Conserved Protein Domain Family
glyox_I
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TIGR00068: glyox_I 
lactoylglutathione lyase
Lactoylglutathione lyase is also known as aldoketomutase and glyoxalase I. Glyoxylase I is a homodimer in many species. In some eukaryotes, including yeasts and plants, the orthologous protein carries a tandem duplication, is twice as long, and hits this model twice. [Central intermediary metabolism, Amino sugars, Energy metabolism, Other]
Links
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Statistics
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PSSM-Id: 272886
Aligned: 10 rows
Threshold Bit Score: 234.7
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q42891     1 MaseskdspsnnpglhatpdeatkgyFLQQTMFRIKDPKVSLEFYSKVLGMSLLKRLDFPEMKFSLYFMGYEDTASApsd 80  tomato
P44638     1 M-------------------------QILHTMLRVGDLDRSIKFYQDVLGMRLLRTSENPEYKYTLAFLGYEDGESA--- 52  Haemophilus influen...
Q59384     1 M-------------------------RLLHTMLRVGDLQRSIDFYTKVLGMKLLRTSENPEYKYSLAFVGYGPETEE--- 52  Escherichia coli
AAA21576   1 ---------------------------ILHTMLRVGDLDKSIKFYTEVMGMQLLRTNENKEYEYTLAFVGYGDESQG--- 50  Vibrio parahaemolyt...
Q55595     1 M-------------------------FLLHTMIRVGDLDKSLQFYCDILGMNLLRKKDYPSGEFTLAFVGYGKESEN--- 52  Synechocystis sp. P...
O33393     1 M-------------------------RLLHTMLRVGNLEKSLDFYQNVLGMKLLRRKDYPEGRFTLAFVGYGDETDS--- 52  Neisseria meningiti...
AAB95240  63 Vaesgkaaqattq-ddlltwvkndkrRMLHVVYRVGDMDRTIKFYTECLGMKLLRKRDIPEEKYTNAFLGYGPEDSH--- 138 thale cress
Q39366     1 Maenadlve----------wpkkdkrRFLHVVYRVGDLDRTIQFYTECFGMKVLRKRDVPEEKYSNAFLGFGPETSN--- 67  Brussels sprouts
O04885     1 MaseakespannpglstvrdeatkgyIMQQTMFRVKDPKASLDFYSRVLGMSLLKRLDFSEMKFSLYFLGYEDTSTAptd 80  Brassica juncea
AAD38008   5 qppsggltdeaalsccsdadpstkdfLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIpke 84  human

Q42891    81 pvertawtfsqkSTLELTHNWGTESdpnftgYHNGNseprGFGHIGVTVDDVYKACERFESLGVEFVKKP--LDGKMKGI 158 tomato
P44638    53 ------------AEIELTYNWGVDK------YEHGT----AYGHIAIGVDDIYATCEAVRASGGNVTREAgpVKGGSTVI 110 Haemophilus influen...
Q59384    53 ------------AVIELTYNWGVDK------YELGT----AYGHIALSVDNAAEACEKIRQNGGNVTREAgpVKGGTTVI 110 Escherichia coli
AAA21576  51 ------------AVIELTYNWGKTE------YDLGT----AFGHIAIGVDDIYATCDAIKAAGGNVTREAgpVKGGTTHI 108 Vibrio parahaemolyt...
Q55595    53 ------------AVIELTHNWGTDK------YDLGN----GFGHIALGVEDIYSTCDKIRDKGGKVVREPgpMKHGTTVI 110 Synechocystis sp. P...
O33393    53 ------------TVLELTHNWDTER------YDLGN----AYGHIAVEVDDAYEACERVKRQGGNVVREAgpMKHGTTVI 110 Neisseria meningiti...
AAB95240 139 ------------FVIELTYNYGVDK------YDIGA----GFGHFGIAVDDVAKTVELVKAKGGKVSREPgpVKGGKTVI 196 thale cress
Q39366    68 ------------FVVELTYNYGVSS------YDIGT----GFGHFAISTQDVSKMVEAVRAKGGNVTREPgpVKGGGSVI 125 Brussels sprouts
O04885    81 ptertvwtfgrpATIELTHNWGTESdpefkgYHNGNseprGFGHIGVTVDDVHKACERFEQLGVEFVKKP--HDGKMKNI 158 Brassica juncea
AAD38008  85 kdekiawalsrkATLELTHNWGTEDdat-qsYHNGNsdprGFGHIGIAVPDVYSACKRFEELGVKFVKKP--DDGKMKGL 161 human

Q42891   159 AFIKDPDGYWIEIFDTKIIKDAAGS 183 tomato
P44638   111 AFVEDPDGYKIEFIENKSTKSGLGN 135 Haemophilus influenzae Rd KW20
Q59384   111 AFVEDPDGYKIELIEEKDAGRGLGN 135 Escherichia coli
AAA21576 109 AFVKDPDGYMIELIQNKQASAGLEG 133 Vibrio parahaemolyticus
Q55595   111 AFVEDPDGYKIELIQTSSKKD---- 131 Synechocystis sp. PCC 6803 substr. Kazusa
O33393   111 AFVEDPDGYKIEFIQKKSGDDSVAY 135 Neisseria meningitidis serogroup A
AAB95240 197 AFIEDPDGYKFELLERGPTPEPLCQ 221 thale cress
Q39366   126 AFVKDPDGYTFELIQRGPTPEPLCQ 150 Brussels sprouts
O04885   159 AFIKDPDGYWIEIFDLKTIGTTAGN 183 Brassica juncea
AAD38008 162 AFIQDPDGYWIEILNPNKMATLM-- 184 human
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