5VGC


Conserved Protein Domain Family
T3SS_NleG

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pfam06416: T3SS_NleG 
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Effector protein NleG
Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system. These effector proteins then alter the host cell's biology in ways that are advantageous to the pathogen. The NleG protein and its homologs form the largest family of effector proteins in the enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone.
Statistics
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PSSM-Id: 368893
Aligned: 13 rows
Threshold Bit Score: 174.08
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5VGC_A                  106 NMDLLSNYQLEE--------------------LLDKIEVCAFNVEHAQLQVPESLRTCPVTLCEPEDGVFMRNSMNSNVC 165
OOO77034                  1 MLQLSSNIGWKKgae---------------naLKNKIHSHSFVVNPDEFSCDTQFLKCPITLCVPEKGVFVKNALNSNIC 65 
BAG66386                 94 LEQRQAAPLVQEsvi---------------ktLLDRINSNAFPVSLQDFSCTEEHLNCPITLHIPETGVFVRNARNSEIC 158
Q8XAN6                   94 MEQSRATPCTRQnvs---------------saIQNKINSHAFTVSHQDFSCHEQHLNCPITLCIPETGVFVRNAKNSEIC 158 Esch...
Q8X508                   97 FQSVMAEHRENKtgn---------------kiLMEKINSCVFGTDSNHFSCPESFLTCPITLDTPXTGVFMRNSRGAEIC 161 Esch...
Q8X507                  105 NMELLSNYQLEE--------------------LLDKIEVCAFNVEHAQLQVPESLRTCPVTLCEPEDGVFMRNSMNSNVC 164 Esch...
AAG56562                 50 MGQVISEFMHSNdnr--------------ielLQRRLHSCSFLVNIEEMSYIDEALQCPITLAIPQRGVFLRNAEGSRVC 115
PRJNA299765:AR439_00145  59 MVSGSGNTQSHGd-------------------IEGKISQCKFSVNTESLQCPSEAVRCPIILDKPEEGVFVKNSEGSLVC 119
Q8X4X1                   81 MLSDSGEAQSQEs-------------------IQNKISQCKFSVCPERLQCPLEAIQCPITLEQPEKGIFVKNSDGSDVC 141 Esch...
PRJNA336330:BFL17_10870  66 MLSDSGEAQSQEs-------------------IQDKISQCKFPVSSGNFQCPPESIQCPITLERPEEGVFVKNSDSSAVC 126
BAF96540                 81 MLSDSGEAQSQEg-------------------IQSKISQYKFSVCPERLQCPPESAQCPITLEIPEEGVFIKNSGDSVVC 141
Q8Z7T2                  106 MSTTSFSNNSQElaahsspgapaifdtsnkqqLVDKIDLCSFSPNVDELSCTEDNLTCPVMLVVPEKGVFVKTGPESNIC 185 Salm...
WP_052895090             87 MEQVRLTPFWLEggr---------------naVQTRINSHAFTVNPGDFPCCEQHLSCPITLCIPKTGVFVKNALHSKVC 151 Esch...
5VGC_A                  166 MLYDKMALIHLVKTRAAHPLSRESIAVSMIVGRDNAAFDPDRGNFVLK 213
OOO77034                 66 TLYDKSAFMNLTREHLPHPLSREKIVKEMIIERNMCYFDTISQHFIIM 113
BAG66386                159 ALYDQEALTELILRNALHPLSRDPFAPEMIISKDKCHFNITKQCFYAL 206
Q8XAN6                  159 SLYDHNALTELIRRNAPHPLSREPFVPEMIVSKDECHFNLIEQYFCIL 206 Escherichia coli O157:H7
Q8X508                  162 SLYDKDALVQLVETGGTHPLSREPITESMIMRKDECHFDAKREAFCCK 209 Escherichia coli O157:H7
Q8X507                  165 MLYDKMSLIYLVKTRAAHPLSRESIAVSMIVGRDNCAFDSDRGNFVLK 212 Escherichia coli O157:H7
AAG56562                116 SLYDEMALSRIINDGMHHPLSREPITLSMLVAREQCEFDCSIGHFTVR 163
PRJNA299765:AR439_00145 120 TLFDSVSFSHLVRDGGKHPLTREPITSSMIVSQEQCIYDQTKGNFVIK 167
Q8X4X1                  142 TLFDAAAFSRLVGEGLPHPLTREPITASIIVKHEECIYDDTRGNFVIK 189 Escherichia coli O157:H7
PRJNA336330:BFL17_10870 127 CLFDFDAFSRLASEGSYHPLTREPITASMIISPDKCVYDPIKGNFIIK 174
BAF96540                142 SLFDVTAFSRLVSEKSPHPLTREKLTASMVVSADKCFYDHGKGSFVIK 189
Q8Z7T2                  186 QLFDETALIQLIIDGATHPVSRAPLSLDMIINKNECYFDTTKGNFIIP 233 Salmonella enterica subsp. enterica ...
WP_052895090            152 SLYDKDALSEAIRHNVFHPLSREAFSPEMIVGREECYFDLTDQRFCII 199 Escherichia coli
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