADGMGGHLAGDVASRMAVAAMEEQWnQAETvpslPSDCEVWLKDRIHEANA 84  Bacillus amy...
3_ncbifamImport   1 KTDTGKIRQHNEDDAgIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWnEAETiptaPSECEKWLIEQILSVNS 80 
WP_011247159      8 LTDVGKVRSHNEDNGgIFVSA-AGTLAIVADGMGGHSAGDVASRLATEVMEAEW-RKLKeplsASSAEQFLKEAFEHANA 85  Alkalihaloba...
WP_012810687      6 KSHIGLVRTMNQDGYaVVDDLPVGVLFVVADGMGGPQAGDVASRIAVERVSEYV-GRHLs--aEANPREVVSSAIADANE 82  Alicyclobaci...
WP_015891991      6 KSHVGRVRQVNEDYYaCVTDLNGRVLAIVADGMGGHQAGDIASRLAVERIVKEL-RHLDgdleAEDVREQLMNAVLLANK 84  Brevibacillus
WP_004799854     86 LIFMQSAKKRSLKGMGTTLVGVLVCEQGTYIFNVGDSRTYGLYAKDFLCLTEDHSYIAALLKNGQITMEEAAKHPNRNVL 165 Amedibacillu...
WP_010530490     85 ALLEHAQNNEACAGMGTTVVGVICTDEFIAVAHVGDSRCYKLSGEGFVQITEDHSLVNELVRSGQISEEDAEHHPRKNVL 164 Lentibacillu...
WP_010096722     85 SIYQHSLEKEECQGMGTTIVVAVCTEEFISVAHIGDSRCYLYNDFSFKQITEDHSLVNALVQSGQISKEDALQHPRKNVV 164 Ornithinibac...
WP_011065909     85 HIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGDSRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPRKNVI 164 Oceanobacill...
WP_003181675     86 KLFDHSRAHEECQGMGTTVVCALYTGKTLTVAHIGDSRCYLLQGGSFIQLTEDHSLVNELVRTGGISKEDAEHHPRKNVL 165 Bacillus
WP_013352219     85 KVYDHAKANEECRGMGTTVVCALFTGKFVTVAHIGDSRCYLLQDGEFTQLTEDHSLVNELVKTGEISKEDAEHHPRKNVL 164 Bacillus amy...
3_ncbifamImport  81 KIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHPRKNVL 160
WP_011247159     86 SILAHAKENPDCEGMGTTAIAAVCTEEYTTLAHVGDSRAYIYNGKQLVQQTDDHSLVAELVRSGQISAEEADHHPRKNIV 165 Alkalihaloba...
WP_012810687     83 EIYRQAAAVPEYAGMGTTIVCALALADRMVVAHVGDSRAYALTGDEFRQVTEDHSLVAELVRRGHLSASEARHHPQRNIV 162 Alicyclobaci...
WP_015891991     85 EVYEYALEHPECSGMGTTVVAALFDQSSVITAHIGDSRLYFYNQDGLVMKTEDHSLVNELMKSGQITAEEASVHPHRNVI 164 Brevibacillus
WP_004799854    166 TNALGIWDQVRIDIHKIKNDY-QALLICSDGLHGYVHEDVLREIL-AQ-----SISAEEKVNLLIQKALDAGGFDNIS-A 237 Amedibacillu...
WP_010530490    165 LKALGTETDIAADTQSMKWEReNKLLLCSDGLTNKVTDEELSSFI-KK-----DPDLGAVSNDMVELANNRGGEDNIS-L 237 Lentibacillu...
WP_010096722    165 LRALGTSETVEPDIQTINWEDgDKLLLCSDGLTDKVRDHELAEYL-KS-----TNDIEGVGKLLVDLANERGGEDNVS-L 237 Ornithinibac...
WP_011065909    165 LRALGTDNQVNVDLKTLTWQKnDRLLLCSDGLSDKVTEHELADFT-DS-----TKDIEVIGNELIQLANNRGGEDNIS-L 237 Oceanobacill...
WP_003181675    166 TKALGTDPEVKVEAHTFEIEPgDQVLLCSDGLTNKVDDETLKDML-TT-----LSSAEEKADQLVQLANDNGGEDNIT-V 238 Bacillus
WP_013352219    165 TRALGTDETISPDARSFELSDgDQLLLCSDGLSNKIEDHEIKQML-QA-----ESAPQEKVDLLISKANQNGGEDNIT-A 237 Bacillus amy...
3_ncbifamImport 161 TKALGTDQLVSIDTRSFDIEPgDKLLLCSDGLTNKVEGTELKDIL-QS-----DSAPQEKVNLLVDKANQNGGEDNIT-A 233
WP_011247159    166 LRALGTEAQVKVDSFTIPSEFiDTLMICSDGLSNKLAIKELQVEV-ER-----KEELSVIAKSLIARANERGGEDNIS-I 238 Alkalihaloba...
WP_012810687    163 TRSLGTEPVSLPDLTEVPWGEgDVLLLCSDGLSNLVEDDELKVFLeQArgaraKQDVSAAVDAMIQLALDRGGTDNVTaL 242 Alicyclobaci...
WP_015891991    165 MRSLGTEPDVLIDLGQFEWSEgDIVLICSDGLSNKVSHPSLEEKL-QK-----QISLQAKVDGLVQEALDAGGEDNIT-L 237 Brevibacillus
WP_004799854    238 IVLE 241 Amedibacillus dolichus
WP_010530490    238 VIVH 241 Lentibacillus jeotgali
WP_010096722    238 IILQ 241 Ornithinibacillus scapharcae
WP_011065909    238 ILIV 241 Oceanobacillus iheyensis
WP_003181675    239 ALLE 242 Bacillus
WP_013352219    238 VLIE 241 Bacillus amyloliquefaciens
3_ncbifamImport 234 VLLE 237
WP_011247159    239 ALVR 242 Alkalihalobacillus clausii
WP_012810687    243 VAVH 246 Alicyclobacillus acidocaldarius
WP_015891991    238 VAVR 241 Brevibacillus
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