1B66,1B6Z


Conserved Protein Domain Family
PTPS
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cd00470: PTPS 
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6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is PTPS which catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin. The functional enzyme is a hexamer of identical subunits.
Links
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Statistics
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PSSM-Id: 238264
Aligned: 7 rows
Threshold Bit Score: 185.902
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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pterin bindinghomohexamerputative
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:pterin binding site
Evidence:
  • Comment:there are 6 active sites per hexamer
  • Comment:each monomer contributes to 2 intersubunit catalytic triads composed of Cys, His, and Asp
  • Structure:1B66_A; PTPS binds dihydroneopterin triphosphate and Zn2+
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # #                #     # #                                     ##
1B66_A      6 RARLSRLVSFSASHRLHSpslsaeenlkvfGKCnnpnGHGHNYKVVVTIHGEIDPVTGMVMNLTDLKeYMEEAIMKPLDH 85  black rat
1B6Z_A      6 RARLSRLVSFSASHRLHSpslsaeenlkvfGKCnnpnGHGHNYKVVVTIHGEIDPVTGMVMNLTDLKeYMEEAIMKPLDH 85  Norway rat
1346905     6 VAFLTRRETFSACHRLHSpqlsdaenlevfGKCnnfhGHGHNYTVEITVRGPIDRRTGMVLNITELKeAIETVIMKRLDH 85  fruit fly
2833416     3 STTLFKDFTFEAAHRLPHvp--------egHKCg--rLHGHSFMVRLEITGEVDPHTGWIIDFAELK-AAFKPTYERLDH 71  Escherichia coli
AAK59697   13 IGYITRVQSFSACHRLHSlrlsdeenkevyGKCnnpyGHGHNYKVEVTVRGKIDPVTGMVMNLTDLKkCIEEVIMIPLDH 92  Poecilia reticulata
AAH18029   11 QAQVSRRISFSASHRLYSkflsdeenlklfGKCnnpnGHGHNYKVVVTVHGEIDPATGMVMNLADLKkYMEEAIMQPLDH 90  Homo sapiens
AAK59698   13 IGYITRVQSFSACHRLHSlrlsdeenkevyGKCnnpyGHGHNYKVEVTVRGKIDPVTGMVMNLTDLKkCIEIRTFHQTFL 92  Poecilia reticulata

Feature 1                     ##                                      
1B66_A     86 KNLdldvpyfadvvsTTENVAVYIWENLQRLLPv-gALYKVKVYETDNNIVVYKGE 140 black rat
1B6Z_A     86 KNLdldvpyfadvvsTTENVAVYIWENLQRLLPv-gALYKVKVYETDNNIVVYKGE 140 Norway rat
1346905    86 KNLdkdveyfantpsTTENLAVYIWDNIRLQLKkpeLLYEVKIHETPKNIISYRGP 141 fruit fly
2833416    72 HYLndipg---lenpTSEVLAKWIWDQVKPVVP---LLSAVMVKETCTAGCIYRGE 121 Escherichia coli
AAK59697   93 KNLdkdvpyfadvvsTTENLAVYIWDNMAKALPa-sLPYEIRIHETDKNIVVYRGE 147 Poecilia reticulata
AAH18029   91 KNLdmdvpyfadvvsTTENVAVYMWDNLQKVLPv-gVLYKVKVYETDNNIVVYKGE 145 Homo sapiens
AAK59698   93 LSLt----------sTTENLAVYIWDNMAKALPa-sLPYEIRIHETDKNIVVYRGE 137 Poecilia reticulata

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