1KL7,1VB3


Conserved Protein Domain Family
Thr-synth_2
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cd01560: Thr-synth_2 
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Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, archaebacteria and eubacterial groups. This CD, Thr-synth_2, includes enzymes from fungi and eubacterial groups, as well as, metazoan threonine synthase-like proteins.
Links
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Statistics
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PSSM-Id: 107203
Aligned: 28 rows
Threshold Bit Score: 509.858
Created: 1-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1KL7_A; catalytic residue (lys) and cofactor (PLP)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1KL7_A      7 VYRSTRsss-------pktISFEEAIIQGLAtDGGLFIPp-tIPQVDQATLFndwskLSFQDLAFAIXRLYiaqeEIPDA 78  baker's yeast
1VB3_A      2 KLYNLKdhn--------eqVSFAQAVTQGLGkNQGLFFPh-dLPEFSLTEIDem-lkLDFVTRSAKILSAFig-dEIPQE 70  Escherichia coli K12
NP_435501   3 KYVSTTggi--------epVGFDEAVLQGFAaDGGLFVPd-rIPVIDQEQLQaf-stLSFQDLAFELVSLYidasIIPRQ 72  Sinorhizobium meli...
NP_662910   2 IFYSTTkas--------apVTMKKATLEGLApDGGLYVPs-tMPHFSAEEIAll-enGSFNNIAFAVAKKFag-dEIPLD 70  Chlorobium tepidum...
NP_696205   4 TFHSTRstn--------dsLTAKQAIRKGIAdDGGLFVSd-aLGKTKVDVASlp--gKSYQQIAAEVLGALl--pDFTAE 70  Bifidobacterium lo...
NP_720550   4 VYQSTRden--------nkVSASLAILQGLArDGGLFTPt-sYPQVDLDFDQlk--tASYQEVAKLVLSAFl--dDFTEA 70  Streptococcus muta...
NP_811314   2 KYYSTNkqa--------pmASLQEAVVKGLAaDRGLFMPm-tIKPLPQEFYDti-dtLSFQEIAYRVADAFfg-eDIPTD 70  Bacteroides thetai...
Q8IYQ7    230 TFISTRhvwpedceqkvsaKFFSEAVIEGLAsDGGLFVPakeFPKLSCGEWKsl-vgATYVERAQILLERCihpaDIPAA 308 human
Q5XH07      2 KYTSTRggl--------igVDFEGVLFSGFApDGGLFMPe-dIPKVDKRTLQtw-ssYSYIQLVKEICSLFispeSIPRA 71  African clawed frog
Q2YDP8      2 RYCSTRagv--------qgRSFRDVLFSGYAaDGGMFMPe-nLPSLSAETLRsw-rrLSYRQLLCEVCELFipeqEIPRE 71  zebrafish

Feature 1                                                   #                                 
1KL7_A     79 DLKDLIKRSYstfr-sdevTPLVQnvtgdkenLHILELFHGPTYAFKDVALQFVGNLFEYFLqrtnanlpegekkQITVV 157 baker's yeast
1VB3_A     71 ILEERVRAAFaf------pAPVANve----sdVGCLELFHGPTLAFKDFGGRFMAQMLTHIAgd----------kPVTIL 130 Escherichia coli K12
NP_435501  73 DLRRLIDNSYrefq-rpdiVNLVPirg--nrdTYVLELFHGPTQSFKDMAMGFLMQVVDYLLgqr--------reRLNIV 141 Sinorhizobium meli...
NP_662910  71 RLSELIDECFtf------dTPLHEld----pdTFVEELFHGPTLAFKDYGARFLARMTGYFAaee--------srLITVL 132 Chlorobium tepidum...
NP_696205  71 ELGQCIADAYgeqwsderiTPLKPlg-----dDYVLELFNGPTSAFKDVALQILPRFMAHTTpadg-----dadeKIMIL 140 Bifidobacterium lo...
NP_720550  71 ELDYCIANAYddkfdtpviAPLVKln-----gQYNLELFHGSTIAFKDMALSILPYLLTTSAkkqg------innKIVIL 139 Streptococcus muta...
NP_811314  71 TLKQIVYDTLsf------dVPLVKva----dnIYSLELFHGPTLAFKDVGGRFMARLLGYFIkke-------gqkDVNVL 133 Bacteroides thetai...
Q8IYQ7    309 RLGEMIETAYgenfacskiAPVRHls----gnQFILELFHGPTGSFKDLSLQLMPHIFAHCIpp---------scNYMIL 375 human
Q5XH07     72 DLEGLIDRAFirfr-hrdiVPITRlk----sgLNVMEMWHGVTHAFKDLAMSCVGELLDYFLkrk--------nkHVTIL 138 African clawed frog
Q2YDP8     72 QLEGLVSSALssfs-vpdaVRLVQlk----dsLSILELFHGETLAFKDLAMSCTAHFLQYFLrrd--------rqRATIL 138 zebrafish

Feature 1                                                                                     
1KL7_A    158 GATSGDTGSAAIYGLRGKk-----dVSVFILYPTGRISPIQEEQXTTVpdeNVQTLSVTGt---FDNCQDIVKAIFGDke 229 baker's yeast
1VB3_A    131 TATSGDTGAAVAHAFYGLp-----nVKVVILYPRGKISPLQEKLFCTLg-gNIETVAIDGd---FDACQALVKQAFDDee 201 Escherichia coli K12
NP_435501 142 LATTGDTGPAAAWAAAGKq-----rIDCWPLYPRGMISREQERQMTTLradNVHPVGVENcpdgGDDLDLVVAELFSDek 216 Sinorhizobium meli...
NP_662910 133 VATSGDTGSAVAYGFHGIp-----nTRVVLLYPSGKVSRLQEQQLTTAg-dNVFALEVKGd---FDDCQRLVKQAFVDqs 203 Chlorobium tepidum...
NP_696205 141 TATSGDTGKAALAGFADAp-----gTAITVFYPEGKVSQVQELQMTTQagsNVQVAAVEGn---FDDAQSAVKRIFGDra 212 Bifidobacterium lo...
NP_720550 140 TATSGDTGKAAMAGFADVp-----gTEIIVFYPNGGVSKIQELQMTTQvgdNTHVVAIEGn---FDDAQTNVKKMFNDsd 211 Streptococcus muta...
NP_811314 134 VATSGDTGSAVANGFLGVe-----gIHVYVLYPKGKVSEIQEKQFTTLg-qNITALEVDGt---FDDCQALVKAAFMDke 204 Bacteroides thetai...
Q8IYQ7    376 VATSGDTGSAVLNGFSRLnkndkqrIAVVAFFPENGVSDFQKAQIIGSqreNGWAVGVESd---FDFCQTAIKRIFNDsd 452 human
Q5XH07    139 VATSGDTGSSAIESVRRRe-----nMDIIVLLPHGRCTKIQELQMTTViedNVHVFSVDGt---SDELDYPIKRLFADsd 210 African clawed frog
Q2YDP8    139 VGTSGDTGSSAIRSVLGLr-----eVDIVVVFPRGRITKIQELQMTTSvaeNVHVFAADGt---SDDIDVPLRKLFADad 210 zebrafish

Feature 1                                                                                     
1KL7_A    230 fn------skhNVGAVnsINWARILAQXTYYFYSFFQAtngk----dskKVKFVVPSGNFGDILAGYFAKKXGLPIEKLA 299 baker's yeast
1VB3_A    202 lk------valGLNSAnsINISRLLAQICYYFEAVAQLpqe-----trnQLVVSVPSGNFGDLTAGLLAKSLGLPVKRFI 270 Escherichia coli K12
NP_435501 217 lk------rtlALSSVnsINWCRVMTQTVHYFYSYYRAver-----vgdPVVFSVPSGAFGNLFAGYLARSMGLPVARFV 285 Sinorhizobium meli...
NP_662910 204 lr------qklTLTSAnsINISRLIPQSFYYAWAALQLrqrk----pdaLPIFSVPSGNYGNLTAGVMAKMMGFPIGHFI 273 Chlorobium tepidum...
NP_696205 213 laerlagnshvVLSSAnsINVGRLVPQVVYYFSAYAQLladqv-invgdEVEFVVPTGNFGDILAGYYAKLLGLPVKHLV 291 Bifidobacterium lo...
NP_720550 212 lrtk-llehgaQFSSAnsMNVGRLVPQVVYYVYAYAQLlksgd-ikngdRVNFTVPTGNFGNILAAYYARQIGVPIGKLI 289 Streptococcus muta...
NP_811314 205 ln------ehlSLTSAnsINVARFLPQAFYYFYAYAQLkrag----kadNAVICVPSGNFGNITAGLFGKKMGLPVKRFI 274 Bacteroides thetai...
Q8IYQ7    453 ftgfltveygtILSSAnsINWGRLLPQVVYHASAYLDLvsqgf-isfgsPVDVCIPTGNFGNILAAVYAKMMGIPIRKFI 531 human
Q5XH07    211 fv------kkhNIMSTnsVNWARILVQIAHFFYGYMQCaplt----eltPVEIIVPTGGAGNITAGCIAQAMGLPIHLVA 280 African clawed frog
Q2YDP8    211 lv------qrhRLMSLnsVNWSRIMVQTAHFLFAYLQLtpslpegdtlpVLEVLVPTGGAGNITAGIIVKRMGVPLRLVA 284 zebrafish

Feature 1                                                                                     
1KL7_A    300 IATNENDILDRFLKsGLYERsd-kVAATLSPAXDILiSSNFERLLWYLAreylangddlkageivnnwfqelktngkfqv 378 baker's yeast
1VB3_A    271 AATNVNDTVPRFLHdGQWSPk--aTQATLSNAMDVSqPNNWPRVEELFRrkiw--------------------------- 321 Escherichia coli K12
NP_435501 286 CANNVNNALHTAFSrGVLPRh--dLVQTPSSAIDIVaPYNFWRLLYFATnrdtarirqwmkdfaar---------revvl 354 Sinorhizobium meli...
NP_662910 274 AASNANDSVTRYLDeGRYEPk--pTVRTLTTAMDVGnPSNFARLRYFFEndfrk-------------------------- 325 Chlorobium tepidum...
NP_696205 292 VASDKNNVLFDFLTtGTYNRqr-pFFQTISPSMDILiSSNLERMLYYLSegdtrlismlmndlnkw---------gtyei 361 Bifidobacterium lo...
NP_720550 290 CASNENNVLTDFFKtGTYDKkr-eFRVTTSPSMDILvSSNLERLIFHLLgndsvktkelmqalie----------kgeyt 358 Streptococcus muta...
NP_811314 275 AANNRNDIFYQYLQtGKYNPr--pSVATIANAMDVGdPSNFARVLDLYGgshad-------------------------- 326 Bacteroides thetai...
Q8IYQ7    532 CASNQNHVLTDFIKtGHYDLrerkLAQTFSPSIDILkSSNLERHLHLMAnkdgqlmtelfnrlesq---------hhfqi 602 human
Q5XH07    281 VVNRNDIVHRTVQY-GDFSLg--dTKATLASAMDIQePYNMERILWLLAgsekshikemmkefqek---------krvkl 348 African clawed frog
Q2YDP8    285 MVNANDIVHRTVQS-GDFSMss-sVTQTLAPAIDIQdPYNMERVFWLLSggdglmvkslmeefqkt---------hklsl 353 zebrafish

Feature 1                                                                                     
1KL7_A    379 dksiiegaskdFTSERVSNEETSETIKKIYessvnpkhYILDPHTAVGVCATERLiakdndksiQYISLSTAHPAKFADA 458 baker's yeast
1VB3_A    322 -------qlkeLGYAAVDDETTQQTMRELKel-----gYTSEPHAAVAYRALRDQlnp----geYGLFLGTAHPAKFKES 385 Escherichia coli K12
NP_435501 355 dvettktiqggFISASISDEETLATVRSVYeae---ghYLIDPHTAVAVAAVEAVrdsl-paaaAIVCFATAHPAKFPDV 430 Sinorhizobium meli...
NP_662910 326 -------mgqeITGIAVSDAETLETIRSVYek----ygYVMDPHTAVGYRALDRFrqdhagagtPGVVLSTAHPVKFDEA 394 Chlorobium tepidum...
NP_696205 362 peellakirqiFGTGWADEDQVRESIKHCWde----hhYVIDPHTACGYYLLEQMprd---pltPRVLLSTASPYKFPRV 434 Bifidobacterium lo...
NP_720550 359 lekadkaildlFAAGFATEEETAAEIKRVYta----srYIEDPHTAVASAVYHAYrkss-gdqsPTVIASTASPYKFPRV 433 Streptococcus muta...
NP_811314 327 -------isaeISGTTYTDEQIRETVKETWke----hhYLLDPHGACGYRALQEGlkq----geTGVFLETAHPAKFLET 391 Bacteroides thetai...
Q8IYQ7    603 ekalveklqqdFVADWCSEGECLAAINSTYnt----sgYILDPHTAVAKVVADRVqdk----tcPVIISSTAHYSKFAPA 674 human
Q5XH07    349 peqlhkkiagaMTSCVVTDENILGTIGRCWee----nhYLLCPHSAVAVYYHYQQmdsn--dksPRCCLAPASAAKFQDV 422 African clawed frog
Q2YDP8    354 paslhqqlsevLSSGSVSDDGILEAMRRCWqd----nhYLICPHTAVAVWRHYQSpvr---pgeSRCCIATASPHKFQQA 426 zebrafish

Feature 1                                                                      
1KL7_A    459 VNNALsgfsnys------------fekdvlpEELKKLst-lKKKLKFIera------dveLVKNA 504 baker's yeast
1VB3_A    386 VEAILgetl-------------------dlpKELAERad-lPLLSHNLpadfa---alrkLMMNH 427 Escherichia coli K12
NP_435501 431 IKRALdveelpa------------aghhpviDEARDAcehlRICQLENlrsn-----ligEMTRQ 478 Sinorhizobium meliloti 1021
NP_662910 395 IKEATgnev-------------------plpETMEEIms-kPKKATLIgnrye---elarFLSEL 436 Chlorobium tepidum TLS
NP_696205 435 VNEALgfdatgtdfecm--dvlahetgttapAALRGLet-aDVRFKDVva--------idGMEDY 488 Bifidobacterium longum NCC2705
NP_720550 434 VVSAVggkdpkddfaav--relsrlsgvsvpRAVDGLet-aEVRHRKVva--------taDMQKA 487 Streptococcus mutans UA159
NP_811314 392 VESIIgeav-------------------eipAKLQEFmk-gEKKSLQMtkefa---dfkkYLLSV 433 Bacteroides thetaiotaomicron VPI-...
Q8IYQ7    675 IMQALkikeinetsssqlyllgsynalpplhEALLER----TKQQEKMeyqvc--aadmnVLKSH 733 human
Q5XH07    423 IIKANltp--------------------dipQEIKDLek-kKTRSHHLtkeddwekvlrqTIESI 466 African clawed frog
Q2YDP8    427 VQRAGltl--------------------elpESLQVLdq-lETRCADLkcsd----dweeTLRRH 466 zebrafish

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