Conserved Protein Domain Family
lyz_G-like_1
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cd16888: lyz_G-like_1 
lysozyme G-like protein 1
Eukaryotic goose-type or G-type lysozymes (goose egg-white lysozyme; GEWL) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozyme G-like proteins, and this family corresponds to human and mouse lysozyme G-like protein 1. In humans and some other species, the canonical catalytic glutamate residue is absent, suggesting a loss of muramidase activity.
Links
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Statistics
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PSSM-Id: 381609
Aligned: 4 rows
Threshold Bit Score: 317.627
Created: 31-Jul-2019
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative
Feature 1: putative catalytic residue [active site], 1 residue position
Conserved feature residue pattern:EClick to see conserved feature residue pattern help
Evidence:
  • Comment:Glutamate residue involved in cleavage of beta-1,4-glycosidic bond
  • Comment:Lysine present at location of canonical catalytic residue suggests these proteins lack muramidase activity
  • Comment:some members require a second Asp/Glu for activity
  • Citation:PMID 7548026
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                             #                       
Q8N1E2     38 CGIGRRHGL-NYCGVRASERLAEIDMPYLLKYQPMMQTIGQKYCMDPAVIAGVLSRKSPGDKILv---NMGDRTSMVQDP 113 human
ELV11554   38 CMIGRRHGL-NYCGVRASERLAEIDMPYLLRFQPVIRTVGQKYCMDPAVIAGVLSRESPGGNVLv---NVGDGIGAVQDS 113 Chinese tree shrew
ELK38101    2 SVLWLLLGLlALTGVRASERLAEIDMPYLLRYQPMMRTVGQKYCVDPAVIAGVVSRGYPGGNLLvhggNVDDGVRVVQDT 81  Myotis davidii
Q9D7Q0     38 CRIGRRYGL-TYCGVRASERLAEVDRPYLLRHQPTMRLVGQKYCMDPAVIAGVLSRESPGGNYVvdlgNIGSGLGMVKET 116 house mouse

Feature 1                                                                                     
Q8N1E2    114 GSQAPTSWISESQVSQTTEVLTTRIKEIQRRFPTWTPDQYLRGGLCAYSGGAgYVRSSQDLScDFCNDVLARAKYLKRHG 193 human
ELV11554  114 SFYAPTSWITESQVSQKTEVLTSKIKEIQRRFPTWTPDQCLRGGLCAYDGGVgYVKSNQDLScDFCNDVLARAKYLKRHG 193 Chinese tree shrew
ELK38101   82 GHYAPTTWISESQLSQMTEVLTVRIKEIQRRFPTWSPDQCLRGGLCAYVGGPsYVRSSQDLGcDFCNDVLARAKYFKRHG 161 Myotis davidii
Q9D7Q0    117 KFYPPTAWKSETWVSQKTQTLTSSIKEIKTRFPTWTADQHLRGGLCAYSKGPnFVRSNQDLNcDFCNDVLARAKYFKDHG 196 house mouse

Feature 1      
Q8N1E2    194 F 194 human
ELV11554  194 F 194 Chinese tree shrew
ELK38101  162 F 162 Myotis davidii
Q9D7Q0    197 F 197 house mouse

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