Conserved Protein Domain Family
Imidazolone-5PH
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cd01296: Imidazolone-5PH 
Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria, the enzyme is part of histidine utilization (hut) operon.
Links
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Statistics
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PSSM-Id: 238621
Aligned: 21 rows
Threshold Bit Score: 454.024
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       # #                             
NP_715737    31 IAVKDGKIAWLGprselpa------fdvlsipVYRGKGgWITPGLIDAHTHLVFAGNRANEFELRLKGATYeei-araGG 103 Shewanella oneid...
ZP_00019639  48 VAIRGSTIIAVGssnelrr-------rfrpaqEIDAGGhAVCPGLIDCHTHIVYAGDRVAEFEQRCAGATYqei-maaGG 119 Chloroflexus aur...
NP_627290    34 VVVEGDRVVWTGesska----------patdnRVDADGrAVLPGFVDSHSHLLFAGDRTEEFNARMSGRPYs------AG 97  Streptomyces coe...
Q9HQD6       33 VAVVDGAVAAVGdtadvlaa----ypaenattAIDATGkTVLPGFVDPHTHALFAGDRSDEFAAKLRGKPYqei-laeGG 107 Halobacterium sp...
ZP_00058273  51 IVMRDGIIAWVGpaaslpqsipgvidhiadaqIDNAGGaLVTPGLIDAHAHPVYAGNRYAEISARSEGASQsdi-vaaGG 129 Thermobifida fusca
AAQ94395     41 VGERKDYLARLQrrtsvq---------papfaTWSAGGrLITPGLVECHTHLIFSGDRRTEFAELASGRNYsdl-vweGH 110 Hyphomicrobium c...
NP_604298    31 LLIENERIKKIGtyedlkke-----issnnfqEIDCSDkVVMPGYVDCHTHLIFGESRVDEYVASFTMTKNeiknkivRT 105 Fusobacterium nu...
Q9RZ05       36 LLVRGGVIQWVGpraaa----------ptathVHDLGGrAVVPGLVDPHTHAVWAGDRLSDWEAKLQGATYeei-larGG 104 Deinococcus radi...
Q983I1       36 IATRDGLIIYAGaeasmpa------lagpgaeTVDCEGrWITPGLIDCHTHLVYAGNRANEFEMRLAGATYeev-araGG 108 Mesorhizobium loti
Q8XW31       33 IAVRDGRIAWLGaradlpa-------garaerEHDGGGaWLTPGLIDCHTHLVHAGNRSNEFEARLNGVPYehi-araGG 104 Ralstonia solana...

Feature 1                                                                                       
NP_715737   104 GIISTVNACREADEAALFELGRQRLNALAKEGVTTVEIKSGYGLDTETELKILRVARElgkh-hhvDVKTTFLgAHAVPP 182 Shewanella oneid...
ZP_00019639 120 GILRTMQLTRAATTTTLVAETLPRLNQMLRFGTTTAEVKTGYGLEQDAELRQLATIELlaav-qpiELVPTFLpAHAIPP 198 Chloroflexus aur...
NP_627290    98 GIRTTVAATRAASDAELEAGLTRYLAEALRQGTTTFETKSGYGLTTADESRALRVAARh-------TDEVTFLgAHIVAP 170 Streptomyces coe...
Q9HQD6      108 GILRTVDAVRAASDAALVANLTAQLDVMLAHGTTTAEVKTGYGLDTETECRMLDAIAAaaae-hpvDVVTTFLgAHAVPD 186 Halobacterium sp...
ZP_00058273 130 GVSSTVTVTRGTDPWTLCNDVRDRLRHWLLWGTTTVEAKTGYHLTRDGELADVRLLRSleeepgmpRLHVTFFaAHAIPP 209 Thermobifida fusca
AAQ94395    111 GIFATVEATRAASEDELYSSALRRLRWFVSGGVTTIETKSGYGLDVDNELKMLRVARRldea-glaRVKATLLaGHVYPS 189 Hyphomicrobium c...
NP_604298   106 GIEASIFSTRNATDEELINSSLIKLNRMLKHGTTTVEIKSGYGIDMETEIRLLKLINIlkek-spqTILSTYLgAHYFDT 184 Fusobacterium nu...
Q9RZ05      105 GIRSTMRATAAADVAELVALARPRLASLRASGATTTEVKSGYGLDFDAELRMLRAVRElqa---efELRPTLL-IHVPPQ 180 Deinococcus radi...
Q983I1      109 GIVSSVKSLRAANEDELVAQTLPRLDALMAEGVTTVEVKSGYGLDLDNEKKSLRAARRlane-rpvTIRTTCLaAHALPP 187 Mesorhizobium loti
Q8XW31      105 GILSTVRATRAASEDALAQASLPRLNALRAEGVTTVEIKSGYGLDLETERRMLRVARRfgqt-lrvRVRTTFLgAHAVPP 183 Ralstonia solana...

Feature 1                                                                             #  #      
NP_715737   183 eykgnsdgyvDLIINKMLPavik---------enlADAVDVFCENIAFn-lEQTERVLSAAKaaGLQVKLHAEQLSNMGG 252 Shewanella oneid...
ZP_00019639 199 efadrpdayiDLVVESMLPlaqeryrnslfaghhiPLFVDVFCERGAFd-vAQSRRVLSAARerGLPRKAHVDEFTELGG 277 Chloroflexus aur...
NP_627290   171 eladdpaayvDLVTGEMLDaca-----------phARWIDVFCEKGAFd-gDQARAILTAGKarGLHPRIHANQLSYGPG 238 Streptomyces coe...
Q9HQD6      187 dtda--dayvDAVIDDQLPaaa----------ngpARFCDVFCEADVFt-vEQSRRILDAGRehGLAPKLHAEEFTRLGG 253 Halobacterium sp...
ZP_00058273 210 eyfgr-hrdyVQAVGSWLGdaa----------qagADGVDVYCDNRQFt-tEDARWILTLGRaaGLKTRIHACSKPRHGA 277 Thermobifida fusca
AAQ94395    190 qiep--edfiELICSELIPqaha---------gklCDFVEAYCEETIGfslDDASTLLEAAYkrKIPTRISADHLSDSAG 258 Hyphomicrobium c...
NP_604298   185 kmgk--ekyiDFMINEVMPvikk---------enlAQFCDVWCDEGYYn-aEDCYKILKAGLenDMLPTLHTECYSAIGG 252 Fusobacterium nu...
Q9RZ05      181 egra---eyvVGVCAELIPqvar---------eglAEALDVFCEKEAFs-vEETRTMFAAAQahGLRVKLHADQFHAIGG 247 Deinococcus radi...
Q983I1      188 eakgdkeafvDLVAGTILPgvaa---------eklADAVDGFCEGIAFs-pEQIARVFDKARalGLPVKLHADQLSNLHG 257 Mesorhizobium loti
Q8XW31      184 efagraddyiGHLCADVLPalaa---------eglVDAVDAFCETIGFs-pAQTARMFDAAQalGLPVKLHAEQLSDQGG 253 Ralstonia solana...

Feature 1                    #                                                        #         
NP_715737   253 SELAARLGAKSVDHIEYLDEAGVKALsESGTCAVLLPGAFYFLRetqkPPIDLLRQy-----GVPMVLASDFNPGSFPIc 327 Shewanella oneid...
ZP_00019639 278 LAMALEMEATSVDHLDVTGAAAFPALaASNTIAVLLPLVSINLGithfAAARQMIDa-----GVAIALSTDANPGSAPSl 352 Chloroflexus aur...
NP_627290   239 VRLAVELDAASADHCTHLTDADVDALaNSRTVATLLPGAEFSTRaq-wPDARRLIDa-----GATVALSTDCNPGSSFTs 312 Streptomyces coe...
Q9HQD6      254 AQLAADLGATSADHLLHATPEDAAALaDAGVTPVLLPATAFVLDea-yADPQQFLAaadnrtGAPVALGTDLNPNCYTHs 332 Halobacterium sp...
ZP_00058273 278 VRMAAEMQCNSVDLLHETDEEDLVALaRTKTPVVVCPTASLNECr--tPPVRALLDh-----GVPVALGTDHNPAHCGTt 350 Thermobifida fusca
AAQ94395    259 AALAPAFYAKAAAHLNYTDDVAIEALaSARTTAILLPIAHLELGakqrPPVDKLREa-----GVPIAISTGCNPGTAPTt 333 Hyphomicrobium c...
NP_604298   253 AKVAAELKAANVGHLNYISSEDIKLLkEANVVGVLIPSTDFSVKhkkpFVPKPMLDe-----GMTIAIATNLNPGNWVEd 327 Fusobacterium nu...
Q9RZ05      248 TELACEVGALSVDHLEASGAAQIAALaASETVATILPGVTLHLGlp-aAPGRQLIDs-----GAIVAIGTDLNPGSSPLf 321 Deinococcus radi...
Q983I1      258 AALAASYGALSADHLEYTDEAGAAAMaKAGTVATILPGAYYFIRetkkPPVDLFRRh-----GVKMAVATDSNPGTSPLt 332 Mesorhizobium loti
Q8XW31      254 AALVARYGGLSADHLECLTDAGVAAMaEAGTVAVLLPGAFYCLRetrlPPLQALRQa-----GVPMAVSTDCNPGTSPLs 328 Ralstonia solana...

Feature 1                                                                                    
NP_715737   328 sTLLMLNMGCTLFRLTPEEALAGLTLNAAKALGied-kvGSLVVGKQADFCLWNIatpaqLAYSYGVnpckdVVKNG 403 Shewanella oneidens...
ZP_00019639 353 sLPLTMAIACRYLRMVPAEALLATTVNAAHAIGlgg-riGALMPGMQADLIILAEadyrwLMYELGGtpiaqVIKRG 428 Chloroflexus aurant...
NP_627290   313 sVPFCIALAVRDMGMTPDEAVWSATAGGAAALRre--dvGRLVPGAYADLTLLDApshvhLAYRPGVplvagVWRRG 387 Streptomyces coelic...
Q9HQD6      333 -MGFVVSLACNGMRMAPADAVLAATAWAASALDrgrdgtGTLREGTDGDVLVVDApshvhLPYNPGVnnveaVLTDG 408 Halobacterium sp. N...
ZP_00058273 351 mMSLVVCMAIGLYGLSVQEALRAATVGGAQALGtl--drGVIAVGKVADVVQWDAehegaFAWSYGLka-mrVWRGG 424 Thermobifida fusca
AAQ94395    334 nLLTAAHLSCALFGLSPLEAIQGITVGAAKALGlsg-vvGELTPGANADFAIWDAehpedLIYWMGAplccsTWLSG 409 Hyphomicrobium chlo...
NP_604298   328 -MNISMILACRNHKMTENEAIRATTLGGAKALKiek-dyGSLEVSKFADIQIRNSdsyknVVYKFGVneiehVIKNG 402 Fusobacterium nucle...
Q9RZ05      322 sTQLALALAVRLCLLTPAEALSACTVNAAYALGls--drGSLSAGQRADFLVLNGqdwreVAYTLGGnavaeVYLAG 396 Deinococcus radiodu...
Q983I1      333 sLLLTMNMAATLFGLTVDECLAGVTREAARALGlld-ktGTLEAGKSADLAIWDIerpaeLVYRMGFnplhaRIWRG 408 Mesorhizobium loti
Q8XW31      329 sLLLAMNMACTLFRLTPLEALTGATRHAAAALGlag-tcGVLAPGCVADFALWRIdrpadLAYAMGLnpcagVVKDG 404 Ralstonia solanacearum

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