2R0B


Conserved Protein Domain Family
DSP_STYX
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cd14522: DSP_STYX 
dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein
Serine/threonine/tyrosine-interacting protein (STYX), also called protein tyrosine phosphatase-like protein, is a catalytically inactive member of the protein tyrosine phosphatase family that plays an integral role in regulating pathways by competing with active phosphatases for binding to MAPKs. It acts as a nuclear anchor for MAPKs, affecting their nucleocytoplasmic shuttling.
Links
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Statistics
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PSSM-Id: 350372
Aligned: 15 rows
Threshold Bit Score: 247.629
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2R0B_A         2 LRREMQEILPGLFLGPYssAMKSKLPVLQKhGITHIICIRQNIEANFIKPnf-qqLFRYLVLDIADnpveNIIRFFPMTK 80  human
XP_975624     32 MRRNMQEIVPGLFLGPYssAQKHCLKTLRDhGISHIICVRQDIEAQYIKPqindlSITYLTLNIADtateNIIRFFPTVR 111 red flour beetle
NP_001019561  26 MRREMQEILPGLFLGPYsaAMKSKLSMLEKqGITHIVCVRQDIEANFIKPnf-phKFRYLVLDIADnpveNIIRYFPTTK 104 zebrafish
EFN89511      37 MRRQMQEVIPGLFLGPYsaASRSKLDSLLEhGITHIVCVRQDIEANFIRPnf-pdKFKYLVLNIADtateNIIQHFQNVK 115 Harpegnathos sa...
XP_001625687  30 KRREMQEIVPGIFLGPYsaAMKSKLEHLKSqGITHIVCIRQNIEANFVKPnf-pnDFLYLVLDVADttteNIIRYFPQVK 108 starlet sea ane...
XP_002613313  27 MRRSMQEILPNVFLGPYsvATKRNLSNLLDlGITHVVCVRDTLEAKIIKPnf-sdHFRYLVLDVADktteNIIQHFPKVK 105 Florida lancelet
XP_002769781  35 MKREAQEILPNLYLGPF--GCARDLDVVRRvGITHIVVVRSVEESRFLREkfvddGIRYLTIDARDspfeNMIRHFKPVS 112 Perkinsus marin...
XP_002117273   5 YRREMQEILPGLYLGPYsaAASSKLEVLLQnGITHILCIRQSLEARFVRPcf-pdRFSYLILEVADtaeeNIIQHFPKVK 83  Trichoplax adha...
XP_007886350  25 MRREMQEILPGLYLGPYsaAMKSKLPILEEnGITHIICVRQDIEANFIKAnf-qeKFRYLVLDIADnpveNIIRYFPVTK 103 elephant shark
XP_002730853  31 MRREMQEITTGLFLGPYaaAMKSKKQALKDmHITHIVCVRQQIEANFIKPnf-sdDFIYLVLDVADkpteNIIKHFVLAK 109 Saccoglossus ko...

2R0B_A        81 EFIDGslq--mggKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCinpnagFVHQLQEYEAIYL 152 human
XP_975624    112 QFIDEafq--rngKVLVHGNNGISRSATLVLAYIMEKYGLSSKEAIECVKQRRGCihpnegFLAQLIEYEPIYK 183 red flour beetle
NP_001019561 105 EFIDGcle--tggKVLVHGNAGISRSAALVIAYLMETFGVKYRDAFSHVQERRFCinpnvgFVHQLQEYEAIYL 176 zebrafish
EFN89511     116 TFIDEgln--sggQVLVHGNAGISRSAALVLAYLMETYGLSQIQAYAIVQQRRFCinpnegFMTQLREYEPIYQ 187 Harpegnathos saltator
XP_001625687 109 AFVDDcvs--kggKVLVHGNAGISRSAALMIAYIMETYGLAYREAFLFVQQRRFCinpnegFTQQLMEYEPIYL 180 starlet sea anemone
XP_002613313 106 EFMDQclq--tggKVLVHGNGGISRSAALVIAYIMETYGMTYRAAFHHVQQRRFCiqpnegFANQLMEYEPIYM 177 Florida lancelet
XP_002769781 113 EFINSvlssspshKILVHGNAGLSRSSTLVAAYIIARYGLSTDETLAYILTRRHCcaphegFKNQLREYEALCR 186 Perkinsus marinus ATC...
XP_002117273  84 AFIDDclq--nngKCLIHDNAGISRSAAFMIAYVMERYNLEFNDAFKLVQKRRFCigpndgFIRQLKVPATNLM 155 Trichoplax adhaerens
XP_007886350 104 EFIDGclq--gggKLLLHGNAGISRSAALVIAYIMETFGLKYRDAFTYVQERRFCinpnagFVHQLQEYEAIYL 175 elephant shark
XP_002730853 110 EFIDNcfn--lggRVLVHGNAGISRSAALVIAYVMETYGLTYRDAFRYVQQRRFCinpnegFVHQLMEYEAIYQ 181 Saccoglossus kowalevskii
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