2X7J,3LQ1,2JLC


Conserved Protein Domain Family
MenD

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COG1165: MenD 
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [Coenzyme transport and metabolism]
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Statistics
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PSSM-Id: 440779
Aligned: 349 rows
Threshold Bit Score: 388.372
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2X7J_A        29 PITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHPDISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAAN 108
WP_013063213   3 SSKQNVNILTSLLVAHGVRYAVVCPGSRNSAIVHNLNECPDIECYPVTDERSAGFYALGIAQVVHRPVAVCVTSGTALLN 82 
WP_013409159   3 SDNKLILQLVSLLKQYEIKRIVISPGSRHYPLIRSLEVDSFFELFSVVDERSAAFFALGLIQNSQEPVAVCCTSGTSTIN 82 
WP_013483600   5 SVEKSIQILIAILKANNIRKVIVSPGTTNISLVVSMVNDGSFEMYSAVDERGAAYIACGLASESGEPVVITCTGSTASRN 84 
WP_015268120   3 SDDRLILQLLSLLKQFNVRKIVVSPGSRHFSIIHSMEKDSFFQLYSVVDERSAAFFALGLIQKSNEPVAVACTSGTSTIN 82 
WP_038562808   3 TNNTQILHLISLLKEYGISKVVISPGSRHYPLTHSLEADKSFQLYSVVDERSAAFFALGLIQESDSPVAICCSSGTASVN 82 
WP_078117963   3 SDDLLVQELLALLKAYNVRHIVIAPGSRHYPITKSLEHDRDFTLYSVVDERSAGFFALGLIQAIGAPVATLCTSGTASIN 82 
WP_108125543   6 TDEKNVLIIISLLKANGISKVIVSPGTTNVAFVASVQQDPFFKLYSAVDERSAAYMACGMAHETGEPVVISCTGATASRN 85 
WP_076931174   3 SEKKNVLQLVALLKAHDITHIVLSPGSRNSPLTHSFATDRDFTCYSVVDERSAGFFTLGIIQAIGKPAAVCCTSGTATLN 82 
WP_071136116   3 SDKKSVLLLLALLKAHGVTSVVLSPGSRNSPLIHSFVADGDFTCYSVVDERSAGFFALGVIMAQRKPVAVCCTSGTAALN 82 
2X7J_A       109 FYPAVVEAHYSRVPIIVLTADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ-KRP 187
WP_013063213  83 VAPAVAEAYYQHMPLVVISADRPAQWIDQLDGQTLPQPDALGRFVKKAVNLPEEYNDE-LHWYCNRLVNEAMNETR-HHG 160
WP_013409159  83 YGSAVVEAFYQKLPLLLLTADRLPEYLGQMEEQMYKQDDTFHHFIKFHGQLKPINNSLD-EWYCNRIINEGLLALS-YRG 160
WP_013483600  85 YYPGLTEAFYRKLPILAITASQDFVRNGNLSPQFIDRTQQPKDSVLLSVQIPIVRNs-ADEYDATIKINRAVTELF-HHG 162
WP_015268120  83 YGSAVVEAFYQHLPLLLLTADRLPELLNQMEEQMFKQDDVFRNFVKFEGQLKEVKSGFD-EWYCNRVINEGLLSLT-SRG 160
WP_038562808  83 YSSAVCEAYYQKLPLLVITIDRLSALLGQTEDQMIKQTNIYENFVNFECTLSMGDNAMD-IWHSNRLINEALIKLT-KKD 160
WP_078117963  83 FGSAVVEAYYQKLPLCVLTPDRLPELLGQMEDQMFPQTTMFQDFTKYVALLKPVLGPLD-KWFVNRVLNEALDALT-TNG 160
WP_108125543  86 YMPGMTEAYYRKLPVLSITSTQATGLVGHNIGQIIDRSKKPNDTQRLSVTLPIVKDEDD-FWDCEVKVNQAILELK-RGG 163
WP_076931174  83 LGPAVAEAFYQQLPLLVITADRPAAWIGQMDGQTIPQSGLFRDLTRRSVQLPQIADEE-EEWYCNRLINEAILSLD-NEV 160
WP_071136116  83 LGPAVAEAYYQQLPLLVITADRPQAWIGQMDGQTIPQAGMYGPLVRRSVQLPEVKDEE-EEWHCNRLINEAILSLGcNGS 161
2X7J_A       188 MGPVHVNVPLREPLMPD--LSDEpfGRmRtgRh---VSVKTGTQSVDRESLS-DVAEML-AEAEKGMIVCGELHS-DA-D 258
WP_013063213 161 CGPVHINVPISEPLFEY--NVEE--L-----PqervIQLLTPRSN-A-ALISlECAGQF-AEAKKPMVVIGQMST-EDlI 227
WP_013409159 161 FGPVHLNFPIESHHSDSf-STSL--L-----PkarkIGI--VGQYSSRHVWN-SIGEKV--NGKKVLIVCGQTFRvPPdF 227
WP_013483600 163 GGPVHINLASS---YTNdfSVEE--LPs---Vh--iINRh------TYSDQK-QYPK-I-ELGKKVGIIIGNHKTfSVqL 223
WP_015268120 161 PGPVHLNIPIESHQGDTf-STAV--L-----PkvrkITR--TRADLEDFQWS-QYAERL--KGKRILVIWGQAAPmSEqL 227
WP_038562808 161 NGPTHINIPIKQHRDLKf-ETKT--L-----PkvrrIFH--HDPELSEQDWK-DSAAML--ENKRIMIVWGQSEPlSNkL 227
WP_078117963 161 GGPVQINIPILNPAEKDf-ATAE--L-----PksrvIRR--HRHVPSPPDWA-AIGQRL--RGKRVQVLWGQSPPpTPaL 227
WP_108125543 164 GGPVHINLPTRYSKNYD--TKk---L-----PtcrvMDRf------T-------VVDEFpEINGKVGIFVGAHRQfTSeE 220
WP_076931174 161 KGPSHINIPLGEPLFGF--NTPT--LP-L--Vr--vIRQSAPGYMI--HKED-RYRERF-GSYSKRMVIVGQLLP-GNgL 226
WP_071136116 162 SAPAHINIPLSEPLFTF--TAEE--LP-K--Ar--vIRQPQPELRLSADQQE-EYLDRF-AGYSRKMVIVGQLPP-GHgL 229
2X7J_A       259 KENIIALSKALQYPILADPLSNLRnGvhdksTVIDAYDSFLKD--DELKRKLRPDVVIRF-GPM-PVSKPVFLWLKDDPT 334
WP_013063213 228 PQELFMLSQ--CAVVVHEALSVGKg--------GTNFDEVIHVlgDNP--AYQPDFVLYL-GDT-LVSKRFKKWLRGLKD 293
WP_013409159 228 ISFFDSFVKQHHAVVLCDHLNNFKlE-----NSFSDTYLIVRSikKIDIKDYCPDIVITLfSNT-VFNGELKSFLKNFPG 301
WP_013483600 224 TEAIDNFCAIYDAVVIVDHSSHYWgN-----YRVLP--TILTCqgAHNSKLFDFELLIHI-GEA-HGDYYTEPYMKR--A 292
WP_015268120 228 RKSLDDFCESYNCAILCDKTSNCRhG-----HAIDNAFVTLRNfsIDEGAKRLPDVVITVfANY-IFNNNIKKYIRRFSP 301
WP_038562808 228 SAALDEFSKTQNYVILTDSISNCThH-----RAILNTFTTLRAlsIPDQDNLAPDFVFTI-GANfVFNLEIKGFLGAYKN 301
WP_078117963 228 QAAFDAFAQAFDVLTLADHLSNLDhA-----SRVRLPLLYLHl-pAARASEMRPDIVITVfGNI-VFQDNVNALFRG-SA 299
WP_108125543 221 IDAIDQFCAANDAVVFCDHTSSFNgK-----YRVGY--ALAASqmKGDMSEDKPDITIHI-GEV-TGDYASIPMVGK--- 288
WP_076931174 227 TEILEKLRKEWDVVVLAEQLSNIPvk------eTSVFDTVLYAasEKELEELTPDLVITL-GGH-IVSKRLKQFIRSARI 298
WP_071136116 230 THVLQHLAEQQHVVVLADRLANLPag------pTARYDALLRTgnREEEQELVPELVITL-GGH-ITSKSLKQFIRKAPL 301
2X7J_A       335 I-QQIVIDEDGGWRDPTQASAHMIHCNASVFAEEIMAGLT-------------------------AAtrSSEWLEKWQFV 388
WP_013063213 294 C-HIWAVTEDGSIHDTSMQLYGVIEGSPADVIEDLVNAIKfk---------------------aiSS--TATFKARWDQA 349
WP_013409159 302 EfEHWHIDQSGKIIDPFQSLTTIFDVSEDVFFEKISSVCG-------------------------TS--NQDYYSKWLQL 354
WP_013483600 293 K-EVWRISEDGEIRDTFGVLTNLFEMTELHFFDTYNKNFQev----------------------nPK--HDQ-----RDL 342
WP_015268120 302 KcEHWSVAPSGDIIDPFHKLTDVFEMDEGFFFRKMAEPSH-------------------------QG--STEYLTSLKAI 354
WP_038562808 302 KlENWQINNGGEISDPFKRLTRVFEMSPTLFFEKITKYSSt-----------------------pGE--SDSYFKQWDVI 356
WP_078117963 300 V-EHWRIGEDGDVSDPFRRLSDVFEMSPEEFFREAAEAVSs-----------------------aSP--QQRY----RQA 349
WP_108125543 289 --EVWRVSPDGELRDTFKKLKYIFEMDEKTFFERYTDKSKa------------------------PS--DGS-----LKR 335
WP_076931174 299 R-EHWHISPSGEVTDTFQRVTDIVRSDNETFLLYLTERLPcleekefsrvrefdetkdfreiknsKE--ARGFRDLWERA 375
WP_071136116 302 R-ELWHLSPSGEVTDTFRRLTDIVRCDPAHFLQRLASMAPq------------------------GA--CTQFLESWKSH 354
2X7J_A       389 NGRFREHLQTISS-EDVSFEGNLYRILQHLVPENS--SLFVGNSMPIRDVDTFFEKqdRPFRIYSNRGANGIDGVVSSAM 465
WP_013063213 350 TRLAAYRAMKF---EPEYSQMAAVKYLEDKLGKAIyrYIHYGNSSPIRFANLY-----AKHYVFCNRGVNGIEGSLSTAA 421
WP_013409159 355 SSSIDE------P-KVGFSELRAIGDFLKVLPNNS--LLHVANSLPIRMLSTFSIA--DNIKVYCNRGVNGIDGCMSTAV 423
WP_013483600 343 FYKEINDIYDQIP-ELPFSNIWIAQQIIPQFPSDA--CLELGVSNTMRSWTFFDFK--SEVYVLANTGCRGIDGAIPTLV 417
WP_015268120 355 SQRIME------P-EVPFSELYAVGQLVKSLPKGA--SLHIANSASARMANLFVTD--ESINAYCNRGVNGIDGCMSAAV 423
WP_038562808 357 AQAVPE------P-EVQYSQLQVLGKLVKKLPENS--VLQIANSNAIRLMHLFKIK--KTVRCYCNRGVNGIDGCMSTAV 425
WP_078117963 350 AMTLVERLPEF-PpDL-YGETAAIGRFLASLSLNC--VLHIANSAPMRMVQFFDID--RSVLVLANRGINGIDGSMSAAV 423
WP_108125543 336 CQKRLEEIRNSVP-NIPFSNVWVASRMAHLIPEGS--VIHFGILNSLRSWNFFDLP--QSVTSTANVGGFGIDGSLSSLI 410
WP_076931174 376 CASVSE------P-DVAFSDLYAAGALMHALPKNS--SLQLGNSNSVRLAQLFDIP--SSVRMFCNRGTNGIEGSLSTAV 444
WP_071136116 355 VARISA------P-EPAYSDLFAAKRFLEQLPVGA--ALHLANSSSVYLAQLFDLP--AGVQLFCNRGTNGIEGSLSTAV 423
2X7J_A       466 GVCEGT-KAPV-TLVIGDLSFYHDLNGLLAAKkLGIPLTVILVNNDGGGIFSFLPQAS--EK------THFEDL------ 529
WP_013063213 422 GCSIVTgDEKV-LCVLGDLSFFYDQNALWNQN-LNGNLHIIVLNNGKGGIFNMLKGLE--QS------PVRDSF------ 485
WP_013409159 424 GYAALS-TEPV-YLIIGDLTFFYDMNALWNRH-LSKNFRILLLNNEGGGVMHMPLPAS--LS------SDLSRY------ 486
WP_013483600 418 GMSLAD-PEKIhFAVMGDLTFFYSFNVLGNRH-IGKNLRILLVNNGCGEEFNIYSNRA--YKiydgdhEKINEFiaagnq 493
WP_015268120 424 GFAAAA-DEPV-YLVIGDLTFFYDMNALWNRH-LSKNLRILLLNNEGGAIMHLPLKES--LA------DVLSKH------ 486
WP_038562808 426 GFAASS-DKIV-YYVTGDLTFFYDMNALWNRY-ISKKLRIVLINNEGGAVMHMPFPKS--QA------RELEQY------ 488
WP_078117963 424 GYAAAS-ERLN-FLVLGDLAFFYDMNSLWIRH-RPENLRILVLNNDGGAIMHSSWGSS----------PQVGKH------ 484
WP_108125543 411 GASLAN-QKKTfFGVIGDLSFFYDMNALGNRH-VGNNLRLMVVNNGKGFEMRRTDGLVghFE------EQADDFicalgh 482
WP_076931174 445 GYASSS-GKLT-FLLIGDLSFFYDMNGLWNNY-STRNLRILLNNNGGGEIFGMLPGLN--KS------EVLHEY------ 507
WP_071136116 424 GYAAVS-EEPT-FLLTGDLSFFYDMNSLWNQH-LSPRLRILLNNNGGGGIFHTLPGLD--RS------ATGDRY------ 486
2X7J_A       530 FGTPTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQA---DK--PGLHLIEIKTDRQSRVQLHRDMLN-EAVRE 597
WP_013063213 486 ISGAHHTTAQGICKQNNIRYMKATNMEEMQQCVDNLLn--KKs-TRPVLLEIFTDADEDERVAKTYYQ-ILKNE 555
WP_013409159 487 VSAGHGTSAEGWVKSLGMDYLAVKNESELARGLQWLVe--NNt-DGSKIVEVFTEKAEDVKILKSYFK-SLDRE 556
WP_013483600 494 TGTRSKQLVKHFAEDIGMKYMTASNKEEFTQLLPEFLn--TEseSDSIIFEVFTDVDEENTALKLIRNiRIDTS 565
WP_015268120 487 ISAGHQTSAKGWVESLGMKYNAVRNQEECDSAVEWLAd--TSq-EGPMVLEVFTKKEVDIKILKKYFG-SLNRE 556
WP_038562808 489 TSAYHNTSAKGWAESVGITYTSVTNEDEAEKAIAEITd--ETm-ETPMLIEVFTKKEEDVEIVKSYYN-SINKV 558
WP_078117963 485 VSAAHHTSVRGWVESLGIRYLSATDFAELDAALVDFTd--DNa-AEAMVLEVFTEKTSDIVQMKAFYE-QISDD 554
WP_108125543 483 FGNKSPTLVKNYAQDLGLKYISASSKEEFDSVYQEFVvkgAS--DESMVFEVFTNGDDESLALDMIRNvSRDSK 554
WP_076931174 508 IAAAHTTEAKAWAEQQGFLYLSAHNAGELEQQLPLFTd--TDs-EKPVLLEVFTSMEKNAEQIRLYYH-KQKRR 577
WP_071136116 487 VAAAHTTEARIWAEQMGFRVLTAHNEEELEQHLPLLMn--SEg-DRPVLLEVFTSMEENSRQIATYYQ-QLKLN 556
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