3KYJ,2LP4,1WN0,4EUK,2R25


Conserved Protein Domain Family
Hpt
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pfam01627: Hpt (this model, PSSM-Id:396273 is obsolete and has been replaced by 426352)
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Hpt domain
The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).
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Statistics
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PSSM-Id: 396273
Aligned: 229 rows
Threshold Bit Score: 29.627
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KYJ_A   11 EIWALYADDGAQALDAMEASLlalqagedAAA--HVGPLFRAVHTFKGNSRVLGLSVVESRAHLCEDLIglvRDAGVPMD 88   Rhodobacter sphaero...
Q8EBQ2  824 DMLRMLLDSLPQTVSAIEAAL--------SQN--DQVTMLSTIHKLHGASCYCGVPTTQRLCQEIESALk--REARVEDL 891  Shewanella oneidensis
Q9KPC0  835 EMLGMLVDYLREVETVVNTAL--------EDEeyPASDLLHHIHKLHGSCSYSGVPRLRKICASLEQALr--NGASIDEL 904  Vibrio cholerae
Q87LP4  839 DMLRMLIDFIPEVEEVVDHAL--------EQDdySREELIHVIHKLHGSSSYCGVPRLKSLCATLEHALr--SGASIEEI 908  Vibrio parahaemolyt...
Q83AW7  571 KMFKLFLEELPRFHEDIKKAF--------EAN--DRKALAFHVHKLNGAACYAPTPRLQKILVDFESKL---RSRSPIDL 637  Coxiella burnetii
Q83EH1   23 ELLALFASELPALRDGINAAF--------DKA--DWKEMKNQVHKLHGSCCYTGTPHLKHLSQELEEAL---KLRNHGAV 89   Coxiella burnetii
Q847W1 1133 EIARVFSQSMAMDIENLQAAP-------------TERDKKRVIHGIKGAVGAIGISMLTELCIEAER-------VTAAEF 1192 Vibrio parahaemolyt...
Q89IW6   51 GLAGEFKDWMTTEVNRLSAAYvairhdgfTKD--RRDELFRAAHDIKGDAATFGYPAAAGVAESLCRVIe----HAPDLE 124  Bradyrhizobium japo...
Q7UZ66  903 AIVSDFIVRLDQRLVDMRNEL--------RDQ--RFDALELSAHWLKGAGGTVGYGDLTQPSRDLID-------AALAAN 965  Pirellula sp.
Q8D1G7  830 ALSLKLYQSLQVLIQQAKDAI----------E--NLPVLSHTLHTIKGCAGQAGLIELQDAVIQLEHALd---tHETLTQ 894  Yersinia pestis

3KYJ_A   89 GEIVEillfasdTLRAMLEETAAS 112  Rhodobacter sphaeroides
Q8EBQ2  892 EPEIL-------ELLDELTKVESA 908  Shewanella oneidensis
Q9KPC0  905 EPELF-------ELQDEMAKVLEA 921  Vibrio cholerae
Q87LP4  909 EPEMF-------ELQDEMIKVTTT 925  Vibrio parahaemolyticus
Q83AW7  638 KPYYD-------KLEKELQAVLAT 654  Coxiella burnetii
Q83EH1   90 PLFLE-------RLNSEIQRVLNA 106  Coxiella burnetii
Q847W1 1193 DRRAAel---ilRIEQEIDNIDYW 1213 Vibrio parahaemolyticus
Q89IW6  125 RVPAE-------LFTHHINAILAI 141  Bradyrhizobium japonicum
Q7UZ66  966 PADCE-------TYLSQIESVRAR 982  Pirellula sp.
Q8D1G7  895 QEIIQ------------LDEIIHV 906  Yersinia pestis
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